Abstract:
:The present paper summarizes the possible roles of frequent and unfavourable genetic variants in cerebrovascular disorders, such as stroke and leukoaraiosis. It also approaches the topic theoretically from functional and mathematical points of view, which can help make the accumulating data on genetic variants more understandable. The interplay of an unfavourable genetic polymorphism and environmental clinical factors can result in a cerebrovascular disease or a state of vascular dementia. These constantly changing functional interactions need a highly specialised approach. There is, therefore, a great need to summarise the results on genetic polymorphisms concisely, and to discuss their special but shared features, which make their evaluation difficult with the methods used for the well-known Mendelian factors. The development of a correct approach to genetic polymorphisms may have a great impact on the understanding and prevention of cerebrovascular diseases.
journal_name
Curr Med Chemjournal_title
Current medicinal chemistryauthors
Szolnoki Zdoi
10.2174/092986709788803006subject
Has Abstractpub_date
2009-01-01 00:00:00pages
3168-73issue
24eissn
0929-8673issn
1875-533Xjournal_volume
16pub_type
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