Nutritional iron deficiency: the role of oral iron supplementation.

abstract：:The use of anti-diabetic drugs has been increasing worldwide and the evolution of therapeutics has been enormous. Still, the currently available anti-diabetic drugs do not present the desired efficacy and are generally associated with serious adverse effects. Thus, entirely new interventions, addressing the underlying...

journal_title：Current medicinal chemistry

authors： Rocha S,Ribeiro D,Fernandes E,Freitas M

更新日期：2020-01-01 00:00:00

abstract：:Genetic, experimental and clinical studies have consistently confirmed that inhibition of Proprotein Convertase Subtilisin/Kexin type 9 (PCSK9) can result in significant lowering of LDL-C and two fully human PCSK9 monoclonal antibodies have received regulatory approval for use in highrisk patients. Co-administration o...

journal_title：Current medicinal chemistry

authors： Panagiotopoulou O,Chiesa ST,Tousoulis D,Charakida M

更新日期：2020-01-01 00:00:00

abstract：:Stress or heat shock proteins (Hsps) Hsp90, Hsp70 and Hsp27 are chaperones that assist the proteins in their folding, stability, assembly into multi-protein complexes and transport across cellular membranes. The expression of some of them is highly induced in response to a wide variety of physiological and environment...

journal_title：Current medicinal chemistry

authors： Didelot C,Lanneau D,Brunet M,Joly AL,De Thonel A,Chiosis G,Garrido C

更新日期：2007-01-01 00:00:00

abstract：:To date, many scientific attempts have been directed towards the development of experimental models for the identification of neuronal mechanisms evoking cardiovascular and hemodynamic dysfunctions. The spontaneously hypertensive rat (SHR), a genetic model of essential hypertension, has become a valuable rodent for th...

journal_title：Current medicinal chemistry

authors： Giusi G,Alò R,Avolio E,Zizza M,Facciolo RM,Talani G,Biggio G,Sanna E,Canonaco M

更新日期：2012-01-01 00:00:00

abstract：:Leukemia is a life threatening disease that has become increasingly common. Many categories of anti-leukemic agents have been developed by probing into the nature of leukemia. Nevertheless, the needs for potent molecules with few side effects are still not satisfied in the current anti-leukemic therapy. Targeted thera...

journal_title：Current medicinal chemistry

authors： Bian J,Zhang L,Han Y,Wang C,Zhang L

更新日期：2015-01-01 00:00:00

abstract：:Nowadays, the use of synthetic carriers as biochemical reagents and immunogens is entering a new phase. The multimeric nature of these constructs, the unambiguous composition and the ease, reliability and versatility of their production, make this type of carriers well-suited to various biotechnological and biochemica...

journal_title：Current medicinal chemistry

authors： Alexopoulos Ch,Sakarellos-Daitsiotis M,Sakarellos C

更新日期：2005-01-01 00:00:00

abstract：:Excitatory neurotransmission mediated by NMDA (N-methyl-D-aspartic acid) receptors plays a key role in both healthy and diseased processes in the brain. Therefore, bioactive compounds that can interact selectively with these receptors have been the aim of extensive research in the search of effective therapeutic agent...

journal_title：Current medicinal chemistry

authors： Bonaccorso C,Micale N,Ettari R,Grasso S,Zappalà M

更新日期：2011-01-01 00:00:00

abstract：:Non-small cell lung cancer (NSCLC) remains a fatal disease: the majority of patients are diagnosed as having metastases or advanced inoperable tumors. The activity of chemotherapy in NSCLC patients is low with objective response rarely complete and sustained. Cisplatin-based combinations are considered as the standard...

journal_title：Current medicinal chemistry

authors： Gridelli C,De Vivo R

更新日期：2002-04-01 00:00:00

abstract：:Since its discovery, peroxynitrite has been known as a potent oxidant in biological systems, and a rapidly growing body of literature has characterized its biochemistry and role in the pathophysiology of various conditions. Either directly or by inducing free radical pathways, peroxynitrite damages vital biomolecules ...

journal_title：Current medicinal chemistry

authors： Stadler K

更新日期：2011-01-01 00:00:00

abstract：:Deregulation of kinase function has been implicated in several important diseases, including cancer, neurological and metabolic disorders. Because of their key role in causing disease, kinases have become one of the most intensively pursued classes of drug targets. To date, several monoclonal antibodies (mAbs) and sma...

