Approaches targeting K(V)10.1 open a novel window for cancer diagnosis and therapy.

Abstract:

:K(V)10.1 has recently become generally accepted as a promising cancer target, as it is ectopically expressed in the majority of solid tumors. Due to its cell-surface accessibility, K(V)10.1 has a strong potential for tumor treatment and diagnosis. Given that its mode of action is likely independent of conventional cancer pathways such as tyrosine kinases, K(V)10.1 opens a novel window for treating cancer. In this review we will give an overview of the current status of data linking K(V)10.1 to cancer, and propose techniques that could exploit K(V)10.1's properties for the management of cancer.

journal_name

Curr Med Chem

authors

Pardo LA,Gómez-Varela D,Major F,Sansuk K,Leurs R,Downie BR,Tietze LF,Stühmer W

doi

10.2174/092986712798992011

subject

Has Abstract

pub_date

2012-01-01 00:00:00

pages

675-82

issue

5

eissn

0929-8673

issn

1875-533X

pii

BSP/CMC/E-Pub/2012/055

journal_volume

19

pub_type

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