Abstract:
:Glutamate carboxypeptidase II (GCPII) and its splice variants, paralogs and human homologs represent a family of proteins with diverse tissue distribution, cellular localization and largely unknown function which have been explored only recently. While GCPII itself has been thoroughly studied from different perspectives, as clearly documented in this series of reviews, very little is known about other members of its family, even though they might be biologically relevant. Differential expression of individual GCPII splice variants is associated with tumor progression and prognosis of prostate cancer. The best studied GCPII homolog, GCPIII or NAALADase II, may be a valid pharmaceutical target for itself since it may compensate for a lack of normal GCPII enzymatic activity. Detailed molecular characterization of this family of proteins is thus very important not only with respect to the potential therapeutic use of GCPII inhibitors, but also for better understanding of the biological role of GCPII within as well as outside the nervous system.
journal_name
Curr Med Chemjournal_title
Current medicinal chemistryauthors
Hlouchová K,Navrátil V,Tykvart J,Sácha P,Konvalinka Jdoi
10.2174/092986712799462676subject
Has Abstractpub_date
2012-01-01 00:00:00pages
1316-22issue
9eissn
0929-8673issn
1875-533Xpii
CDT-EPUB-20120203-006journal_volume
19pub_type
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