journal_title：Current medicinal chemistry

authors： Cerchia L,de Franciscis V

更新日期：2011-01-01 00:00:00

abstract：:Artificial intelligence methods, in particular, machine learning, has been playing a pivotal role in drug development, from structural design to clinical trial. This approach is harnessing the impact of computer-aided drug discovery thanks to large available data sets for drug candidates and its new and complex manner...

journal_title：Current medicinal chemistry

authors： Musella S,Verna G,Fasano A,Di Micco S

更新日期：2020-11-11 00:00:00

abstract：:The hyaluronidases (HAases) are a group of less extensively studied glycosidases distributed throughout the animal kingdom and are popularly known as 'spreading factors'. In recent years, HAases received much attention due to their ability to abruptly alter the hyaluronic acid (HA) homeostasis. HAases preferentially d...

journal_title：Current medicinal chemistry

authors： Girish KS,Kemparaju K,Nagaraju S,Vishwanath BS

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:The genus Achillea L. is rich in bioactive sesquiterpenes and flavonoids; most of the studied species exhibit several biological activities and are used as emmenagogue, wound healing and analgesic agents. Some species are also used in local folklore medicine. OBJECTIVE:Following a literature survey, we disc...

journal_title：Current medicinal chemistry

authors： Papakosta K,Grafakou ME,Barda C,Kostopoulos IV,Tsitsilonis O,Skaltsa H

更新日期：2020-01-01 00:00:00

abstract：:Osteoporosis is a pathological loss of bone mass due to an imbalance in bone remodeling where osteoclast-mediated bone resorption exceeds osteoblast-mediated bone formation resulting in skeletal fragility and fractures. Anti-resorptive agents such as bisphosphonates and SERMs, and anabolic drugs that stimulate bone fo...

journal_title：Current medicinal chemistry

authors： Li H,Xiao Z,Quarles LD,Li W

更新日期：2020-03-30 00:00:00

abstract：:A challenging question in biology is how cells control their shape and volume. The relative abundance of organelles can be radically modified to comply with a new task, an example being the massive development of the endoplasmic reticulum (ER) in Ig-secreting plasma cells. The ER is the site where secretory proteins a...

journal_title：Current medicinal chemistry

authors： Otsu M,Sitia R

更新日期：2007-01-01 00:00:00

abstract：:The discovery of cannabinoid receptors at the beginning of the 1990s, CB1 cloned in 1990 and CB2 cloned in 1993, and the availability of selective and potent cannabimimetics could only be justified by the existence of endogenous ligands that are capable of binding to them. Thus, the characterisation and cloning of the...

journal_title：Current medicinal chemistry

authors： Páez JA,Campillo NE

更新日期：2019-01-01 00:00:00

abstract：:Ageing is an aggravating factor leading to alterations in the biotransformation of drugs, and therefore their therapeutic efficacy and safety. In this review we discuss the influence of ageing on drug metabolizing enzymes in male Wistar rats. We report that drug metabolizing enzymes can be affected by ageing either by...

journal_title：Current medicinal chemistry

authors： Wauthier V,Verbeeck RK,Calderon PB

更新日期：2007-01-01 00:00:00

abstract：:Cinnamic acid and its phenolic analogues are natural substances. Chemically, in cinnamic acids the 3-phenyl acrylic acid functionality offers three main reactive sites; substitution at the phenyl ring, addition at the α,β- unsaturation and the reactions of the carboxylic acid functionality. Owing to these chemical asp...

journal_title：Current medicinal chemistry

authors： De P,Baltas M,Bedos-Belval F

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:Nitric oxide (NO) plays important regulatory roles in a plethora of biological functions and thus holds tremendous potential to be exploited for clinical uses. However, the chemistries in the molecular design of nano-nitric oxide delivery systems is currently lacking. OBJECTIVE:The overarching aim of this r...

journal_title：Current medicinal chemistry

authors： Nguyen KT,Wu Z,Huang T,Tay CY

更新日期：2018-01-01 00:00:00

abstract：:APN is an important zinc dependent metallo-exopeptidase; it has been considered as a suitable target for anti-cancer drug design. In this review we focus on the most effective and the most promising inhibitors of aminopeptidase N. Their binding modes to the enzyme, the attempt to explain the origin of the inhibitory a...

