Targeting Ceramide Metabolism in Hepatocellular Carcinoma: New Points for Therapeutic Intervention.

abstract：:Onychomycosis (fungal nail infections) is very common worldwide but is fortunately not often lethal. Several powerful drugs have been introduced into clinical practice in recent years, but these infections remain difficult to cure primarily due to the difficulty of penetration of drug to the site of the infection in t...

journal_title：Current medicinal chemistry

authors： Basha A,Basha F,Ali SK,Hanson PR,Oakley BR,Hajovsky H,Mitscher LA

更新日期：2016-05-27 00:00:00

abstract：:To this point, efforts to develop therapeutic peptides for intracellular applications were guided by the perception that unmodified linear peptides are highly unstable and therefore structural modifications are required to reduce proteolytic breakdown. Largely, this concept is a consequence of the fact that most resea...

journal_title：Current medicinal chemistry

authors： Zuconelli CR,Brock R,Adjobo-Hermans MJW

更新日期：2017-01-01 00:00:00

abstract：:Diabetes mellitus (DM) is characterized by hyperglycemia, resulting from defects in insulin secretion, insulin action or both. There are several factors such as hyperlipidemia and oxidative stress (OS), namely the production of reactive oxygen/nitrogen species (ROS/RNS), that actively contribute to the development and...

journal_title：Current medicinal chemistry

authors： Sousa A,Ribeiro D,Fernandes E,Freitas M

更新日期：2020-05-24 00:00:00

abstract：BACKGROUND:The evolutionarily conserved Hedgehog (Hh) signaling cascade is one of the key mediators of embryonic development of many metazoans. This pathway has been extensively targeted by small molecule inhibitors as its misregulation leads to various malignancies and developmental disorders. Thus, blocking this path...

journal_title：Current medicinal chemistry

authors： Khatra H,Bose C,Sinha S

更新日期：2017-01-01 00:00:00

abstract：:Protein p53 is a key player in mitochondrial mediated apoptotic cell death and excess p53 activity has been implicated in many disease states such athrosclerosis, diabetes, osteoarthritis, Alzheimer's disease, Parkinson's disease, Huntington's disease, AIDS, P. falciparum and S. typhimurium infections. Thus, chemical ...

journal_title：Current medicinal chemistry

authors： Nayak SK,Panesar PS,Kumar H

更新日期：2009-01-01 00:00:00

abstract：:Vitamin D has been known for a long time as a major factor involved in the calcium- phosphate balance and homeostasis, along with parathyroid hormone (PTH). While vitamin D effects on calcium and phosphate are fully known, recent studies attempted to link vitamin D status and cardiovascular diseases. The involvement o...

journal_title：Current medicinal chemistry

authors： Santoro D,Pellicanò V,Cernaro V,Lacava V,Lacquaniti A,Atteritano M,Buemi M

更新日期：2016-01-01 00:00:00

abstract：:Aberrant activation of the signal transducer and activator of transcription (STAT) 3 occurs in many human tumors. Constitutive STAT3 activity induces specific target genes that stimulate cell proliferation, prevent apoptosis, promote angiogenesis and facilitate tumor immune evasion. Thus, STAT3 is an attractive molecu...

journal_title：Current medicinal chemistry

authors： Zhao M,Jiang B,Gao FH

更新日期：2011-01-01 00:00:00

abstract：:The cation-independent mannose 6-phosphate receptor is a multifunctional protein which binds at the cell surface to two distinct classes of ligands, the mannose 6-phosphate (M6P) bearing proteins and IGF-II. Its major function is to bind and transport M6P-enzymes to lysosomes, but it can also modulate the activity of ...

journal_title：Current medicinal chemistry

authors： Gary-Bobo M,Nirdé P,Jeanjean A,Morère A,Garcia M

更新日期：2007-01-01 00:00:00

abstract：:Mast cells are best known as central effector cells in IgE-mediated type I allergic diseases including asthma and hay fever. An increasing amount of evidence, however, has demonstrated that mast cells are sentinel cells playing a critical role in host defense against invading microbes. Mast cells are located immediate...

journal_title：Current medicinal chemistry

authors： Matsuguchi T

更新日期：2012-01-01 00:00:00

abstract：:Drug-loaded nanoparticles have shown great potential in the study of carriers for disease-targeting drug delivery. Drug-loaded nanoparticles are excellent in keeping the drug in the systemic circulation for a prolonged period of time, introducing targeting molecules to improve targeting efficiency and to reduce side e...

