Homocysteine and cerebral ischemia: pathogenic and therapeutical implications.

abstract：:Breakdown of glucose under physiological conditions gives rise to glucose degradation products (GDPs). GDPs are also formed during heat sterilization of glucose-containing peritoneal dialysis fluids (PD-fluids). In PD-fluids GDPs have been shown in many different in vitro assays to be responsible for adverse effects s...

journal_title：Current medicinal chemistry

authors： Ortiz A,Wieslander A,Linden T,Santamaria B,Sanz A,Justo P,Sanchez-Niño MD,Benito A,Kjellstrand P

更新日期：2006-01-01 00:00:00

abstract：:Antimicrobial resistance is an ever-increasing problem throughout the world and has already reached severe proportions. Two very common neglected tropical diseases are Chagas' disease and leishmaniasis. Chagas' disease is a severe health problem, mainly in Latin America, causing approximately 50000 deaths a year and m...

journal_title：Current medicinal chemistry

authors： Bandyopadhyay D,Samano S,Villalobos-Rocha JC,Sanchez-Torres LE,Nogueda-Torres B,Rivera G,Banik BK

更新日期：2017-01-01 00:00:00

abstract：:Natural products from symbiotic or commensal associations between marine invertebrate and microbial organisms show exceptional promise as pharmaceuticals in many therapeutic areas. An economic and sustainable global market supply due to difficulty of synthesis is cited as the main obstacle for exploitation of these ot...

journal_title：Current medicinal chemistry

authors： Dunlap WC,Jaspars M,Hranueli D,Battershill CN,Perić-Concha N,Zucko J,Wright SH,Long PF

更新日期：2006-01-01 00:00:00

abstract：:Antisynthetase syndrome is a group of closely related rare diseases which clinically manifest with inflammatory myopathies, interstitial lung disease, inflammatory arthritis, skin hyperkeratosis (mechanic’s hands) and Raynaud phenomenon. The pathophysiology of antisynthetase syndrome is not entirely understood, but ge...

journal_title：Current medicinal chemistry

authors： Mirrakhimov AE

更新日期：2015-05-13 00:00:00

abstract：:The transport of organic and inorganic molecules, along with inorganic ions across the plasma membrane results in chemical fluxes that reflect the cellular function in healthy and diseased states. Measurement of these chemical fluxes enables the characterization of protein function and transporter stoichiometry, chara...

journal_title：Current medicinal chemistry

authors： Messerli MA,Sarkar A

更新日期：2019-05-06 00:00:00

abstract：:It is well-recognized that the majority of cancer-related deaths is attributed to metastasis, which can arise from virtually any type of tumor. Metastasis is a complex multistep process wherein cancer cells must break away from the primary tumor, intravasate into the circulatory or lymphatic systems, extravasate, prol...

journal_title：Current medicinal chemistry

authors： Wong KM,Song J,Saini V,Wong YH

更新日期：2019-01-01 00:00:00

abstract：:Staphylococcus aureus is a notorious pathogenic bacterium causing a wide range of diseases from soft-tissue contamination, to more serious and deep-seated infections. This species is highlighted by its ability to express several kinds of virulence factors and to acquire genes related to drug resistance. Target this nu...

journal_title：Current medicinal chemistry

authors： Diniz RC,Soares LW,Nascimento da Silva LC

更新日期：2018-01-01 00:00:00

abstract：:Angiogenesis is known to be essential for the development and progression of cancer. Vascular endothelial growth factor (VEGF) is a critical mediator in tumor angiogenesis for many solid malignancies, including breast cancer. Increased levels of VEGF have been associated with poor clinical outcomes, including reduced ...

journal_title：Current medicinal chemistry

authors： Bareschino MA,Schettino C,Colantuoni G,Rossi E,Rossi A,Maione P,Ciardiello F,Gridelli C

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:Chronic Liver Disorders (CLD), caused by the lifestyle patterns like alcoholism or by non-alcoholic fatty liver disease or because of virus-mediated hepatitis, affect a large population fraction across the world. CLD progresses into end-stage diseases with a high mortality rate. Liver transplant is the only ...

journal_title：Current medicinal chemistry

authors： Mahmood A,Seetharaman R,Kshatriya P,Patel D,Srivastava AS

更新日期：2020-01-01 00:00:00

abstract：:Schizophrenia is a chronic psychiatric disorder that affects about 1 in 100 people around the world and results in persistent emotional and cognitive impairments. Untreated schizophrenia leads to deterioration in quality of life and premature death. Although the clinical efficacy of dopamine D2 receptor antagonists ag...

