Progress and issues of the genome-wide association study for hypertension.

abstract：:Antibiotics play an irreplaceable role in the prevention and treatment of bacterial infection diseases. However, because of the improper use of antibiotics, bacterial resistance emerges as a major challenge of public health all over the world. The small thiol molecules such as glutathione can directly react and conjug...

journal_title：Current medicinal chemistry

authors： Ouyang Y,Li J,Peng Y,Huang Z,Ren Q,Lu J

更新日期：2020-01-01 00:00:00

abstract：:Xanthones (dibenzo-γ-pyrones) constitutes an important class of oxygenated heterocycles and occur as secondary metabolites in plants and microorganisms. They are known for various biological activities such as antioxidant, monoamine oxidase inhibitor, antihypertensive, hepatoprotective, antithrombotic, antifungal and ...

journal_title：Current medicinal chemistry

authors： Panda SS,Chand M,Sakhuja R,Jain SC

更新日期：2013-01-01 00:00:00

abstract：:Dimerization and oligomerization of G protein-coupled receptors (GPCRs), proposed almost 30 years ago, have crucial relevance for drug design. Indeed, formation of GPCR oligomers may affect the diversity and performance by which extracellular signals are transferred to G proteins in the process of receptor transductio...

journal_title：Current medicinal chemistry

authors： Kaczor AA,Selent J

更新日期：2011-01-01 00:00:00

abstract：:Naturally occurring nonanolides (synonym decanolides) are a large family of secondary metabolites with an interesting 10- membered macrolide subunit. Metabolites of the nonanolide family have been found to have various biological activities, including cytotoxic, phytotoxic, antimalarial, antifungal, antibacterial, and...

journal_title：Current medicinal chemistry

authors： Sun P,Lu S,Ree TV,Krohn K,Li L,Zhang W

更新日期：2012-01-01 00:00:00

abstract：:Bipolar disorder (BD) is a long-term illness with mood swings which are characterized by recurrent episodes of mania/hypomania and depression, with variable interpolations of relatively asymptomatic periods, called euthymic, in which, however, some psychopathological symptoms may persist. Although mood stabilizers, su...

journal_title：Current medicinal chemistry

authors： Musenga A,Saracino MA,Sani G,Raggi MA

更新日期：2009-01-01 00:00:00

abstract：:Neural differentiation of embryonic stem cells (ESC) is considered a promising model to perform in vitro testing for neuroactive and neurotoxic compounds. We studied the potential of a dual reporter murine ESC line to identify bioactive and/or toxic compounds. This line expressed firefly luciferase under the control o...

journal_title：Current medicinal chemistry

authors： Kern I,Xu R,Julien S,Suter DM,Preynat-Seauve O,Baquié M,Poncet A,Combescure C,Stoppini L,Thriel CV,Krause KH

更新日期：2013-01-01 00:00:00

abstract：:The discovery and development of novel drugs has been influenced over the last several decades by new techniques in medicinal chemistry. Combinatorial and parallel synthesis chemistry techniques have opened up immense opportunities in drug discovery and development efforts. These techniques, which include solid phase ...

journal_title：Current medicinal chemistry

authors： Musonda CC,Chibale K

更新日期：2004-10-01 00:00:00

abstract：:The concept of click chemistry represented by the formation of the 1,2,3-triazole core has found wide application in drug discovery, particularly in the early discovery phases and the lead optimization process. 1,2,3-Triazoles ha ve attracted considerable attention in recent years because of their wide range of biolog...

journal_title：Current medicinal chemistry

authors： Raic-Malic S,Mescic A

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Excessive norepinephrine (NE) release in the ischemic heart elicits severe and often lethal arrhythmias. Resident cardiac mast cells synthesize and store active renin, which is released upon degranulation, causing the activation of a local cardiac renin-angiotensin system (RAS) responsible for NE release and...

journal_title：Current medicinal chemistry

authors： Marino A,Levi R

更新日期：2018-01-01 00:00:00

abstract：:Dose-limiting toxicity to healthy tissues is among the major hurdles in anticancer treatment along with intrinsic or acquired multi-drug resistance. Development of small molecule inhibitors (SMI) specific for antiapoptotic Bcl-2 proteins is a novel approach in a way that these antagonists are aimed to interfere with s...

