Abstract:
:Multitarget-directed ligands (MTDLs), an emerging and appealing drug discovery strategy, utilizing a single chemical entity to inhibit multitargets, was confirmed to be effective in reducing the likelihood of drug resistance, diminishing problems of dosing complexity, drug-drug interactions and toxicities, as well as improving patient compliance. The exploration of MTDL strategy should be valuable in anti-HIV drug discovery. In this article, current knowledge and strategies for the rational design of the multitarget and selective anti-HIV agents are described and a number of illustrative examples are given. Moreover, the challenges, limitations and outlook of such novel drug design strategies are also presented, with a goal to highlight the representative paradigms in the rational design of MTDLs, and to help medicinal chemists discover the next generation of multitarget anti-HIV agents.
journal_name
Curr Med Chemjournal_title
Current medicinal chemistryauthors
Zhan P,Liu Xdoi
10.2174/0929867311320130011subject
Has Abstractpub_date
2013-01-01 00:00:00pages
1743-58issue
13eissn
0929-8673issn
1875-533Xpii
CMC-EPUB-20130214-10journal_volume
20pub_type
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