Ozone: A Multifaceted Molecule with Unexpected Therapeutic Activity.

abstract：:Among the strategies that can lead to the discovery of new drugs, the identification and use of privileged structures, molecular fragments that are able to interact with more than one target, gained particular attention, in an attempt to find new drugs in a shorter time with respect to other strategies. These structur...

journal_title：Current medicinal chemistry

authors： Costantino L,Barlocco D

更新日期：2006-01-01 00:00:00

abstract：:Antimicrobial resistance is an ever-increasing problem throughout the world and has already reached severe proportions. Two very common neglected tropical diseases are Chagas' disease and leishmaniasis. Chagas' disease is a severe health problem, mainly in Latin America, causing approximately 50000 deaths a year and m...

journal_title：Current medicinal chemistry

authors： Bandyopadhyay D,Samano S,Villalobos-Rocha JC,Sanchez-Torres LE,Nogueda-Torres B,Rivera G,Banik BK

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:Numerous studies have reported sex and gender differences in the prevalence and treatment of cardiovascular diseases. However, sex differences in the therapy of hypertension have not been completely examined. OBJECTIVE:To estimate the gender-specific dissimilarity in outcomes among patients following antihy...

journal_title：Current medicinal chemistry

authors： Giorgini P,Sahebkar A,Stamerra CA,Raparelli V,Petrarca M,Grassi D,Ferri C,Di Giosia P

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:Despite the historical employment of boron-containing compounds (BCCs) with medicinal purposes, the reported cases of BCC toxicity in humans during the twentieth century were driving us towards an "boron-withdrawal" period. Fortunately, the use of boric acid for specific purposes remains, and the discovery o...

journal_title：Current medicinal chemistry

authors： Soriano-Ursúa MA,Farfán-García ED,Geninatti-Crich S

更新日期：2019-03-27 00:00:00

abstract：:Many of the currently available treatments for obsessive-compulsive and related disorders (OCRDs) such as pharmacotherapy augmentation strategies, partial hospitalization programs, deep brain stimulation, and neurosurgery are efficacious for individuals suffering from more severe forms of these conditions. Unfortunate...

journal_title：Current medicinal chemistry

authors： Fontenelle LF,Zeni-Graiff M,Quintas JN,Yücel M

更新日期：2018-01-01 00:00:00

abstract：:Apoptotic cell death has been reported in human oocytes and preimplantation embryos under in vivo and in vitro conditions. BCL-2 family proteins comprise both anti- and pro-apoptotic members, which are likely to play a key role in controlling oocyte and early embryo survival. However, very limited data are available o...

journal_title：Current medicinal chemistry

authors： Boumela I,Assou S,Haouzi D,Déchaud H,Aït-Ahmed O,Hamamah S

更新日期：2014-01-01 00:00:00

abstract：:Matrix metalloproteinases (MMPs) are a large family of calcium-dependent zinc- containing endopeptidases, which are responsible for the tissue remodeling and degradation of the extracellular matrix (ECM), including collagens, elastins, gelatin, matrix glycoproteins, and proteoglycan. The inappropriate expression of th...

journal_title：Current medicinal chemistry

authors： Yadav RK,Gupta SP,Sharma PK,Patil VM

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:With global increase in elderly population, modern societies must find strategies to reduce the consequences of aging process; thereby decreasing the incidence of age-related neurodegenerative diseases. Oxidative stress and recently inflammation, have been pointed out as the leading causes of brain aging. Th...

journal_title：Current medicinal chemistry

authors： Sarubbo F,Moranta D,Asensio VJ,Miralles A,Esteban S

更新日期：2017-01-01 00:00:00

abstract：:Now cisplatin and its analogs are some of the most effective chemotherapeutic agents in clinical use as the first line of treatment in testicular and ovarian cancers. Unfortunately, they have several major drawbacks, such as cumulative toxicities of nephrotoxicity and ototoxicity, inherent or treatment-induced resista...

journal_title：Current medicinal chemistry

authors： Zhang J,Zhang F,Li H,Liu C,Xia J,Ma L,Chu W,Zhang Z,Chen C,Li S,Wang S

更新日期：2012-01-01 00:00:00

abstract：:T helper (Th) cells belong to the adaptive immune system and provide an effective and antigen-specific means of host protection. Th17 cells are a subset of Th cells, characterized by the production of the inflammatory cytokines interleukin (IL)-17A (IL-17A) and IL-17F, which bind to a receptor complex comprised of IL-...