journal_title：Current medicinal chemistry

authors： Bodur C,Basaga H

更新日期：2012-01-01 00:00:00

abstract：:Kit is a growth factor receptor of the type III tyrosine kinase family, whose gain-of-function mutations have been identified as driving causes of different kinds of tumours. It thus represents a viable drug target, and the development of Kit inhibitors has been shown to be a promising therapeutic concept. This review...

journal_title：Current medicinal chemistry

authors： Sartini S,Dario B,Morelli M,Da Settimo F,La Motta C

更新日期：2011-01-01 00:00:00

abstract：:Potent enzyme inhibitors have long been recognized as powerful tools for assessing the physiological roles of enzymes and have led to the therapeutic drugs able to modulate their activities in vivo. However, to be valuable tools such inhibitors should be selective so that they do not interfere with other members of th...

journal_title：Current medicinal chemistry

authors： Batra S,Srinivasan T,Rastogi SK,Kundu B

更新日期：2002-02-01 00:00:00

abstract：:Numerous compounds with a benzothiazole scaffold that have been described in the literature show promising activities against several Gram-positive and Gramnegative bacteria, and also against Mycobacterium tuberculosis. Benzothiazole-based antibacterial compounds bind to different biological targets in bacterial cells...

journal_title：Current medicinal chemistry

authors： Gjorgjieva M,Tomašič T,Kikelj D,Mašič LP

更新日期：2018-01-01 00:00:00

abstract：: ...

journal_title：Current medicinal chemistry

authors： Poplawski T

更新日期：2019-01-01 00:00:00

abstract：:Cancer cells are permanently being selected for survival and proliferation. During this process, tumor cells often co-opt basic physiological mechanisms to protect themselves from toxic chemotherapy. One of these mechanisms is the overexpression of ATP-binding cassette (ABC) drug efflux pumps leading to multidrug resi...

journal_title：Current medicinal chemistry

authors： Lorendeau D,Dury L,Nasr R,Boumendjel A,Teodori E,Gutschow M,Falson P,Di Pietro A,Baubichon-Cortay H

更新日期：2017-01-01 00:00:00

abstract：:Fabry disease (FD) is an X-linked glycosphingolipid storage disorder caused by deficient activity of the lysosomal enzyme alpha-galactosidase A. This leads to a progressive accumulation of globotriaosylceramide (Gb3) in the lysosomes of different cells and tissues, causing principally ventricular hypertrophy, renal fa...

journal_title：Current medicinal chemistry

authors： Caballero L,Climent V,Hernández-Romero D,Quintanilla MA,de la Morena G,Marín F

更新日期：2010-01-01 00:00:00

abstract：: ...

journal_title：Current medicinal chemistry

authors： Mandraffino G,Saitta A

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:We report herein the synthesis of a novel dicationic boron dipyrromethene derivative (compound 3) which is symmetrically substituted with two trimethylammonium styryl groups. METHODS:The antibacterial photodynamic activity of compound 3 was determined against sixteen methicillin-resistant Staphylococcus aur...

journal_title：Current medicinal chemistry

authors： Dharmaratne P,Yu L,Wong RC,Chan BC,Lau KM,Wang B,Lau CB,Fung KP,Ng DK,Ip M

更新日期：2020-12-07 00:00:00

abstract：:The arachidonic acid metabolizing enzymes, cyclooxygenase-2 (COX-2) and 5- lipoxygenase (5-LOX), are both highly expressed during the carcinogenesis in colons. Cigarette smoking promotes these carcinogenic processes at the early stage during adenoma formation. In this article, the involvement of COX-2 and 5-LOX, along...

journal_title：Current medicinal chemistry

authors： Shen J,Li WX,Xiao ZG,Zhang L,Li MX,Li LF,Hu W,Lu L,Boudreau F,Cho CH

更新日期：2016-01-01 00:00:00

abstract：:Specific noncovalent interactions that are indicative of attractive, directional intermolecular forces have always been of key interest to medicinal chemists in their search for the "glue" that holds drugs and their targets together. With the rapid increase in the number of solved biomolecular structures as well as th...

journal_title：Current medicinal chemistry

authors： Zhou P,Huang J,Tian F

更新日期：2012-01-01 00:00:00

abstract：:Chemoprevention is based on the use of non-toxic, pharmacologically active agents to prevent tumor progression. In this regard, natural dietary agents have been described by the most recent literature as promising tools for controlling onset and progression of malignancies. Extensive research has been so far performed...