journal_title：Current medicinal chemistry

authors： Zhang X,Xu W

更新日期：2008-01-01 00:00:00

abstract：:In order to ascertain the role of dietary flavonoids as antioxidants in vivo it is necessary to understand the chemical nature of the absorbed forms in the circulation in vivo and how the multiplicity of research findings in vitro reflect the bioactivity of flavonoids in vivo. Only when we gain adequate information on...

journal_title：Current medicinal chemistry

authors： Rice-Evans C

更新日期：2001-06-01 00:00:00

abstract：:Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection has been a global challenge. The complicated forms of the Coronavirus Disease 2019 (COVID-19) can evolve to multiple-organ failure, including several coagulopathies related to a sudden worsening of respiratory status. This article aimed to review s...

journal_title：Current medicinal chemistry

authors： Pena ALB,Oliveira RA,Severo RG,Simões E Silva AC

更新日期：2020-10-05 00:00:00

abstract：:Nowadays, fast and sensitive methods for biomarkers detection exist, but the performance of most of them still rely centralized laboratory testing. The development of small, fast and simple to use medical devices that can help in making diagnosis accurate and with low-invasiveness is now a major challenge for nanotech...

journal_title：Current medicinal chemistry

authors： Bedin C,Crotti S,Tasciotti E,Agostini M

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:Immunomodulation is one of the significant therapeutic strategies. It includes both stimulation and suppression of the immune system by a variety of substances called immunomodulators, designed to regulate the immune response of the organism against infections of varying etiology. An example of such a substa...

journal_title：Current medicinal chemistry

authors： Siebert A,Gensicka-Kowalewska M,Cholewinski G,Dzierzbicka K

更新日期：2017-11-17 00:00:00

abstract：:Neonatal brain hemorrhage (NBH) of prematurity is an unfortunate consequence of preterm birth. Complications result in shunt dependence and long-term structural changes such as posthemorrhagic hydrocephalus, periventricular leukomalacia, gliosis, and neurological dysfunction. Several animal models are available to stu...

journal_title：Current medicinal chemistry

authors： Lekic T,Klebe D,Poblete R,Krafft PR,Rolland WB,Tang J,Zhang JH

更新日期：2015-01-01 00:00:00

abstract：:In their structural multiplicity and in the extent to which they occur in nature the derivatives of benzofuran are significantly lesser than the isoelectronic analogue indoles. However, these heterocyclic compounds show a variety of pharmacological properties, and change of their structure offers a high degree of dive...

journal_title：Current medicinal chemistry

authors： De Luca L,Nieddu G,Porcheddu A,Giacomelli G

更新日期：2009-01-01 00:00:00

abstract：:Sulfonyl group-containing compounds constitute an important class of therapeutical agents in medicinal chemistry presumably because of the tense chemical structure and functionality of the sulfonyl, which could not only form hydrogen bonding interactions with active site residues of biological targets but also, as inc...

journal_title：Current medicinal chemistry

authors： Chen X,Hussain S,Parveen S,Zhang S,Yang Y,Zhu C

更新日期：2012-01-01 00:00:00

abstract：:Tumor necrosis factor (TNF) is a cytokine with well known anticancer properties and is being utilized as anticancer agent for the treatment of patients with locally advanced solid tumors. However, TNF role in cancer biology is debated. In fact, in spite of the wealth of evidence supporting its antitumor activity, the ...

journal_title：Current medicinal chemistry

authors： Bertazza L,Mocellin S

更新日期：2010-01-01 00:00:00

abstract：:A series of potential topoisomerase II-mediated anticancer 9-anilinoacridine derivatives, which are designed to avoid bio-oxidation and possessed long duration of drug action, is reviewed. Among these agents, 3-(9-acridinylamino)-5-hydroxymethylaniline (AHMA) derivatives and their alkylcarbamates have been investigate...

journal_title：Current medicinal chemistry

authors： Su TL

更新日期：2002-09-01 00:00:00

abstract：BACKGROUND:Vaccines are very effective medical tools for disease prevention and life span increase. Controversies have raised concern about their safety, from autism to polio vaccine contamination with simian virus 40 (SV-40). Hysteria surrounding vaccine-associated risks has resulted in a declining number of vaccinati...

journal_title：Current medicinal chemistry

authors： Pandolfi F,Franza L,Todi L,Carusi V,Centrone M,Buonomo A,Chini R,Newton EE,Schiavino D,Nucera E

更新日期：2018-01-01 00:00:00