Abstract:
:Factor Xa (fXa) is a critical serine protease situated at the confluence of the intrinsic and extrinsic pathways of the blood coagulation cascade. FXa catalyses the conversion of prothrombin to thrombin via the prothrombinase complex. Its singular role in thrombin generation, coupled with its potentiating effects on clot formation render it an attractive target for therapeutic intervention. Otamixaban is a synthetically derived parenteral fXa inhibitor currently in late stage clinical development at Sanofi-Aventis for the management of acute coronary syndrome. Otamixaban is a potent (Ki = 0.5 nM), selective, rapid acting, competitive and reversible fXa inhibitor that effectively inhibits both free and prothrombinase-bound fXa. In vivo experiments have demonstrated that Otamixaban is highly efficacious in rodent, canine and porcine models of thrombosis. In addition, recent clinical findings indicate that Otamixaban is efficacious, safe and well tolerated in humans and therefore has considerable potential for the treatment of acute coronary syndrome. This review article chronicles the discovery and pre-clinical data surrounding the fXa inhibitor Otamixaban as well as the recent clinical findings in humans.
journal_name
Curr Med Chemjournal_title
Current medicinal chemistryauthors
Guertin KR,Choi YMdoi
10.2174/092986707782023659subject
Has Abstractpub_date
2007-01-01 00:00:00pages
2471-81issue
23eissn
0929-8673issn
1875-533Xjournal_volume
14pub_type
杂志文章,评审abstract:: ...
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pub_type: 杂志文章,评审
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更新日期:2019-03-27 00:00:00
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