Abstract:
:Ten years elapsed since the discovery by Sanofi of SR141716A the first selective CB(1) cannabinoid receptor antagonist. Shortly after, Sanofi also reported the synthesis of the first selective CB(2) cannabinoid receptor antagonist, SR144528. Since these two milestones in the cannabinoid field, many other compounds, more or less related to the Sanofi compounds, or based on a completely different scaffold appeared. Several of these compounds are currently involved in clinical trials for diseases such as obesity, nicotine and alcohol addictions, or allergies. Further, the cannabinoid receptors knock-out mice production strengthened the hypothesis of the existence of several other "cannabinoid" receptors for which the first antagonists begin to appear. The large amount of patents taken by many different pharmaceutical companies prove, if necessary, the great therapeutic potential expected for the cannabinoid receptors antagonists.
journal_name
Curr Med Chemjournal_title
Current medicinal chemistryauthors
Muccioli GG,Lambert DMdoi
10.2174/0929867054020891subject
Has Abstractpub_date
2005-01-01 00:00:00pages
1361-94issue
12eissn
0929-8673issn
1875-533Xjournal_volume
12pub_type
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