p53-Induced apoptosis and inhibitors of p53.

Abstract:

:Protein p53 is a key player in mitochondrial mediated apoptotic cell death and excess p53 activity has been implicated in many disease states such athrosclerosis, diabetes, osteoarthritis, Alzheimer's disease, Parkinson's disease, Huntington's disease, AIDS, P. falciparum and S. typhimurium infections. Thus, chemical inhibitors of p53 activation might prove effective in suppressing diseases associated with excess p53 activity. Diverse chemical compounds are being synthesized and evaluated as potent inhibitors of p53 in many cell types. In this review, we have focused on the effects of apoptosis, which is involved in p53 protein and inhibition of p53 induced apoptosis. Peculiar features of p53 protein and its roles in various diseases are summarized along with important inhibitors developed in recent years.

journal_name

Curr Med Chem

authors

Nayak SK,Panesar PS,Kumar H

doi

10.2174/092986709788681976

subject

Has Abstract

pub_date

2009-01-01 00:00:00

pages

2627-40

issue

21

eissn

0929-8673

issn

1875-533X

journal_volume

16

pub_type

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