journal_title：Current medicinal chemistry

authors： Raimondi L,De Luca A,Giavaresi G,Barone A,Tagliaferri P,Tassone P,Amodio N

更新日期：2020-01-01 00:00:00

abstract：:DNA mutation is a very important step in carcinogenesis and elevated levels of oxidative DNA damage have been monitored in a variety of tumors. The discovery of the role of free radicals in cancer has led to a new medical approach. Minimizing oxidative damage may be a significant advance in the prevention or treatment...

journal_title：Current medicinal chemistry

authors： Tekiner-Gulbas B,Westwell AD,Suzen S

更新日期：2013-01-01 00:00:00

abstract：:Mammalian terminal deoxyribonucleotidyl transferase (TDT) catalyzes the non-template-directed polymerization of deoxyribonucleoside triphosphates and has a key role in V(D)J recombination during lymphocyte and repertoire development. Over 90% of leukemic cells in acute lymphocytic leukemia and approximately 30% of leu...

journal_title：Current medicinal chemistry

authors： Di Santo R,Maga G

更新日期：2006-01-01 00:00:00

abstract：:This investigation aims to evaluate strategies for an efficient selection of bioactive compounds from the multitude and biodiversity of the plant kingdom. Statistics prove natural products (NPs) as a source leading most consistently to successful development of new drugs. However, there are several reasons why the int...

journal_title：Current medicinal chemistry

authors： Rollinger JM,Langer T,Stuppner H

更新日期：2006-01-01 00:00:00

abstract：:Factor Xa (fXa) is a critical serine protease situated at the confluence of the intrinsic and extrinsic pathways of the blood coagulation cascade. FXa catalyses the conversion of prothrombin to thrombin via the prothrombinase complex. Its singular role in thrombin generation, coupled with its potentiating effects on c...

journal_title：Current medicinal chemistry

authors： Guertin KR,Choi YM

更新日期：2007-01-01 00:00:00

abstract：:The resin of Pistacia lentiscus (L.) var. chia (Duham), an evergreen shrub belonging to the family Anacardiaceae and uniquely cultivated in southern Chios, is known as mastic. It has been used for more than 2500 years in traditional Greek medicine for treating several diseases such as gastralgia and peptic ulcers, whi...

journal_title：Current medicinal chemistry

authors： Paraschos S,Mitakou S,Skaltsounis AL

更新日期：2012-01-01 00:00:00

abstract：:During this past decade, science and engineering have seen a rapid increase in interest for nanoscale materials with dimensions less than 100 nm, which lie in the intermediate state between atoms and bulk (solid) materials. Their attributes are significantly altered relative to the corresponding bulk materials as they...

journal_title：Current medicinal chemistry

authors： Banerjee R,Katsenovich Y,Lagos L,McIintosh M,Zhang X,Li CZ

更新日期：2010-01-01 00:00:00

abstract：:The therapeutical use of drugs involves the application of dosage forms, serving as carrier systems together with several excipients to deliver the active ingredient to the site of action. Drug delivery technology combines an understanding of medicinal chemistry and pharmacology with the skill of formulation, aiming t...

journal_title：Current medicinal chemistry

authors： Kalász H,Antal I

更新日期：2006-01-01 00:00:00

abstract：:For many years clinicians have been searching for "kidney troponin"- a simple diagnostic tool to assess risk of acute kidney injury (AKI). Recently, the rise in the variety of contrast-related procedures (contrast computed tomography [CT], percutaneous coronary intervention [PCI] and angiography) have resulted in incr...

journal_title：Current medicinal chemistry

authors： Zdziechowska M,Gluba-Brzózka A,Franczyk B,Rysz J

更新日期：2020-05-01 00:00:00

abstract：:Over the years, natural products have shown success as antidiabetics in in vitro, in vivo studies and clinical trials. Because natural product-derived drugs are more affordable and effective with fewer side-effects compared to conventional therapies, pharmaceutical research is increasingly leaning towards the discover...

journal_title：Current medicinal chemistry

authors： Alam F,Islam MA,Kamal MA,Gan SH

更新日期：2018-01-01 00:00:00