journal_title：Current medicinal chemistry

authors： Tu Q,Zhang Y,Liu R,Wang JC,Li L,Nie N,Liu A,Wang L,Liu W,Ren L,Wang X,Wang J

更新日期：2012-01-01 00:00:00

abstract：:First described by Alois Alzheimer in 1907, Alzheimer's disease (AD) is the most common dementia type, affecting approximately 20 million people worldwide. As the population is getting older, AD is a growing health problem. AD is currently treated by symptomatic drugs, the acetylcholinesterase inhibitors, based on the...

journal_title：Current medicinal chemistry

authors： Francotte P,Graindorge E,Boverie S,de Tullio P,Pirotte B

更新日期：2004-07-01 00:00:00

abstract：:Inflammation is an initial response of the body to a harmful stimuli and it is achieved by the increased movement of leukocytes (especially granulocytes) from blood into injured tissues. It is required for healing wounds and infections. Despite their indispensable role in microbial killing, the inflammation reactions ...

journal_title：Current medicinal chemistry

authors： Soubhye J,Aldib I,Delporte C,Prévost M,Dufrasne F,Antwerpen PV

更新日期：2016-01-01 00:00:00

abstract：:Many serious inflammatory disorders and nutrient deficiencies induce chronic pain, and anti-inflammatory diets have been applied successfully to modify the inflammatory symptoms causing chronic pain. Numerous scientific data and clinical investigations have demonstrated that long-term inflammation could lead to an ina...

journal_title：Current medicinal chemistry

authors： Bjørklund G,Chirumbolo S,Dadar M,Pen JJ,Doşa MD,Pivina L,Semenova Y,Aaseth J

更新日期：2020-01-01 00:00:00

abstract：:Cardiotrophin-1 (CT-1), a member of the interleukin (IL)-6 family, is reported to exhibit a plethora of pleiotropic effects in the heart such as cytoprotective, pro-proliferative and pro-fibrotic ones. An extensive research has been devoted on proliferative and profibrotic effects of CT-1 on the heart. Thus the presen...

journal_title：Current medicinal chemistry

authors： García-Cenador MB,Lopez-Novoa JM,Díez J,García-Criado FJ

更新日期：2013-01-01 00:00:00

abstract：:The immunophilin ligands cyclosporin A, FK506 and rapamycin are best known for their immunosuppressive properties and their clinical use in transplantation medicine. These compounds or their analogs are also clinically used or investigated in various types of cancer, coronary angioplasty, dermatology, hepatitis C infe...

journal_title：Current medicinal chemistry

authors： Gaali S,Gopalakrishnan R,Wang Y,Kozany C,Hausch F

更新日期：2011-01-01 00:00:00

abstract：:This investigation aims to evaluate strategies for an efficient selection of bioactive compounds from the multitude and biodiversity of the plant kingdom. Statistics prove natural products (NPs) as a source leading most consistently to successful development of new drugs. However, there are several reasons why the int...

journal_title：Current medicinal chemistry

authors： Rollinger JM,Langer T,Stuppner H

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:Patients with diabetes mellitus have an increased risk of mortality due to cardiovascular complications. Supplementation with specific sulphur-containing amino acids is rapidly emerging as a possible therapeutic adjuvant for diabetes and associated cardiovascular complications. OBSERVATIONS:It is well-known...

journal_title：Current medicinal chemistry

authors： Tappia PS,Adameova A,Dhalla NS

更新日期：2018-01-30 00:00:00

abstract：:Cell-based electrochemical biosensors have contributed tremendously to the fields of biology, medicine, chemistry, pharmacology, and environmental science. With electrochemical transducers and whole cells as the recognition elements, these biosensors provide new horizons for biosensing and life science research. This ...

journal_title：Current medicinal chemistry

authors： Ding L,Du D,Zhang X,Ju H

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:The possibilities of treatment for oncological diseases are growing enormously in the last decades. Unfortunately, these developments have led to the onset of resistances with regards to the new treatments. This is particularly true if we face with the therapeutic field of Tyrosine Kinase Inhibitors (TKIs). ...

journal_title：Current medicinal chemistry

authors： Zanforlin E,Zagotto G,Ribaudo G

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Since the serendipitous discovery of the antitumor activity of cisplatin there has been a continuous surge in studies aimed at the development of new cytotoxic metal complexes. While the majority of these complexes have been designed to interact with nuclear DNA, other targets for anticancer metallodrugs att...

