Perspectives on Drug Repurposing.

abstract：:Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection has been a global challenge. The complicated forms of the Coronavirus Disease 2019 (COVID-19) can evolve to multiple-organ failure, including several coagulopathies related to a sudden worsening of respiratory status. This article aimed to review s...

journal_title：Current medicinal chemistry

authors： Pena ALB,Oliveira RA,Severo RG,Simões E Silva AC

更新日期：2020-10-05 00:00:00

abstract：:Thalidomide (N-alpha-phthalimidoglutarimide) was used widely as a hypnotic/sedative agent in the late 1950s and the early 1960s, but had to be withdrawn from the market because of its severe teratogenicity. In spite of this, there has been a resurgence of interest in the drug in recent years due to its potential usefu...

journal_title：Current medicinal chemistry

authors： Hashimoto Y

更新日期：1998-06-01 00:00:00

abstract：:Nowadays, fast and sensitive methods for biomarkers detection exist, but the performance of most of them still rely centralized laboratory testing. The development of small, fast and simple to use medical devices that can help in making diagnosis accurate and with low-invasiveness is now a major challenge for nanotech...

journal_title：Current medicinal chemistry

authors： Bedin C,Crotti S,Tasciotti E,Agostini M

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:Excessive norepinephrine (NE) release in the ischemic heart elicits severe and often lethal arrhythmias. Resident cardiac mast cells synthesize and store active renin, which is released upon degranulation, causing the activation of a local cardiac renin-angiotensin system (RAS) responsible for NE release and...

journal_title：Current medicinal chemistry

authors： Marino A,Levi R

更新日期：2018-01-01 00:00:00

abstract：:Ten years elapsed since the discovery by Sanofi of SR141716A the first selective CB(1) cannabinoid receptor antagonist. Shortly after, Sanofi also reported the synthesis of the first selective CB(2) cannabinoid receptor antagonist, SR144528. Since these two milestones in the cannabinoid field, many other compounds, mo...

journal_title：Current medicinal chemistry

authors： Muccioli GG,Lambert DM

更新日期：2005-01-01 00:00:00

abstract：:The present review aims to provide a complete and comprehensive summary of current literature relevant to oxysterols and related diseases. Oxidation of cholesterol leads to the formation of a large number of oxidized products, generally known as oxysterols. They are intermediates in the biosynthesis of bile acids, ste...

journal_title：Current medicinal chemistry

authors： Samadi A,Sabuncuoglu S,Samadi M,Isikhan SY,Chirumbolo S,Peana M,Lay I,Yalcinkaya A,Bjørklund G

更新日期：2021-01-01 00:00:00

abstract：BACKGROUND:Hepatocellular Carcinoma (HCC) is one of the greatest global health burdens because of its uncontrolled cell growth and proliferation, aggressive nature as well as inherited chemoresistance. In spite of different treatment options currently available for HCC, the 5-year relative survival rates for HCC patien...

journal_title：Current medicinal chemistry

authors： Grbčić P,Car EPM,Sedić M

更新日期：2020-01-01 00:00:00

abstract：:Atrial fibrillation (AF) is the most common arrhythmia in clinical practice. It can occur at any age, however, it becomes extremely common in the elderly, with a prevalence approaching more than 20% in patients older than 85 years. AF is associated with a wide range of cardiac and extra-cardiac complications and there...

journal_title：Current medicinal chemistry

authors： Jost N,Kohajda Z,Kristóf A,Kovács PP,Husti Z,Juhász V,Kiss L,Varró A,Virág L,Baczkó I

更新日期：2011-01-01 00:00:00

abstract：:Tuberculosis (TB) is the leading cause of mortality due to a single infectious agent. The currently used combination drug regimens produce cure rates that exceed 95%, given good patient adherence during the multiple months treatment period. However the recent surge in HIV infections and the synergy between HIV and TB ...

journal_title：Current medicinal chemistry

authors： Budha NR,Lee RE,Meibohm B

更新日期：2008-01-01 00:00:00

abstract：:The introduction of highly active antiretroviral therapy (HAART) in 1996 dramatically changed the course of HIV infection. This therapy involves the use of at least three agents from two distinct classes of antivirals: a protease inhibitor (PI) in combination with two nucleoside/nucleotide reverse transcriptase inhibi...

