SRC family kinases as potential therapeutic targets for malignancies and immunological disorders.

abstract：BACKGROUND:Neuronal α4β2 nAChRs are receptors involved in the role of neurotransmitters regulation and release, and this ionic channel participates in biological process of memory, learning and attention. This work aims to review the structure and functioning of the α4β2 nAChR emphasizing its role in the treatment of a...

journal_title：Current medicinal chemistry

authors： Laikowski MM,Reisdorfer F,Moura S

更新日期：2019-01-01 00:00:00

abstract：:The use of dopaminergic agonists is key in the treatment of Parkinson's disease and related central nervous system (CNS) neurodegenerative disorders. Despite there are a number of commercialized dopaminergic agonists that are currently being used successfully in the first stages of the disease, they often fail to prov...

journal_title：Current medicinal chemistry

authors： Matute MS,Matute R,Merino P

更新日期：2016-01-01 00:00:00

abstract：:A BRAF somatic mutation at residue 600 of the BRAF protein (BRAFV600E) is highly prevalent in papillary thyroid carcinomas (PTC). This mutation occurs in approximately 44% (from 29% to 83%) of PTC depending on the different studies. BRAFV600E is almost always found in PTC with a papillary or a mixed follicular/papilla...

journal_title：Current medicinal chemistry

authors： Lassalle S,Hofman V,Ilie M,Butori C,Bozec A,Santini J,Vielh P,Hofman P

更新日期：2010-01-01 00:00:00

abstract：:Cellular resistance to anthracyclines is a major limitation of their clinical use in the treatment of human tumors. Resistance to doxorubicin is described as a multifactorial phenomenon involving the overexpression of defense factors and alterations in drug-target interactions. Such changes do not account for all mani...

journal_title：Current medicinal chemistry

authors： Perego P,Corna E,De Cesare M,Gatti L,Polizzi D,Pratesi G,Supino R,Zunino F

更新日期：2001-01-01 00:00:00

abstract：:The new drug class of dipeptidyl peptidase-4 (DPP4) inhibitors has been widely accepted in the daily management of type 2 diabetes since its strategic advantages with regard to body weight, risk of hypoglycaemia, and beta cell survival. We have previously evaluated the theoretical implications of DPP4 inhibition given...

journal_title：Current medicinal chemistry

authors： Matteucci E,Giampietro O

更新日期：2011-01-01 00:00:00

abstract：:Polymyxins are polypeptide antibiotics, with a primary effect of membrane damaging due to their selective binding to the lipopolysaccharide of Gram-negative bacteria. Their nephro- and neurotoxic side effects limited their use, however, in the last decade the emergence of multidrug-resistant Gram-negative bacteria led...

journal_title：Current medicinal chemistry

authors： Kadar B,Kocsis B,Nagy K,Szabo D

更新日期：2013-01-01 00:00:00

abstract：:The design and development of radiolabelled steroid derivatives has been an important area of research due to their wellknown value in breast cancer targeting. The estrogen receptor (ER) and progesterone receptor (PR) are important biomarkers in the diagnosis, prognosis and follow-up of the therapeutic response of bre...

journal_title：Current medicinal chemistry

authors： Oliveira MC,Neto C,Ribeiro Morais G,Thiemann T

更新日期：2013-01-01 00:00:00

abstract：:Enteroviruses are members of picornavirus family which causes diverse and severe diseases in humans and animals. Clinical manifestations of enterovirus infections include fever, hand, foot, and mouth disease, and herpangina. Enteroviruses also cause potentially severe and life-threatening infections such as meningitis...

journal_title：Current medicinal chemistry

authors： Li C,Wang H,Shih SR,Chen TC,Li ML

更新日期：2007-01-01 00:00:00

abstract：:The calcium ion is quite possibly the single most pervasive signaling molecule used by living organisms for the purpose of communicating internal and external states. It differs from other messengers in that it is neither created nor destroyed, but just moved around inside and outside the cell via transporters, pumps ...

journal_title：Current medicinal chemistry

authors： Hofer AM

更新日期：2012-01-01 00:00:00

abstract：:Tuberculosis (TB) is the leading cause of mortality due to a single infectious agent. The currently used combination drug regimens produce cure rates that exceed 95%, given good patient adherence during the multiple months treatment period. However the recent surge in HIV infections and the synergy between HIV and TB ...

