A Systematic Analysis of Physicochemical and ADME Properties of All Small Molecule Kinase Inhibitors Approved by US FDA from January 2001 to October 2015.

abstract：:The cellular response to DNA damage is critical for determining whether carcinogenesis, cell death or other deleterious biological effects will ensue. Numerous cellular enzymatic mechanisms can directly repair damaged DNA, or allow tolerance of DNA lesions, and thus reduce potential harmful effects. These processes in...

journal_title：Current medicinal chemistry

authors： Lieberman HB

更新日期：2008-01-01 00:00:00

abstract：:Nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) belong to the protein family of neurotrophins. They both display profound neuromodulatory functions and are essentially involved in the survival and homeostatic maintenance of central and peripheral neurons during development and adulthood. Moreove...

journal_title：Current medicinal chemistry

authors： Schulte-Herbrüggen O,Braun A,Rochlitzer S,Jockers-Scherübl MC,Hellweg R

更新日期：2007-01-01 00:00:00

abstract：:In healthy individuals, natural and adaptive immune responses are able to control virus entry into the host. In particular, CD8(+)-mediated cytotoxicity, sustained by the intervention of CD4+ cells, represents the major key event leading to virus eradication. On the other hand, viruses are able to evade from host immu...

journal_title：Current medicinal chemistry

authors： Amati L,Passeri ME,Lippolis A,Lio D,Caruso C,Jirillo E,Covelli V

更新日期：2006-01-01 00:00:00

abstract：:Ten years elapsed since the discovery by Sanofi of SR141716A the first selective CB(1) cannabinoid receptor antagonist. Shortly after, Sanofi also reported the synthesis of the first selective CB(2) cannabinoid receptor antagonist, SR144528. Since these two milestones in the cannabinoid field, many other compounds, mo...

journal_title：Current medicinal chemistry

authors： Muccioli GG,Lambert DM

更新日期：2005-01-01 00:00:00

abstract：OBJECTIVES:Post-exercise cardiac troponin T (cTnT) release has been widely reported in adult athletes but limited data is available for adolescents. The aim of this study was to determine the incidence and magnitude of cTnT appearance in a large group of adolescent runners, and to determine any association between cTnT...

journal_title：Current medicinal chemistry

authors： Nie J,George KP,Tong TK,Gaze D,Tian Y,Lin H,Shi Q

更新日期：2011-01-01 00:00:00

abstract：:N-BP, rapamycin and its derivatives have been originally developed respectively as anti-resorptive and anti-fungal agents. In fact, in vitro and in vivo experiments demonstrated that these compounds are multi-functional molecules exerting their effects on tumour cell growth and bone remodelling. The major challenge in...

journal_title：Current medicinal chemistry

authors： Ory B,Moriceau G,Redini F,Heymann D

更新日期：2007-01-01 00:00:00

abstract：:Many serious inflammatory disorders and nutrient deficiencies induce chronic pain, and anti-inflammatory diets have been applied successfully to modify the inflammatory symptoms causing chronic pain. Numerous scientific data and clinical investigations have demonstrated that long-term inflammation could lead to an ina...

journal_title：Current medicinal chemistry

authors： Bjørklund G,Chirumbolo S,Dadar M,Pen JJ,Doşa MD,Pivina L,Semenova Y,Aaseth J

更新日期：2020-01-01 00:00:00

abstract：:Coeliac disease is a multifactorial disease characterized by a dysregulated immune response to ingested wheat gluten and related cereal proteins. With an incidence of about 1% of the general population, it is considered the most common food intolerance disorder. The mainstay of coeliac disease treatment is strict life...

journal_title：Current medicinal chemistry

authors： Esposito C,Caputo I,Troncone R

更新日期：2007-01-01 00:00:00

abstract：:Mammalian terminal deoxyribonucleotidyl transferase (TDT) catalyzes the non-template-directed polymerization of deoxyribonucleoside triphosphates and has a key role in V(D)J recombination during lymphocyte and repertoire development. Over 90% of leukemic cells in acute lymphocytic leukemia and approximately 30% of leu...

journal_title：Current medicinal chemistry

authors： Di Santo R,Maga G

更新日期：2006-01-01 00:00:00

abstract：:Matrix metalloproteinase-9 (MMP-9) plays an important role in the onset and prognosis of myocardial infarction. Targets of angiotensin converting enzyme (ACE) inhibitors might include not only ACE but also MMP-9, and ACE seems to be closely associated with complications of hypertension such as cardiovascular remodelin...

