Curcumin: a dietary phytochemical for targeting the phenotype and function of dendritic cells.

abstract：OBJECTIVES:Post-exercise cardiac troponin T (cTnT) release has been widely reported in adult athletes but limited data is available for adolescents. The aim of this study was to determine the incidence and magnitude of cTnT appearance in a large group of adolescent runners, and to determine any association between cTnT...

journal_title：Current medicinal chemistry

authors： Nie J,George KP,Tong TK,Gaze D,Tian Y,Lin H,Shi Q

更新日期：2011-01-01 00:00:00

abstract：:Essential oils constituents are a diverse family of low molecular weight organic compounds with comprehensive biological activity. According to their chemical structure, these active compounds can be divided into four major groups: terpenes, terpenoids, phenylpropenes, and "others". In addition, they may contain diver...

journal_title：Current medicinal chemistry

authors： Burčul F,Blažević I,Radan M,Politeo O

更新日期：2020-01-01 00:00:00

abstract：:Ca(2+) is a highly versatile intracellular second messenger in the central nervous system, and regulates many complicated cellular processes, including excitation, plasticity and apoptosis. Influx of Ca(2+) from the extracellular fluid is required for sustained elevation of the cytosolic Ca(2+) concentration and full ...

journal_title：Current medicinal chemistry

authors： Yagami T,Kohma H,Yamamoto Y

更新日期：2012-01-01 00:00:00

abstract：:Nanomedicine is certainly one of the scientific and technological challenges of the coming years. In particular, biodegradable nanoparticles formulated from poly (D,L-lactide-co-glycolide) (PLGA) have been extensively investigated for sustained and targeted delivery of different agents, including recombinant proteins,...

journal_title：Current medicinal chemistry

authors： Tosi G,Bortot B,Ruozi B,Dolcetta D,Vandelli MA,Forni F,Severini GM

更新日期：2013-01-01 00:00:00

abstract：:Nowadays, fast and sensitive methods for biomarkers detection exist, but the performance of most of them still rely centralized laboratory testing. The development of small, fast and simple to use medical devices that can help in making diagnosis accurate and with low-invasiveness is now a major challenge for nanotech...

journal_title：Current medicinal chemistry

authors： Bedin C,Crotti S,Tasciotti E,Agostini M

更新日期：2018-01-01 00:00:00

abstract：:TB drug development pipeline represents varied structural classes of molecules. Oxazolidinones represent synthetic anti-bacterial agents with unique mechanism of action having wide spectrum of activity, oral bioavailability and well established SAR. They act by inhibiting translation at the initiation phase of protein...

journal_title：Current medicinal chemistry

authors： Jadhavar PS,Vaja MD,Dhameliya TM,Chakraborti AK

更新日期：2015-01-01 00:00:00

abstract：:The branched-chain fatty acid valproic acid (VPA) is the most commonly used antiepileptic drug for treating generalized epilepsy. Although originally considered to be of low toxicity, VPA has proved to possess considerable teratogenic potential when applied to the pregnant epileptic women. During the last few years, i...

journal_title：Current medicinal chemistry

authors： Blaheta RA,Nau H,Michaelis M,Cinatl J Jr

更新日期：2002-08-01 00:00:00

abstract：:The discovery of cannabinoid receptors at the beginning of the 1990s, CB1 cloned in 1990 and CB2 cloned in 1993, and the availability of selective and potent cannabimimetics could only be justified by the existence of endogenous ligands that are capable of binding to them. Thus, the characterisation and cloning of the...

journal_title：Current medicinal chemistry

authors： Páez JA,Campillo NE

更新日期：2019-01-01 00:00:00

abstract：:Dipeptidyl peptidase 4 (DPP-4), a substrate-specific serine protease, has been validated as a promising drug target for the treatment of type 2 diabetes. DPP-4 inhibitors significantly lowered blood glucose levels in patients with type 2 diabetes without common body weight gain, hypoglycemia and gastrointestinal distu...

journal_title：Current medicinal chemistry

authors： Liu Y,Hu Y,Liu T

更新日期：2012-01-01 00:00:00

abstract：:A large number of children in the autism spectrum disorder suffer from gastrointestinal (GI) conditions, such as constipation and diarrhea. Clostridium bolteae is a part of a set of pathogens being regularly detected in the stool samples of hosts affected by GI and autism symptoms. Accompanying studies have pointed ou...

