Abstract:
:Enteroviruses are members of picornavirus family which causes diverse and severe diseases in humans and animals. Clinical manifestations of enterovirus infections include fever, hand, foot, and mouth disease, and herpangina. Enteroviruses also cause potentially severe and life-threatening infections such as meningitis, encephalitis, myocarditis, polio-like syndrome, and neonatal sepsis. With the emergence of enterovirus all over the world as the major causative agent of HFMD fatalities in recent years and in the absence of any effective anti-enteroviral therapy, there is clearly a need to find a specific antiviral therapy. Steps such as viral attachment, uncoating, viral RNA replication, and protein synthesis in the replication cycle can serve as potential targets for antiviral agents. Agents targeted at viral protein 1 (VP1), a relatively conserved capsid structure mediating viral adsorption and uncoating process, is of great potential to be anti-enterovirus drugs. Recently, considerable efforts have been made in the development of antiviral compounds targeting the capsid protein of enterovirus. This review summarizes the development of small molecules targeting enteroviral capsid protein as effective antiviral therapy.
journal_name
Curr Med Chemjournal_title
Current medicinal chemistryauthors
Li C,Wang H,Shih SR,Chen TC,Li MLdoi
10.2174/092986707780363032subject
Has Abstractpub_date
2007-01-01 00:00:00pages
847-56issue
8eissn
0929-8673issn
1875-533Xjournal_volume
14pub_type
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更新日期:2020-09-17 00:00:00
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更新日期:2016-01-01 00:00:00
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