journal_title：Current medicinal chemistry

authors： Yamamoto D,Takai S

更新日期：2009-01-01 00:00:00

abstract：:This review covers recent literature from 2012-2019 concerning 170 marine natural products and their semisynthetic analogues with strong anticancer biological activities. Reports that shed light on cellular and molecular mechanisms and biological functions of these compounds, thus advancing the understanding in cancer...

journal_title：Current medicinal chemistry

authors： Matulja D,Wittine K,Malatesti N,Laclef S,Turks M,Markovic MK,Ambrožić G,Marković D

更新日期：2020-01-01 00:00:00

abstract：:Aberrant activation of the signal transducer and activator of transcription (STAT) 3 occurs in many human tumors. Constitutive STAT3 activity induces specific target genes that stimulate cell proliferation, prevent apoptosis, promote angiogenesis and facilitate tumor immune evasion. Thus, STAT3 is an attractive molecu...

journal_title：Current medicinal chemistry

authors： Zhao M,Jiang B,Gao FH

更新日期：2011-01-01 00:00:00

abstract：:Fibroblast growth factor receptor-4 (FGFR4) is a tyrosine kinase with a range of important physiological functions. However, it is also frequently mutated in various cancers and is now generating significant interest as a potential therapeutic target. Unfortunately, biochemical characterization of its role in disease,...

journal_title：Current medicinal chemistry

authors： Ho HK,Németh G,Ng YR,Pang E,Szántai-Kis C,Zsákai L,Breza N,Greff Z,Horváth Z,Pató J,Szabadkai I,Szokol B,Baska F,Őrfî L,Ullrich A,Kéri G,Chua BT

更新日期：2013-01-01 00:00:00

abstract：:Sarcopenia, or age-related muscle decline, occurs in most organisms and burdens both human health and the healthcare system. As our population ages, additional options for treating sarcopenia are needed. Mitochondrial dysfunction is implicated in the onset of sarcopenia, so therapies directed at improving mitochondria...

journal_title：Current medicinal chemistry

authors： Waltz TB,Fivenson EM,Morevati M,Li C,Becker KG,Bohr VA,Fang EF

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:Polyphenols are probably the most known and investigated molecules of nutritional interest as micronutrients present in abundance in our diet. Some of the most important food sources of polyphenols in the Mediterranean diet are olives and olive oil. A growing body of evidence from animal models to clinical s...

journal_title：Current medicinal chemistry

authors： Carito V,Ceccanti M,Tarani L,Ferraguti G,Chaldakov GN,Fiore M

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:A great effort has been made to develop efficacious antiviral drugs, but many viral infections are still lack of efficient antiviral therapies so far. The related exploration of natural products to fight viruses has been raised in recent years. Natural compounds with structural diversity and complexity offer...

journal_title：Current medicinal chemistry

authors： Wu YH,Zhang BY,Qiu LP,Guan RF,Ye ZH,Yu XP

更新日期：2017-01-01 00:00:00

abstract：:The hemostatic system comprises platelet aggregation, coagulation and fibrinolysis also termed primary, secondary and tertiary hemostasis. From the platelet transcriptome 6000 mRNA species and represent receptors, ion channels, signalling molecules, kinases, phosphatases, and structural, metabolic and regulatory prote...

journal_title：Current medicinal chemistry

authors： Stassen JM,Arnout J,Deckmyn H

更新日期：2004-09-01 00:00:00

abstract：:Kinetoplastid and apicomplexan parasites comprise a group of protozoans responsible for human diseases, with a serious impact on human health and the socioeconomic growth of developing countries. Chemotherapy is the main option to control these pathogenic organisms and nucleotide metabolism is considered a promising a...

journal_title：Current medicinal chemistry

authors： Valente M,Vidal AE,González-Pacanowska D

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Visible light is absorbed by photoacceptors in pigmented and non-pigmented mammalian cells, activating signaling cascades and downstream mechanisms that lead to the modulation of cellular processes. Most studies have investigated the molecular mechanisms and therapeutic applications of UV and the red to near...

journal_title：Current medicinal chemistry

authors： Garza ZCF,Born M,Hilbers PAJ,van Riel NAW,Liebmann J

更新日期：2018-01-01 00:00:00

abstract：:The stilbene scaffold is a basic element for a number of biologically active natural and synthetic compounds, and it is considered as a privileged structure. Stilbenes exemplified by resveratrol, combretastatin A-4 and pterostilbene are of significant interest for drug research and development because of their potenti...