journal_title：Current medicinal chemistry

authors： Ghali JR,Holdsworth SR,Kitching AR

更新日期：2015-01-01 00:00:00

abstract：: ...

journal_title：Current medicinal chemistry

authors： Stepnowski P,Paszkiewicz M

更新日期：2019-01-01 00:00:00

abstract：:G protein coupled receptors (GPCRs) are a large eukaryotic protein family of transmembrane receptors that react to a signal coming from the extracellular environment to generate an intracellular response through the activation of a signal transduction pathway mediated by a heterotrimeric G protein. Their diversity, di...

journal_title：Current medicinal chemistry

authors： Vanni S,Rothlisberger U

更新日期：2012-01-01 00:00:00

abstract：:Schizophrenia is a chronic psychiatric disorder that affects about 1 in 100 people around the world and results in persistent emotional and cognitive impairments. Untreated schizophrenia leads to deterioration in quality of life and premature death. Although the clinical efficacy of dopamine D2 receptor antagonists ag...

journal_title：Current medicinal chemistry

authors： Jankowska A,Satała G,Partyka A,Wesołowska A,Bojarski AJ,Pawłowski M,Chłoń-Rzepa G

更新日期：2019-01-01 00:00:00

abstract：:Natural products are regarded as vital key source of lead compounds for drug discovery due to their structural diversity and broad array of biological activities. Phenylpropanoid sucrose esters are naturally occurring compounds isolated from various plants and are structurally characterized by a sucrose core connected...

journal_title：Current medicinal chemistry

authors： Panda P,Appalashetti M,Judeh ZM

更新日期：2011-01-01 00:00:00

abstract：:Hyperlipidemia is characterized by abnormally increased plasma of any or all lipids and /or lipoproteins and is a confirmed risk factor for the formation of atherosclerosis. Inflammation plays a crucial role in the formation and progression of atherosclerosis and consequently on cardiovascular diseases. Nowadays, the ...

journal_title：Current medicinal chemistry

authors： Papapanagiotou A,Siasos G,Kassi E,Gargalionis AN,Papavassiliou AG

更新日期：2015-01-01 00:00:00

abstract：:The peroxisome proliferator-activated receptor (PPAR) family of nuclear receptors, a set of three receptor sub-types encoded by distinct genes, function as lipid sensors to regulate a broad range of genes in many metabolically active tissues. Synthetic PPAR agonists have exhibited therapeutic benefits in treating diab...

journal_title：Current medicinal chemistry

authors： Shearer BG,Hoekstra WJ

更新日期：2003-02-01 00:00:00

abstract：:We apply noval techniques, the Scaling Index Method (SIM), which reveals local topology of the structure, and the Minkowski Functionals (MF), which provide four global topological characteristics, to assess strength of the trabecular network of the human bone. We compare capabilities of these methods with the standard...

journal_title：Current medicinal chemistry

authors： Sidorenko I,Monetti R,Bauer J,Mueller D,Rummeny E,Eckstein F,Matsuura M,Lochmueller EM,Zysset P,Raeth C

更新日期：2011-01-01 00:00:00

abstract：:With many advantages over other therapeutic agents such as monoclonal antibodies, aptamers have recently emerged as a novel and powerful class of ligands with excellent potential for diagnostic and therapeutic applications. Typically generated through Systematic Evolution of Ligands by EXponential enrichment (SELEX), ...

journal_title：Current medicinal chemistry

authors： Wang P,Yang Y,Hong H,Zhang Y,Cai W,Fang D

更新日期：2011-01-01 00:00:00

abstract：:Nutritional iron deficiency represents a relevant health problem mainly in developing countries. Children and pregnant women represent the main target of this disease, and the low amount of bio-available iron mostly depends on plant-based diets. Iron deficiency may have serious consequences, with severe impairment of ...

journal_title：Current medicinal chemistry

authors： Lachowicz JI,Nurchi VM,Fanni D,Gerosa C,Peana M,Zoroddu MA

更新日期：2014-01-01 00:00:00

abstract：:In modern industrialized societies, people are exposed to thousands of naturally occurring and synthetic chemicals throughout their lifetime. Although certain occupational chemicals are known to be carcinogenic in humans, it has been difficult to definitively determine the adverse health effects of many environmental ...