journal_title：Current medicinal chemistry

authors： Jankowska A,Satała G,Partyka A,Wesołowska A,Bojarski AJ,Pawłowski M,Chłoń-Rzepa G

更新日期：2019-01-01 00:00:00

abstract：:Matrix metalloproteinases (MMPs) are essential for the degradation and turnover of components of the extracellular matrix (ECM) and, when pathologically elevated, mediate connective tissue loss (including bone destruction) in various inflammatory and other diseases. Tetracyclines (TCs) are known inhibitors of mammalia...

journal_title：Current medicinal chemistry

authors： Zhang Y,Gu Y,Lee HM,Hambardjieva E,Vranková K,Golub LM,Johnson F

更新日期：2012-01-01 00:00:00

abstract：:Nutritional iron deficiency represents a relevant health problem mainly in developing countries. Children and pregnant women represent the main target of this disease, and the low amount of bio-available iron mostly depends on plant-based diets. Iron deficiency may have serious consequences, with severe impairment of ...

journal_title：Current medicinal chemistry

authors： Lachowicz JI,Nurchi VM,Fanni D,Gerosa C,Peana M,Zoroddu MA

更新日期：2014-01-01 00:00:00

abstract：:Genito-urinary malignancies (prostate, bladder, renal and testicular cancers) rank high among human tumors with an incidence that varies with age and organ involvement. Prostate cancer is the most commonly detected male cancer followed by bladder and kidney cancers, less frequent in women. Testicular cancer, although ...

journal_title：Current medicinal chemistry

authors： Cantile M,Franco R,Schiavo G,Procino A,Cindolo L,Botti G,Cillo C

更新日期：2011-01-01 00:00:00

abstract：: ...

journal_title：Current medicinal chemistry

authors： Biava PM,Nicolini A

更新日期：2019-01-01 00:00:00

abstract：:Naturally occurring nonanolides (synonym decanolides) are a large family of secondary metabolites with an interesting 10- membered macrolide subunit. Metabolites of the nonanolide family have been found to have various biological activities, including cytotoxic, phytotoxic, antimalarial, antifungal, antibacterial, and...

journal_title：Current medicinal chemistry

authors： Sun P,Lu S,Ree TV,Krohn K,Li L,Zhang W

更新日期：2012-01-01 00:00:00

abstract：:Combination therapy in the treatment of viral infections in which, for example, three different drugs against three different targets on three independent proteins are administered, has been highly successful clinically. However, it is only a matter of time before a virus will arise resistant to all three drugs, becau...

journal_title：Current medicinal chemistry

authors： Mangel WF,McGrath WJ,Brown MT,Baniecki ML,Barnard DL,Pang YP

更新日期：2001-07-01 00:00:00

abstract：BACKGROUND:The sterile alpha motif (Sam) domain is a small helical protein module, able to undergo homo- and hetero-oligomerization, as well as polymerization, thus forming different types of protein architectures. A few Sam domains are involved in pathological processes and consequently, they represent valuable target...

journal_title：Current medicinal chemistry

authors： Vincenzi M,Mercurio FA,Leone M

更新日期：2020-01-01 00:00:00

abstract：:Osteogenic peptides are, or have potential to be, therapies for the treatment of osteoporosis, fracture repair, and repair of loosened bone implants. Human parathyroid hormone has been approved for the treatment of post-menopausal osteoporosis. Constrained analogs of PTH and the parathyroid-hormone related peptide (PT...

journal_title：Current medicinal chemistry

authors： Willick GE,Morley P,Whitfield JF

更新日期：2004-11-01 00:00:00

abstract：:Coeliac disease is a multifactorial disease characterized by a dysregulated immune response to ingested wheat gluten and related cereal proteins. With an incidence of about 1% of the general population, it is considered the most common food intolerance disorder. The mainstay of coeliac disease treatment is strict life...

journal_title：Current medicinal chemistry

authors： Esposito C,Caputo I,Troncone R

更新日期：2007-01-01 00:00:00

abstract：:The biological relevance of sulfur containing carbohydrates is gaining substantial attention. Thus the new developments, especially in the synthetic and medicinal chemistry of thio-sugars are critically important for carbohydrate drug design. New studies of biological processes including biosynthetic reactions and enz...

