Abstract:
:The immunophilin ligands cyclosporin A, FK506 and rapamycin are best known for their immunosuppressive properties and their clinical use in transplantation medicine. These compounds or their analogs are also clinically used or investigated in various types of cancer, coronary angioplasty, dermatology, hepatitis C infections, and neuroprotection. Furthermore, the role of immunophilins in various pathologies is increasingly being recognized, supporting the preclinical drug development for novel immunophilin targets. Finally, immunophilin ligands are widely used as sophisticated tools in chemical biology. This review shows the progress on three major areas made in the last five years. An update of the immunosuppressive ligands and their clinical applications is discussed in the first part of the review, followed by a discussion about the emerging immunophilin targets and their respective ligands. The final section gives a detailed assessment of immunophilin ligand-based tools.
journal_name
Curr Med Chemjournal_title
Current medicinal chemistryauthors
Gaali S,Gopalakrishnan R,Wang Y,Kozany C,Hausch Fdoi
10.2174/092986711798194342subject
Has Abstractpub_date
2011-01-01 00:00:00pages
5355-79issue
35eissn
0929-8673issn
1875-533Xpii
BSP/CMC/E-Pub/2011/396journal_volume
18pub_type
杂志文章,评审abstract::The evidence seems to be growing in favor of the stem cell theory of cancer with the emergence of studies demonstrating the parallel mechanisms of self renewing pathways in stem cells and particular subsets of cancer cells. The finding of leukemia stem cells and subsequently breast cancer stem cells (BCSC) further sup...
journal_title:Current medicinal chemistry
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