journal_title：Current medicinal chemistry

authors： Weyandt J,Ellsworth RE,Hooke JA,Shriver CD,Ellsworth DL

更新日期：2008-01-01 00:00:00

abstract：:Since the beginning of the 20th century, important medicinal progress has led medical doctors to think that the end of devastating epidemics has arrived. In 1930, the discovery of sulfamides and penicillin opened a wide area of applications able to fight against bacterial infections. However, almost all antibiotics we...

journal_title：Current medicinal chemistry

authors： Salzet M

更新日期：2005-01-01 00:00:00

abstract：:Transglutaminases (TGases) are enzymes which catalyze the cross linking of a glutaminyl residue of a protein/peptide substrate to a lysyl residue of a protein/peptide co-substrate with the formation of an N-gamma-(epsilon-L-glutamyl)-L-lysine [GGEL] cross link (isopeptidic bond) and the concomitant release of ammonia....

journal_title：Current medicinal chemistry

authors： Martin A,Romito G,Pepe I,De Vivo G,Merola MR,Limatola A,Gentile V

更新日期：2006-01-01 00:00:00

abstract：:DNA mutation is a very important step in carcinogenesis and elevated levels of oxidative DNA damage have been monitored in a variety of tumors. The discovery of the role of free radicals in cancer has led to a new medical approach. Minimizing oxidative damage may be a significant advance in the prevention or treatment...

journal_title：Current medicinal chemistry

authors： Tekiner-Gulbas B,Westwell AD,Suzen S

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Cholesterol efflux as a key event in reverse cholesterol transport (RCT) is considered now as both diagnostic tool and a promising target for the treatment of atherosclerosis. Radioactive in vitro cholesterol efflux assay (CEA) is the gold standard for determination of efflux at cellular level. Fluorescent t...

journal_title：Current medicinal chemistry

authors： Litvinov DY,Savushkin EV,Garaeva EA,Dergunov AD

更新日期：2016-01-01 00:00:00

abstract：:Genetic, experimental and clinical studies have consistently confirmed that inhibition of Proprotein Convertase Subtilisin/Kexin type 9 (PCSK9) can result in significant lowering of LDL-C and two fully human PCSK9 monoclonal antibodies have received regulatory approval for use in highrisk patients. Co-administration o...

journal_title：Current medicinal chemistry

authors： Panagiotopoulou O,Chiesa ST,Tousoulis D,Charakida M

更新日期：2020-01-01 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is an age-related neurodegenerative disorder that is believed to have complex genetic and environmental influences in the pathogenesis, but etiologies are unidentified for most patients. Until the major causes are better defined, drug development is directed at downstream pathophysi...

journal_title：Current medicinal chemistry

authors： Blasco H,Mavel S,Corcia P,Gordon PH

更新日期：2014-01-01 00:00:00

abstract：:Glycosaminoglycans, highly charged polycarboxylated, polysulfated polysaccharides, are an important class of therapeutic agents and investigational drug candidates. Heparin has been widely used as a clinical anticoagulant for over 60 years. Low molecular weight heparins have begun to displace heparin and recently a sy...

journal_title：Current medicinal chemistry

authors： Karst NA,Linhardt RJ

更新日期：2003-10-01 00:00:00

abstract：:Inosine monophosphate dehydrogenase (IMPDH) catalyzes the conversion of IMP to XMP with the concomitant reduction of NAD to NADH. This reaction is the rate-limiting step in guanine nucleotide biosynthesis. IMPDH is a proven target for immunosuppressive, anticancer and antiviral chemotherapy, and may also be a target f...

journal_title：Current medicinal chemistry

authors： Hedstrom L

更新日期：1999-07-01 00:00:00

abstract：:The alphavbeta3 receptor, which are members of the group of the cellular adhesion molecules (CAM), are heterodimeric transmembrane glycoprotein receptors involved in processes such as cell-cell and cell-matrix adhesion, cell migration and signaling. Integrin alphavbeta3 receptor is expressed on almost all cells origin...

journal_title：Current medicinal chemistry

authors： Cacciari B,Spalluto G

更新日期：2005-01-01 00:00:00

abstract：:Inflammation plays a critical role in the atherosclerotic process in various vascular beds, starting from endothelial dysfunction and counting all stages of plaque development. The significant contribution of inflammation in the initiation and progression of atherosclerosis has been documented over many years but its ...

journal_title：Current medicinal chemistry

authors： Vavuranakis M,Kariori M,Vrachatis D,Siasos G,Kalogeras K,Bei E,Moldovan C,Lavda M,Aznaouridis K,Oikonomou E,Tousoulis D

更新日期：2015-01-01 00:00:00