journal_title：Current medicinal chemistry

authors： Budha NR,Lee RE,Meibohm B

更新日期：2008-01-01 00:00:00

abstract：:The lung is a unique organ in terms of its direct exposure to high levels of oxygen and reactive compounds. Several parenchymal lung diseases (e.g. emphysema associated with smoking and a number of fibrotic lung disorders) have been proposed to be due to the exposure of the lung to exogenous irritants leading to local...

journal_title：Current medicinal chemistry

authors： Kinnula VL,Vuorinen K,Ilumets H,Rytilä P,Myllärniemi M

更新日期：2007-01-01 00:00:00

abstract：:Cardiotrophin-1 (CT-1), a member of the interleukin (IL)-6 family, is reported to exhibit a plethora of pleiotropic effects in the heart such as cytoprotective, pro-proliferative and pro-fibrotic ones. An extensive research has been devoted on proliferative and profibrotic effects of CT-1 on the heart. Thus the presen...

journal_title：Current medicinal chemistry

authors： García-Cenador MB,Lopez-Novoa JM,Díez J,García-Criado FJ

更新日期：2013-01-01 00:00:00

abstract：:Kit is a growth factor receptor of the type III tyrosine kinase family, whose gain-of-function mutations have been identified as driving causes of different kinds of tumours. It thus represents a viable drug target, and the development of Kit inhibitors has been shown to be a promising therapeutic concept. This review...

journal_title：Current medicinal chemistry

authors： Sartini S,Dario B,Morelli M,Da Settimo F,La Motta C

更新日期：2011-01-01 00:00:00

abstract：: ...

journal_title：Current medicinal chemistry

authors： Poplawski T

更新日期：2019-01-01 00:00:00

abstract：:Reprogramming technologies have been developed to revert somatic differentiated cells into pluripotent stem cells that can be differentiated into different lineages potentially useful in stem cell therapy. Reprogramming methods have been progressively refined to increase their efficiency, to obtain a cell population s...

journal_title：Current medicinal chemistry

authors： Tafani M,Perrone GA,Pucci B,Russo A,Bizzarri M,Mechanick JI,Carpi A,Russo MA

更新日期：2014-01-01 00:00:00

abstract：:It is now widely accepted that airway inflammation is the key factor underlying the pathogenesis of asthma. Inhaled corticosteroids remain the most important anti-inflammatory treatment for asthma. However, they are rather non-specific in their actions and their use raises concerns over side effects and compliance iss...

journal_title：Current medicinal chemistry

authors： Walsh GM

更新日期：2006-01-01 00:00:00

abstract：:N-BP, rapamycin and its derivatives have been originally developed respectively as anti-resorptive and anti-fungal agents. In fact, in vitro and in vivo experiments demonstrated that these compounds are multi-functional molecules exerting their effects on tumour cell growth and bone remodelling. The major challenge in...

journal_title：Current medicinal chemistry

authors： Ory B,Moriceau G,Redini F,Heymann D

更新日期：2007-01-01 00:00:00

abstract：:Xanthones (dibenzo-γ-pyrones) constitutes an important class of oxygenated heterocycles and occur as secondary metabolites in plants and microorganisms. They are known for various biological activities such as antioxidant, monoamine oxidase inhibitor, antihypertensive, hepatoprotective, antithrombotic, antifungal and ...

journal_title：Current medicinal chemistry

authors： Panda SS,Chand M,Sakhuja R,Jain SC

更新日期：2013-01-01 00:00:00

abstract：:The therapeutical use of drugs involves the application of dosage forms, serving as carrier systems together with several excipients to deliver the active ingredient to the site of action. Drug delivery technology combines an understanding of medicinal chemistry and pharmacology with the skill of formulation, aiming t...

journal_title：Current medicinal chemistry

authors： Kalász H,Antal I

更新日期：2006-01-01 00:00:00

abstract：:Cardiovascular pathologies in the French are not prevalent despite high dietary saturated fat consumption. This is commonly referred to as the "French Paradox" attributing its anti-lipidemic effects to moderate consumption of red wine. Resveratrol, a phytoalexin found in red wine, is currently the focus of intense res...

journal_title：Current medicinal chemistry

authors： Raval AP,Lin HW,Dave KR,Defazio RA,Della Morte D,Kim EJ,Perez-Pinzon MA

更新日期：2008-01-01 00:00:00

abstract：:Melatonin, a tryptophan-derived neurohormone found in animals, plants, and microbes, participates in various biological and physiological functions. Among other properties, numerous in vitro or in vivo studies have reported its therapeutic potential against many parasites, bacteria and viruses. In this concern, melato...