journal_title：Current medicinal chemistry

authors： Mastrolorenzo A,Rusconi S,Scozzafava A,Barbaro G,Supuran CT

更新日期：2007-01-01 00:00:00

abstract：:In order to ascertain the role of dietary flavonoids as antioxidants in vivo it is necessary to understand the chemical nature of the absorbed forms in the circulation in vivo and how the multiplicity of research findings in vitro reflect the bioactivity of flavonoids in vivo. Only when we gain adequate information on...

journal_title：Current medicinal chemistry

authors： Rice-Evans C

更新日期：2001-06-01 00:00:00

abstract：:RNA aptamers are non-coding small RNAs that bind to their cognate targets with high specificity and affinity. They are generally identified by iterative rounds of in vitro selection termed SELEX (Systemic Evolution of Ligands by Exponential Enrichment). Similar to antibodies, they can inhibit, modulate and disrupt the...

journal_title：Current medicinal chemistry

authors： Li Y,Wu H,Niu Y,Hu Y,Li Q,Cao C,Cai J

更新日期：2013-01-01 00:00:00

abstract：:Recent advances in endoscopic techniques such as capsule endoscopy have revealed that aspirin and other nonsteroidal antiinflammatory drugs (NSAIDs) often cause mucosal lesions not only in the upper gastrointestinal tract, but also in the small intestine in humans. Gastric and duodenal lesions caused by NSAIDs can be ...

journal_title：Current medicinal chemistry

authors： Satoh H,Takeuchi K

更新日期：2012-01-01 00:00:00

abstract：:Normal somatic stem cells (SC) are naturally resistant to chemotherapeutic agents due to their expression of various membrane transporter molecules (such as MDR-1), detoxifying enzymes and DNA repair proteins. In addition, they also have a slow rate of cell turnover and therefore escape from chemotherapeutic agents th...

journal_title：Current medicinal chemistry

authors： Gangemi R,Paleari L,Orengo AM,Cesario A,Chessa L,Ferrini S,Russo P

更新日期：2009-01-01 00:00:00

abstract：:The role of cell adhesion molecules (CAMs), such as intercellular cell adhesion molecule-1 (ICAM-1), vascular endothelial cell adhesion molecule-1 (VCAM-1), E-selectin, and P-selectin, has been studied extensively in the process of inflammation. These molecules are responsible for recruiting leukocytes onto the vascul...

journal_title：Current medicinal chemistry

authors： Kobayashi H,Boelte KC,Lin PC

更新日期：2007-01-01 00:00:00

abstract：:Mitochondria are organelles which play an important role not only in cellular metabolism but also in controlling pathways related with cell death, ionic and redox regulation. Alterations in mitochondrial metabolism are implicated in a variety of diseases, including cancer. Cellular and mitochondrial metabolism are bot...

journal_title：Current medicinal chemistry

authors： Deus CM,Santos GL,Loureiro R,Vega-Naredo I,Faneca H,Oliveira PJ

更新日期：2015-01-01 00:00:00

abstract：:Over the last centuries, there were many important discoveries in medicine that were crucial for gaining a better understanding of several physiological processes. Molecular modelling techniques are powerful tools that have been successfully used to analyse and interface medicinal chemistry studies with electrochemica...

journal_title：Current medicinal chemistry

authors： Almeida MO,Maltarollo VG,de Toledo RA,Shim H,Santos MC,Honorio KM

更新日期：2014-01-01 00:00:00

abstract：:The clinical treatment of multifactorial pathologies (e.g. cancer, Alzheimer's disease, psychiatric disorders), is still a major challenge. Many researches have been published dealing with the design of multiple ligands, able to act at the same time towards several targets relevant for a given pathology. In the presen...

journal_title：Current medicinal chemistry

authors： Costantino L,Barlocco D

更新日期：2012-01-01 00:00:00

abstract：:The identification and characterisation of the isoenzyme cyclooxygenase 2 (COX-2) stimulated investigations to develop efficient non-steroidal anti-inflammatory drugs with reduced side effects compared to standard NSAIDs. This review will focus on the structural features needed to achieve COX-2 selectivity. Five struc...

journal_title：Current medicinal chemistry

authors： Dannhardt G,Laufer S

更新日期：2000-11-01 00:00:00

abstract：:Despite advances in cancer treatment, a large number of patients eventually develop metastatic disease that is generally incurable. Systemic chemotherapy remains the standard treatment for these patients. Several chemotherapeutic combinations have proven effective in the management of cancer. Paradoxically, although t...