journal_title：Current medicinal chemistry

authors： Erxleben A

更新日期：2019-01-01 00:00:00

abstract：:Histone deacetylase inhibitors have generated significant interest as anti-cancer agents due to their ability to cause growth arrest, terminal differentiation and/ or apoptosis in carcinoma cells. Abbott entered this area after the serendipitous discovery of the biaryl hydroxamate A-161906 in a TGF beta mimetic screen...

journal_title：Current medicinal chemistry

authors： Curtin M,Glaser K

更新日期：2003-11-01 00:00:00

abstract：:Angiogenesis is known to be essential for the development and progression of cancer. Vascular endothelial growth factor (VEGF) is a critical mediator in tumor angiogenesis for many solid malignancies, including breast cancer. Increased levels of VEGF have been associated with poor clinical outcomes, including reduced ...

journal_title：Current medicinal chemistry

authors： Bareschino MA,Schettino C,Colantuoni G,Rossi E,Rossi A,Maione P,Ciardiello F,Gridelli C

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:Lipids are essential components of cells that participate in metabolic and endocrine regulation and reproductive functions. The main organs where lipid regulation takes place are the liver and adipose tissue. Besides, when each tissue specific action cannot be exerted, it could lead to several endocrine-meta...

journal_title：Current medicinal chemistry

authors： Ferrer MJ,Silva AF,Abruzzese GA,Velázquez ME,Motta AB

更新日期：2021-01-06 00:00:00

abstract：:Poly(aminoester) dendrimers are expected to hold great promise as biodegradable nanocarriers for drug delivery due to their advantageous properties allowing their biodegradability, potentially lower toxicity and possibility of diverse chemical conjugations. The synthetic strategies for constructing such dendrimers inc...

journal_title：Current medicinal chemistry

authors： Wang Y,Quelever G,Peng L

更新日期：2012-01-01 00:00:00

abstract：: ...

journal_title：Current medicinal chemistry

authors： Stepnowski P,Paszkiewicz M

更新日期：2019-01-01 00:00:00

abstract：:Epidemiological studies demonstrated that even in the absence of other risk factors (e.g. diabetes, hypertension, hyperhomocysteinemia, hypercholesterolemia), advanced age itself significantly increases cardiovascular morbidity by enhancing vascular oxidative stress and inflammation. Because the population in the West...

journal_title：Current medicinal chemistry

authors： Labinskyy N,Csiszar A,Veress G,Stef G,Pacher P,Oroszi G,Wu J,Ungvari Z

更新日期：2006-01-01 00:00:00

abstract：:Alzheimer's disease (AD) is a widespread form of dementia that is estimated to affect 44.4 million people worldwide. AD pathology is closely related to the accumulation of amyloid beta (Aβ) peptides in fibrils and plagues, the small oligomeric intermediate species formed during the Aβ peptides aggregation presenting t...

journal_title：Current medicinal chemistry

authors： Chiorcea-Paquim AM,Enache TA,Oliveira-Brett AM

更新日期：2018-01-01 00:00:00

abstract：:Peptide-based nanoparticles (pep-NPs) are emerging as promising imaging and therapeutic agents against cancer due to their biocompatibility and tunability. Optimized design of the peptide sequence and moderate conjugation of the sequence with extraneous molecules are crucial to the performance of the inherent properti...

journal_title：Current medicinal chemistry

authors： An L,Shah Gilani MR,Liang G

更新日期：2014-01-01 00:00:00

abstract：OBJECTIVE:We found a novel marine drug, SZ-685C, that was isolated from the secondary metabolites of a mangrove endophytic fungus (No. 1403) collected from the South China Sea, which has been reported to inhibit the proliferation of certain tumor cells. However, its anticancer mechanism remains unknown. The aims of thi...

journal_title：Current medicinal chemistry

authors： Chen CH,Xiao WW,Jiang XB,Wang JW,Mao ZG,Lei N,Fan X,Song BB,Liao CX,Wang HJ,She ZG,Zhu YH

更新日期：2013-01-01 00:00:00

abstract：:Leukemia is a life threatening disease that has become increasingly common. Many categories of anti-leukemic agents have been developed by probing into the nature of leukemia. Nevertheless, the needs for potent molecules with few side effects are still not satisfied in the current anti-leukemic therapy. Targeted thera...

journal_title：Current medicinal chemistry

authors： Bian J,Zhang L,Han Y,Wang C,Zhang L

更新日期：2015-01-01 00:00:00