Abstract:
:The existence of functional NT/dopamine interactions in the central nervous system has been extensively documented. Among others, a possible molecular mechanism underlying the NT-induced modulation of dopamine release is a direct antagonistic NTS(1)/D(2) receptor interaction. More recently, neurochemical experiments also supported the existence of a possible interaction between NT and N-methyl-d-aspartate (NMDA) receptors. In particular, it has been suggested that NT, by amplifying NMDA receptor signaling, could be involved in neurodegeneration. The present article attempts to provide a summary of current knowledge, mainly emerging from our studies, on the existence of receptor-receptor interactions between NT receptor subtype 1 (NTS1) and dopamine D(2) or NMDA receptors in the brain. Special emphasis is placed on the pre and post-synaptic neurochemical mechanisms possibly underlying the involvement of these interactions in the physiopathology of schizophrenia and acute neurodegenerative disorders.
journal_name
Curr Med Chemjournal_title
Current medicinal chemistryauthors
Tanganelli S,Antonelli T,Tomasini MC,Beggiato S,Fuxe K,Ferraro Ldoi
10.2174/092986712803414268subject
Has Abstractpub_date
2012-01-01 00:00:00pages
304-16issue
3eissn
0929-8673issn
1875-533Xpii
CMC-19-3-304journal_volume
19pub_type
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