Abstract:
:Hyperlipidemia is characterized by abnormally increased plasma of any or all lipids and /or lipoproteins and is a confirmed risk factor for the formation of atherosclerosis. Inflammation plays a crucial role in the formation and progression of atherosclerosis and consequently on cardiovascular diseases. Nowadays, the effective role of the immune system and subsequently of systemic inflammation is well established. Multiple levels of evidence from experimental models and histopathologic assessment of tissues to systemic biomarkers and epidemiologic or clinical associations have revealed that inflammation is one of the basic mechanisms in the destabilization of the atherogenetic plaque which leads to clinical events. Several inflammatory markers are affiliated with lipids level and the process of atherosclerosis. The most known of them are interleukin 6 and interleukin 1β, C-reactive protein, tumor necrosis factor-alpha, pentraxin3, serum amyloid A, sCD40, adhesion molecules, monocyte chemoattractant protein-1, sEndoglin, PAPP-A, chemokine 16, insulin like growth factor, lipoprotein-associated phospholipase A2 and galectin 3 but their role in atherogenesis is not well established for all of them. As atheromatosis is one of the main causes of death all over the world, in upcoming studies it will be useful to specify the exact role of these markers in this process in order to have a better prognosis, diagnosis and understanding of this disorder. The aim in this review is to study the literature on the novel inflammation markers of hyperlipidemia according to their clinical implications.
journal_name
Curr Med Chemjournal_title
Current medicinal chemistryauthors
Papapanagiotou A,Siasos G,Kassi E,Gargalionis AN,Papavassiliou AGdoi
10.2174/0929867322666150520095008subject
Has Abstractpub_date
2015-01-01 00:00:00pages
2727-43issue
23eissn
0929-8673issn
1875-533Xpii
CMC-EPUB-67485journal_volume
22pub_type
杂志文章,评审abstract::Cell products are live cells that are given to patients in order to replace or modify the function of missing or dysfunctional cells. Progress in technology and in the understanding of pathobiology may lead to the use of cell products in many areas. This review outlines the use of cell products in the treatment of aut...
journal_title:Current medicinal chemistry
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abstract:BACKGROUND:During lead identification and optimization, the advancement criteria may be driven based on scientific principles, prior experiences, and/or by examining the path paved by approved drugs. However, accessing the discovery data on physicochemical and ADME properties of the approved kinase inhibitors is a monu...
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journal_title:Current medicinal chemistry
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journal_title:Current medicinal chemistry
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journal_title:Current medicinal chemistry
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更新日期:2011-01-01 00:00:00
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journal_title:Current medicinal chemistry
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更新日期:2014-01-01 00:00:00
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更新日期:2013-01-01 00:00:00
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更新日期:2007-01-01 00:00:00
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更新日期:2014-04-01 00:00:00
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journal_title:Current medicinal chemistry
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更新日期:2018-01-01 00:00:00
abstract::Heterocyclic compounds represent a significant target for anti-cancer research and drug discovery, due to their structural and chemical diversity. Oxazoles, with oxygen and nitrogen atoms present in the core structure, enable various types of interactions with different enzymes and receptors, favoring the discovery of...
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更新日期:2019-01-01 00:00:00
abstract::Hydrogen sulfide (H2S), previously known only as a toxic agent, in the last decades has been recognized as an important endogenous gasotransmitter, playing a key role in the homeostasis of the cardiovascular system. In the last years, the growing evidence about a protective role exhibited by H2S against myocardial isc...
journal_title:Current medicinal chemistry
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更新日期:2000-04-01 00:00:00
abstract::Giving a glance to the report of Wound Care Market by Product updated in 2017, we can see that wound care market is expected to reach USD 22.01 billion by 2022 from USD 18.35 billion at a CAGR of 3.7%. Numerous factors are driving the growth of this market, including the increasing prevalence of chronic wounds and acu...
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更新日期:2019-01-01 00:00:00
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更新日期:2012-01-01 00:00:00
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journal_title:Current medicinal chemistry
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更新日期:2012-01-01 00:00:00
abstract:BACKGROUND:Chronic, degenerative diseases are often characterized by inflammation and aberrant angiogenesis. For these pathologies, including rheumatoid arthritis, cardiovascular and autoimmune diseases, cancer, diabetes, and obesity, current therapies have limited efficacy. OBJECTIVES:The validation of novel (chemo)p...
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更新日期:2019-01-01 00:00:00