Abstract:
:Numerous compounds with a benzothiazole scaffold that have been described in the literature show promising activities against several Gram-positive and Gramnegative bacteria, and also against Mycobacterium tuberculosis. Benzothiazole-based antibacterial compounds bind to different biological targets in bacterial cells and have been shown to be inhibitors of enzymes that are important for essential processes in the bacterial cells, such as cell-wall synthesis, cell division, and DNA replication, or are important for different biosynthetic pathways of essential compounds in bacterial cells, such as the biosynthesis of histidine and biotin. This review focuses on the antibacterial potential of benzothiazole-based compounds, in terms of their specific interactions with targets in bacterial cells. We assess the importance of the benzothiazole scaffold in the discovery of new antibacterial compounds, the potential of benzothiazole-based compounds against resistant bacterial strains, optimization of their antibacterial activity, and the future perspectives of benzothiazole-based antibacterials.
journal_name
Curr Med Chemjournal_title
Current medicinal chemistryauthors
Gjorgjieva M,Tomašič T,Kikelj D,Mašič LPdoi
10.2174/0929867324666171009103327subject
Has Abstractpub_date
2018-01-01 00:00:00pages
5218-5236issue
38eissn
0929-8673issn
1875-533Xpii
CMC-EPUB-86257journal_volume
25pub_type
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