Abstract:
:In the last decade, drug resistant invasive mycoses have become significantly more common and new antifungal drugs and ways to specifically deliver them to the fungal cell are being looked for. One of the biggest obstacles in finding such comes from the fact that fungi share essential metabolic pathways with humans. One significant difference in the metabolism of those two cells that can be challenged when looking for possible selective therapeutics is the uptake of zinc, a nutrient crucial for the fungal survival and virulence. This work summarizes the recent advances in the biological inorganic chemistry of zinc metabolism in fungi. The regulation of zinc uptake, various types of its transmembrane transport, storage and the maintenance of intracellular zinc homeostasis is discussed in detail, with a special focus on the concept of a constant 'tug of war' over zinc between the fungus and its host, with the host trying to withhold essential Zn(II), and the fungus counteracting by producing high-affinity zinc binding molecules.
journal_name
Curr Med Chemjournal_title
Current medicinal chemistryauthors
Walencik PK,Watly J,Rowinska-Zyrek Mdoi
10.2174/0929867323666160817163834subject
Has Abstractpub_date
2016-01-01 00:00:00pages
3717-3729issue
32eissn
0929-8673issn
1875-533Xpii
CMC-EPUB-77850journal_volume
23pub_type
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