journal_title：Current medicinal chemistry

authors： Prados J,Alvarez PJ,Melguizo C,Rodriguez-Serrano F,Carrillo E,Boulaiz H,Vélez C,Marchal JA,Caba O,Ortiz R,Rama A,Aranega A

更新日期：2012-01-01 00:00:00

abstract：:Modification of cysteine (Cys) residues in proteins, due to (i) the participation of the thiol moiety of this amino acid in oxido-reductions reactions; (ii) its ability to strongly coordinate transition metal ions; or (iii) its nucleophilic nature and facile reaction with electrophiles, may be of critical importance f...

journal_title：Current medicinal chemistry

authors： Scozzafava A,Casini A,Supuran CT

更新日期：2002-06-01 00:00:00

abstract：:Dendritic cells (DCs) are the most powerful antigen-presenting cells which link the innate and adaptive immune responses. Depending on the context DCs initiate the immune responses or contribute to immune tolerance. Any disturbance in their phenotypes and functions may initiate inflammatory or autoimmune diseases. Hen...

journal_title：Current medicinal chemistry

authors： Rahimi K,Hassanzadeh K,Khanbabaei H,Haftcheshmeh SM,Ahmadi A,Izadpanah E,Mohammadi A,Sahebkar A

更新日期：2020-05-14 00:00:00

abstract：BACKGROUND:The genus Achillea L. is rich in bioactive sesquiterpenes and flavonoids; most of the studied species exhibit several biological activities and are used as emmenagogue, wound healing and analgesic agents. Some species are also used in local folklore medicine. OBJECTIVE:Following a literature survey, we disc...

journal_title：Current medicinal chemistry

authors： Papakosta K,Grafakou ME,Barda C,Kostopoulos IV,Tsitsilonis O,Skaltsa H

更新日期：2020-01-01 00:00:00

abstract：:Patients with homozygous familial hypercholesterolemia (HoFH) represent the most severe patients within the spectrum of dyslipidemias. Untreated Low-Density Lipoprotein Cholesterol (LDL-C) levels in these patients are usually in the range 500 to 1200 mg/dL. Moreover, these patients exhibit a scarce responsiveness or e...

journal_title：Current medicinal chemistry

authors： Stefanutti C,Morozzi C,Di Giacomo S

更新日期：2012-01-01 00:00:00

abstract：:Marine organisms are abundant sources of bioactive natural products. Among metabolites produced by sponges and their associated microbial communities, halogenated natural compounds accounted for an important part due to their potent biological activities. The present review updates and compiles a total of 258 halogena...

journal_title：Current medicinal chemistry

authors： Li C,Shi D

更新日期：2020-01-01 00:00:00

abstract：:Complete DNA sequence information has now been obtained for several prokaryotic genomes, defining the entire genetic complement of these organisms. The collection of genomic data has provided new insights into the molecular architecture of bacterial cells, revealing the basic genetic and metabolic structures that supp...

journal_title：Current medicinal chemistry

authors： Buysse JM

更新日期：2001-12-01 00:00:00

abstract：BACKGROUND:Steroid hormones belong to a group of low-molecular weight compounds which are responsible for maintenance of various body functions, thus, their accurate assessment is crucial for evaluation of biosynthetic defects. The development of reliable methods allowing disease diagnosis is essential to improve early...

journal_title：Current medicinal chemistry

authors： Kotłowska A,Szefer P

更新日期：2019-01-01 00:00:00

abstract：: ...

journal_title：Current medicinal chemistry

authors： Stepnowski P,Paszkiewicz M

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Smac mimetics (also known as IAP antagonist) are a new class of targeted drugs having a goal to suppress the IAPs, reestablishing the apoptotic pathways and inducing cancer cell death. Therefore, development of Smac mimetics was considered an attractive strategy for the development of new anticancer drugs. L...

journal_title：Current medicinal chemistry

authors： Ali R,Singh S,Haq W

更新日期：2018-01-01 00:00:00

abstract：:Hydrogen sulfide (H2S), previously known only as a toxic agent, in the last decades has been recognized as an important endogenous gasotransmitter, playing a key role in the homeostasis of the cardiovascular system. In the last years, the growing evidence about a protective role exhibited by H2S against myocardial isc...

journal_title：Current medicinal chemistry

authors： Citi V,Piragine E,Testai L,Breschi MC,Calderone V,Martelli A

更新日期：2018-01-01 00:00:00