Abstract:
:O-Prenyl secondary metabolites (3,3-dimethylallyl, geranyl-, farnesyl- and related biosynthetic derivatives) represent a class of rarely occurring natural products. In the last two decades such compounds have been found to exert promising and effective pharmacological activities, mainly in terms of anti-cancer properties. To date about 350 oxyprenylated secondary metabolites, the most part of which having a phenylpropanoid or a polyketide core, have been extracted from plants mainly belonging to the Rutaceae, Apiaceae, and Fabaceae families, and from fungi and bacteria. The aim of this comprehensive review is to make a survey of the in so far reported literature citations about O-prenyl secondary metabolites exhibiting in vitro and in vivo anti-cancer properties from phytochemical and pharmacological point of views.
journal_name
Curr Med Chemjournal_title
Current medicinal chemistryauthors
Genovese S,Fiorito S,Epifano F,Taddeo VAdoi
10.2174/0929867322666150716114758subject
Has Abstractpub_date
2015-01-01 00:00:00pages
3426-33issue
30eissn
0929-8673issn
1875-533Xpii
CMC-EPUB-68893journal_volume
22pub_type
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