Abstract:
:First described by Alois Alzheimer in 1907, Alzheimer's disease (AD) is the most common dementia type, affecting approximately 20 million people worldwide. As the population is getting older, AD is a growing health problem. AD is currently treated by symptomatic drugs, the acetylcholinesterase inhibitors, based on the cholinergic hypothesis (1976). During the past decade, advances in neurobiology have conducted to the identification of new targets. Although some of these innovative approaches tend to delay onset of AD, others are still symptomatic. In this review, we present an overview of the several strategies and new classes of compounds against AD.
journal_name
Curr Med Chemjournal_title
Current medicinal chemistryauthors
Francotte P,Graindorge E,Boverie S,de Tullio P,Pirotte Bdoi
10.2174/0929867043364946subject
Has Abstractpub_date
2004-07-01 00:00:00pages
1757-78issue
13eissn
0929-8673issn
1875-533Xjournal_volume
11pub_type
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更新日期:2015-01-01 00:00:00
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更新日期:2013-01-01 00:00:00
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