journal_title：Current medicinal chemistry

authors： Pequegnat B,Monteiro MA

更新日期：2019-01-01 00:00:00

abstract：:The role of MRI in the armory of diagnostic modalities for the medicine of the forthcoming years largely depends on how chemistry will provide advanced tools to meet the medical needs. This review aims at outlining the most innovative approaches that have been undertaken in the recent history of MRI contrast agents fo...

journal_title：Current medicinal chemistry

authors： Terreno E,Dastrù W,Delli Castelli D,Gianolio E,Geninatti Crich S,Longo D,Aime S

更新日期：2010-01-01 00:00:00

abstract：:The new drug class of dipeptidyl peptidase-4 (DPP4) inhibitors has been widely accepted in the daily management of type 2 diabetes since its strategic advantages with regard to body weight, risk of hypoglycaemia, and beta cell survival. We have previously evaluated the theoretical implications of DPP4 inhibition given...

journal_title：Current medicinal chemistry

authors： Matteucci E,Giampietro O

更新日期：2011-01-01 00:00:00

abstract：:Characterization of liver-specific autoantigens has given a fresh impetus to research in the pathogenesis of autoimmune liver diseases, viral-triggered and drug-induced autoimmunity affecting the liver. Intriguing is the fact that most of the liver-specific autoantigens are enzymes of key importance for cell's homeost...

journal_title：Current medicinal chemistry

authors： Bogdanos DP,Dalekos GN

更新日期：2008-01-01 00:00:00

abstract：:Amyloid beta peptide (Aβ) is recognised as a main feature of Alzheimer's disease (AD). Increasing evidence suggests that small soluble oligomers of Aβ are the toxic form of the peptide and may instigate AD. Different factors including some key residues within Aβ molecule, the cell membrane, prion protein and metals pl...

journal_title：Current medicinal chemistry

authors： Jamasbi E,Wade JD,Separovic F,Hossain MA

更新日期：2016-01-01 00:00:00

abstract：:A challenging question in biology is how cells control their shape and volume. The relative abundance of organelles can be radically modified to comply with a new task, an example being the massive development of the endoplasmic reticulum (ER) in Ig-secreting plasma cells. The ER is the site where secretory proteins a...

journal_title：Current medicinal chemistry

authors： Otsu M,Sitia R

更新日期：2007-01-01 00:00:00

abstract：:gammadelta T lymphocytes are involved in the defence from viral and mycobacterial infections; however they are also responsible for autoimmune reactions. Herein, we discuss the characteristics of these cells, focusing on the mechanism(s) underlying extravasation and tissue localization. We show that Vdelta1 and Vdelta...

journal_title：Current medicinal chemistry

authors： Poggi A,Catellani S,Fenoglio D,Borsellino G,Battistini L,Zocchi MR

更新日期：2007-01-01 00:00:00

abstract：:Bipolar disorder (BD) is a long-term illness with mood swings which are characterized by recurrent episodes of mania/hypomania and depression, with variable interpolations of relatively asymptomatic periods, called euthymic, in which, however, some psychopathological symptoms may persist. Although mood stabilizers, su...

journal_title：Current medicinal chemistry

authors： Musenga A,Saracino MA,Sani G,Raggi MA

更新日期：2009-01-01 00:00:00

abstract：:Breast cancer arises in about 48% of patients older than 65 years and more than 30% occurs in those over 70 years being the leading cause of cancer-related death in women older than 65. Elderly patients tolerate chemotherapy poorly compared to their younger counterpart because of progressive reduction of organ functio...

journal_title：Current medicinal chemistry

authors： Rossi A,Colantuoni G,Maione P,Ferrara C,Airoma G,Barzelloni ML,Castaldo V,Gridelli C

更新日期：2005-01-01 00:00:00

abstract：:Glucocorticoids (GC) play a fundamental role in controlling physiologic homeostasis and, when present in excess, can have a detrimental impact on glucose control, blood pressure and lipid levels. The oxidoreductase 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) mainly catalyzes the intracellular regeneration...

journal_title：Current medicinal chemistry

authors： Ge R,Huang Y,Liang G,Li X

更新日期：2010-01-01 00:00:00

abstract：:DNA mutation is a very important step in carcinogenesis and elevated levels of oxidative DNA damage have been monitored in a variety of tumors. The discovery of the role of free radicals in cancer has led to a new medical approach. Minimizing oxidative damage may be a significant advance in the prevention or treatment...

journal_title：Current medicinal chemistry

authors： Tekiner-Gulbas B,Westwell AD,Suzen S

更新日期：2013-01-01 00:00:00

abstract：:COX-2, a key enzyme that catalyzed the rate-limiting steps in the conversion of arachidonic acid to prostaglandins, played a pivotal role in inflammatory process. Different from other family members, COX-2 was barely detectable in normal physiological conditions and highly inducible during acute inflammatory response ...

