Abstract:
:Hydroxypyridinones (HPs) are a family of N-heterocyclic metal chelators, which have been an attractive target in the development of a variety of new pharmaceutical drugs, due to their high metal chelating efficacy/specificity and easy derivatization to tune the desired biological properties. In fact, along the last decades, hydroxypyridinone derivatives, but mostly 3-hydroxy-4-pyridinone (3,4-HP), have been intensively used in drug design, following either a multitarget approach, in which one chelating unity is extrafunctionalized (hybridized) to enable the interaction with other important specific biological sites, or a polydenticity approach, in which more than one chelating moiety is conveniently attached to one scaffold, to increase the metal chelating efficacy. This review represents an update of the most recent publications (2014-2016) in mono-HP hybrids, namely as potential anti-Alzheimer's drugs, inhibitors of metalloenzymes and anti-microbials, and also polychelating compounds (poly- HP), in view of potential application, such as anti-microbial/biostatic agents, luminescent biosensors or diagnostic agents.
journal_name
Curr Med Chemjournal_title
Current medicinal chemistryauthors
Chaves S,Piemontese L,Hiremathad A,Santos MAdoi
10.2174/0929867324666170330092304subject
Has Abstractpub_date
2018-01-01 00:00:00pages
97-112issue
1eissn
0929-8673issn
1875-533Xpii
CMC-EPUB-82563journal_volume
25pub_type
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