journal_title：Current medicinal chemistry

authors： Giacomini E,Rupiani S,Guidotti L,Recanatini M,Roberti M

更新日期：2016-01-01 00:00:00

abstract：:COVID-19, a type of infection that emerged in Wuhan, has become a pandemic affecting people worldwide and is rapidly spreading and evolving. Day by day, the confirmed cases and deaths are increasing many folds. SARS-CoV-2 is a novel virus; therefore, limited data are available to curb the disease. Epidemiological appr...

journal_title：Current medicinal chemistry

authors： Kumar R,Harilal S,Al-Sehemi AG,Mathew GE,Carradori S,Mathew B

更新日期：2020-07-02 00:00:00

abstract：:Paclitaxel has been proven to be effective against different types of cancer. A delivery system loaded with paclitaxel at tumor site should provide a high local concentration of the drug detrimental to malignant cells, which prevents the re-growth and metastasis of tumor. In this review, paclitaxel formulations for sy...

journal_title：Current medicinal chemistry

authors： Pawar R,Shikanov A,Vaisman B,Domb AJ

更新日期：2004-02-01 00:00:00

abstract：:Over the last centuries, there were many important discoveries in medicine that were crucial for gaining a better understanding of several physiological processes. Molecular modelling techniques are powerful tools that have been successfully used to analyse and interface medicinal chemistry studies with electrochemica...

journal_title：Current medicinal chemistry

authors： Almeida MO,Maltarollo VG,de Toledo RA,Shim H,Santos MC,Honorio KM

更新日期：2014-01-01 00:00:00

abstract：:Four different types of small RNAs functionally associated with gene silencing have been discovered in animals including small interfering RNAs (siRNAs), microRNAs (miRNAs), and Piwi-interacting RNAs (piRNAs). Experimental evidence suggests that miRNAs regulate the expression of more than 30% of protein-coding genes. ...

journal_title：Current medicinal chemistry

authors： Shah AA,Leidinger P,Blin N,Meese E

更新日期：2010-01-01 00:00:00

abstract：:The existence of functional NT/dopamine interactions in the central nervous system has been extensively documented. Among others, a possible molecular mechanism underlying the NT-induced modulation of dopamine release is a direct antagonistic NTS(1)/D(2) receptor interaction. More recently, neurochemical experiments a...

journal_title：Current medicinal chemistry

authors： Tanganelli S,Antonelli T,Tomasini MC,Beggiato S,Fuxe K,Ferraro L

更新日期：2012-01-01 00:00:00

abstract：:The blood-brain barrier (BBB) impedes the influx of intravascular compounds from the blood to the brain. The elements composing the BBB are endothelial cells, pericytes and the end-feet of astrocytes. Among them, the endothelial cell barrier line is the most critical for preventing toxic substances from entering the b...

journal_title：Current medicinal chemistry

authors： Ueno M

更新日期：2007-01-01 00:00:00

abstract：:Drug repositioning, an innovative therapeutic application of an old drug, has received much attention as a particularly costeffective strategy in drug R&D Recent work has indicated that repositioning can be promoted by utilizing a wide range of information sources, including medicinal chemical, target, mechanism, main...

journal_title：Current medicinal chemistry

authors： Arany Á,Bolgár B,Balogh B,Antal P,Mátyus P

更新日期：2013-01-01 00:00:00

abstract：:Sweat is an alternative biological matrix useful to detect drugs of abuse intake. It is produced by eccrine and apocrine glands originating in the skin dermis and terminating in secretory canals that flow into the skin surface and hair follicles. Since many years it has been demonstrated that endogenous and exogenous ...

journal_title：Current medicinal chemistry

authors： De Giovanni N,Fucci N

更新日期：2013-01-01 00:00:00

abstract：:Nowadays, enzymatic therapy is a very promising line of treatment for many different diseases. There is a group of disorders and conditions, caused by fibrotic and scar processes and associated with the excessive accumulation of collagen that needs to be catabolized to normalize the connective tissue content. The huma...

journal_title：Current medicinal chemistry

authors： Shekhter AB,Balakireva AV,Kuznetsova NV,Vukolova MN,Litvitsky PF,Zamyatnin AA Jr

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Hepatocellular Carcinoma (HCC) is one of the greatest global health burdens because of its uncontrolled cell growth and proliferation, aggressive nature as well as inherited chemoresistance. In spite of different treatment options currently available for HCC, the 5-year relative survival rates for HCC patien...

journal_title：Current medicinal chemistry

authors： Grbčić P,Car EPM,Sedić M

更新日期：2020-01-01 00:00:00