journal_title：Current medicinal chemistry

authors： Cui J,Jia J

更新日期：2020-09-17 00:00:00

abstract：:More than five decades since the Discovery of Penicillin, the chemistry and biological activity of b-lactams continue to attract the wide spread attention of research workers. Owing to high efficacy and extremely safe toxicological profile, they are agents of choice in the current therapeutic index for the bacterial i...

journal_title：Current medicinal chemistry

authors： Kidwai M,Sapra P,Bhushan KR

更新日期：1999-03-01 00:00:00

abstract：:The immunophilin ligands cyclosporin A, FK506 and rapamycin are best known for their immunosuppressive properties and their clinical use in transplantation medicine. These compounds or their analogs are also clinically used or investigated in various types of cancer, coronary angioplasty, dermatology, hepatitis C infe...

journal_title：Current medicinal chemistry

authors： Gaali S,Gopalakrishnan R,Wang Y,Kozany C,Hausch F

更新日期：2011-01-01 00:00:00

abstract：:Recent advances in endoscopic techniques such as capsule endoscopy have revealed that aspirin and other nonsteroidal antiinflammatory drugs (NSAIDs) often cause mucosal lesions not only in the upper gastrointestinal tract, but also in the small intestine in humans. Gastric and duodenal lesions caused by NSAIDs can be ...

journal_title：Current medicinal chemistry

authors： Satoh H,Takeuchi K

更新日期：2012-01-01 00:00:00

abstract：:Fibroblast growth factor receptor-4 (FGFR4) is a tyrosine kinase with a range of important physiological functions. However, it is also frequently mutated in various cancers and is now generating significant interest as a potential therapeutic target. Unfortunately, biochemical characterization of its role in disease,...

journal_title：Current medicinal chemistry

authors： Ho HK,Németh G,Ng YR,Pang E,Szántai-Kis C,Zsákai L,Breza N,Greff Z,Horváth Z,Pató J,Szabadkai I,Szokol B,Baska F,Őrfî L,Ullrich A,Kéri G,Chua BT

更新日期：2013-01-01 00:00:00

abstract：:Over the past few years, use of the genome-wide association study (GWAS) has made it possible to identify the primary genetic mechanisms of essential hypertension. GWAS results have helped identify many loci in or near genes that generally were not expected to be associated with blood pressure or essential hypertensio...

journal_title：Current medicinal chemistry

authors： Pan S,Naruse H,Nakayama T

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Vaccines are very effective medical tools for disease prevention and life span increase. Controversies have raised concern about their safety, from autism to polio vaccine contamination with simian virus 40 (SV-40). Hysteria surrounding vaccine-associated risks has resulted in a declining number of vaccinati...

journal_title：Current medicinal chemistry

authors： Pandolfi F,Franza L,Todi L,Carusi V,Centrone M,Buonomo A,Chini R,Newton EE,Schiavino D,Nucera E

更新日期：2018-01-01 00:00:00

abstract：:Corticotropin releasing factor (CRF), originally isolated from the mammalian hypothalamus, is a 41 amino acid peptide that plays an important physiological role and is implicated in the pathophysiology of various diseases. In addition to CRF and its related peptides, a large number of small non-peptide CRF analogs hav...

journal_title：Current medicinal chemistry

authors： Liapakis G,Venihaki M,Margioris A,Grigoriadis D,Gkountelias K

更新日期：2011-01-01 00:00:00

abstract：:Apolipoprotein B -containing lipoproteins include triglyceride-rich lipoproteins (chylomicrons and their remnants, and very low-density lipoproteins and their remnants) and cholesterol-rich low-density lipoprotein particles. Of these, lipoproteins having sizes below 70-80 nm may enter the arterial wall, where they acc...

journal_title：Current medicinal chemistry

authors： Öörni K,Lehti S,Sjövall P,Kovanen PT

更新日期：2019-01-01 00:00:00

abstract：:In the course of studying human mucin MUC1, the attitude towards this molecule has been changing time and again. Initially, the list of presumable functions of MUC1 was restricted to protecting and lubricating epithelium. To date, it is assumed to play an important role in cell signaling as well as in all stages of on...

journal_title：Current medicinal chemistry

authors： Syrkina MS,Vassetzky YS,Rubtsov MA

更新日期：2019-01-01 00:00:00