journal_title：Current medicinal chemistry

authors： Elmahallawy EK,Luque JO,Aloweidi AS,Gutiérrez-Fernández J,Sampedro-Martínez A,Rodriguez-Granger J,Kaki A,Agil A

更新日期：2015-01-01 00:00:00

abstract：:From the discovery of Endothelial Progenitor Cells (EPC), these bone marrowderived precursors have been placed as crucial mediators of the endothelial repair. Accordingly, altered levels and function of EPC have been found in different scenarios of CV risk. Despite the fact that EPC exhibit important characteristics w...

journal_title：Current medicinal chemistry

authors： Rodríguez-Carrio J,López P,Suárez A

更新日期：2018-01-01 00:00:00

abstract：:ATP-sensitive K(+) channels (K(ATP)channels) regulate insulin secretion by coupling intracellular metabolic changes to excitability of the plasma membrane in pancreatic beta-cells. The channels are closed when extracellular glucose levels are elevated due to enhanced feature. By contrast, cardiac-type K(ATP) channels,...

journal_title：Current medicinal chemistry

authors： Kakei M

更新日期：2003-02-01 00:00:00

abstract：:High-resolution nuclear magnetic resonance (NMR) spectroscopy is a universal analytical tool. It can provide detailed information on chemical shifts, J coupling constants, multiplet patterns, and relative peak areas. It plays an important role in the fields of chemistry, biology, medicine, and pharmacy. A highly homog...

journal_title：Current medicinal chemistry

authors： Lin Y,Zeng Q,Lin L,Chen Z

更新日期：2019-01-01 00:00:00

abstract：:Many of the currently available treatments for obsessive-compulsive and related disorders (OCRDs) such as pharmacotherapy augmentation strategies, partial hospitalization programs, deep brain stimulation, and neurosurgery are efficacious for individuals suffering from more severe forms of these conditions. Unfortunate...

journal_title：Current medicinal chemistry

authors： Fontenelle LF,Zeni-Graiff M,Quintas JN,Yücel M

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:A great effort has been made to develop efficacious antiviral drugs, but many viral infections are still lack of efficient antiviral therapies so far. The related exploration of natural products to fight viruses has been raised in recent years. Natural compounds with structural diversity and complexity offer...

journal_title：Current medicinal chemistry

authors： Wu YH,Zhang BY,Qiu LP,Guan RF,Ye ZH,Yu XP

更新日期：2017-01-01 00:00:00

abstract：:Matrix metalloproteinase-9 (MMP-9) plays an important role in the onset and prognosis of myocardial infarction. Targets of angiotensin converting enzyme (ACE) inhibitors might include not only ACE but also MMP-9, and ACE seems to be closely associated with complications of hypertension such as cardiovascular remodelin...

journal_title：Current medicinal chemistry

authors： Yamamoto D,Takai S

更新日期：2009-01-01 00:00:00

abstract：:The use of antisense oligonucleotides as therapeutic agents has generated considerable enthusiasm in the research and medical community. Antisense oligonucleotides as therapeutic agents were proposed as far back as in the 1970s when the antisense strategy was initially developed. Nonetheless, it has taken almost a qua...

journal_title：Current medicinal chemistry

authors： Aboul-Fadl T

更新日期：2005-01-01 00:00:00

abstract：:β-Aryl-β-amino acids constitute very useful scaffolds able to lead, via various intra-molecular cyclisation reactions, to a great diversity of cyclic derivatives with numerous biological and therapeutic properties. The present article aims at reporting an exhaustive overview of these ring-closure sequences and their a...

journal_title：Current medicinal chemistry

authors： Rochais C,Rault S,Dallemagne P

更新日期：2010-01-01 00:00:00

abstract：:Angiogenesis is known to be essential for the development and progression of cancer. Vascular endothelial growth factor (VEGF) is a critical mediator in tumor angiogenesis for many solid malignancies, including breast cancer. Increased levels of VEGF have been associated with poor clinical outcomes, including reduced ...

journal_title：Current medicinal chemistry

authors： Bareschino MA,Schettino C,Colantuoni G,Rossi E,Rossi A,Maione P,Ciardiello F,Gridelli C

更新日期：2011-01-01 00:00:00