journal_title：Current medicinal chemistry

authors： Witczak ZJ

更新日期：1999-02-01 00:00:00

abstract：:Dimerization and oligomerization of G protein-coupled receptors (GPCRs), proposed almost 30 years ago, have crucial relevance for drug design. Indeed, formation of GPCR oligomers may affect the diversity and performance by which extracellular signals are transferred to G proteins in the process of receptor transductio...

journal_title：Current medicinal chemistry

authors： Kaczor AA,Selent J

更新日期：2011-01-01 00:00:00

abstract：:Although the renin-angiotensin system (RAS) is already an old acquaintance, there are often exciting discoveries that improve our knowledge of it and open new therapeutic possibilities. Moreover, well-established drugs, such as angiotensin-converting enzyme inhibitors (ACEI), angiotensin receptor blockers (ARB), or be...

journal_title：Current medicinal chemistry

authors： Ramírez-Sánchez M,Prieto I,Wangensteen R,Banegas I,Segarra AB,Villarejo AB,Vives F,Cobo J,de Gasparo M

更新日期：2013-01-01 00:00:00

abstract：:Nowadays, fast and sensitive methods for biomarkers detection exist, but the performance of most of them still rely centralized laboratory testing. The development of small, fast and simple to use medical devices that can help in making diagnosis accurate and with low-invasiveness is now a major challenge for nanotech...

journal_title：Current medicinal chemistry

authors： Bedin C,Crotti S,Tasciotti E,Agostini M

更新日期：2018-01-01 00:00:00

abstract：:Lipoxygenases (LOXs) are non-heme iron containing dioxygenases involved in the oxygenation of polyunsaturated fatty acids (PUFAs) such as arachidonic acid (AA). Depending on the position of insertion of oxygen, LOXs are classified into 5-, 8-, 9-, 12- and 15-LOX. Among these, 5-LOX is the most predominant isoform asso...

journal_title：Current medicinal chemistry

authors： Aparoy P,Reddy KK,Reddanna P

更新日期：2012-01-01 00:00:00

abstract：:Xanthones (dibenzo-γ-pyrones) constitutes an important class of oxygenated heterocycles and occur as secondary metabolites in plants and microorganisms. They are known for various biological activities such as antioxidant, monoamine oxidase inhibitor, antihypertensive, hepatoprotective, antithrombotic, antifungal and ...

journal_title：Current medicinal chemistry

authors： Panda SS,Chand M,Sakhuja R,Jain SC

更新日期：2013-01-01 00:00:00

abstract：:Atrial fibrillation is the most common disorder of cardiac rhythm. In spite of diagnosis simplicity, patients with atrial fibrillation are difficult to treat. In the recent years with the description of the phenomenon called remodelling, it has been possible to better define the principle mechanisms responsible for in...

journal_title：Current medicinal chemistry

authors： Lombardi F,Terranova P

更新日期：2005-01-01 00:00:00

abstract：:Glycosaminoglycans, highly charged polycarboxylated, polysulfated polysaccharides, are an important class of therapeutic agents and investigational drug candidates. Heparin has been widely used as a clinical anticoagulant for over 60 years. Low molecular weight heparins have begun to displace heparin and recently a sy...

journal_title：Current medicinal chemistry

authors： Karst NA,Linhardt RJ

更新日期：2003-10-01 00:00:00

abstract：:The present paper summarizes the possible roles of frequent and unfavourable genetic variants in cerebrovascular disorders, such as stroke and leukoaraiosis. It also approaches the topic theoretically from functional and mathematical points of view, which can help make the accumulating data on genetic variants more un...

journal_title：Current medicinal chemistry

authors： Szolnoki Z

更新日期：2009-01-01 00:00:00

abstract：:Over the years, natural products have shown success as antidiabetics in in vitro, in vivo studies and clinical trials. Because natural product-derived drugs are more affordable and effective with fewer side-effects compared to conventional therapies, pharmaceutical research is increasingly leaning towards the discover...

journal_title：Current medicinal chemistry

authors： Alam F,Islam MA,Kamal MA,Gan SH

更新日期：2018-01-01 00:00:00

abstract：:Epigenetics is a field of biological sciences focused on the study of reversible, heritable changes in gene function not due to modifications of the genomic sequence. These changes are the result of a complex cross-talk between several molecular mechanisms, that is in turn orchestrated by genetic and environmental fac...

journal_title：Current medicinal chemistry

authors： De Riso G,Cocozza S

更新日期：2020-11-17 00:00:00