Abstract：
:Genito-urinary malignancies (prostate, bladder, renal and testicular cancers) rank high among human tumors with an incidence that varies with age and organ involvement. Prostate cancer is the most commonly detected male cancer followed by bladder and kidney cancers, less frequent in women. Testicular cancer, although rare, is the most frequent cancer in males under 35. The majority of oncogenic and tumor suppressor signaling pathways involved with urogenital cancers converge on sets of transcription factors that ultimately control gene expression resulting in tumor formation and metastatic progression. The activity of these transcription factors is modulated by multiple mechanisms spanning from transcriptional regulation, deregulation of the splicing, maturation, export and location of mRNAs, protein synthesis and post-translational modifications. The recent involvement of the epigenitic mechanisms in the generation and the evolution of cancer has produced a great deal of interest. This is related to the possibility that revealing these mechanisms able to regulate the cell memory program (the gene systems polycomb, trithorax and HOX) may generate important biological and therapeutic achievements. The HOX gene network is the only physically and functionally identifiable transcription factor network located in the human genome controlling crucial cellular processes. Here we describe the implication of the HOX genes in the urogenital embryonic development and cancers. We further highlight the mechanisms uncovered along these processes and involving the HOX genes. Finally, we foresee the specific targeting of HOX genes and in general the cell memory gene program in the therapeutic setting of urogenital malignancies due to their upstream location in these stepwise cell processes and their early deregulation in cancer evolution.
journal_name
Curr Med Chemjournal_title
Current medicinal chemistryauthors
Cantile M,Franco R,Schiavo G,Procino A,Cindolo L,Botti G,Cillo Cdoi
10.2174/092986711797535182subject
Has Abstractpub_date
2011-01-01 00:00:00pages
4872-84issue
32eissn
0929-8673issn
1875-533Xpii
BSP/CMC/E-Pub/2011/361journal_volume
18pub_type
杂志文章,评审abstract：:Osteoporosis is characterized by reduced bone mass and structural deterioration of bone tissue leading to enhanced bone fragility and a consequent increase in fracture risk. Bone loss further increases in postmenopausal women when the ovaries stop making estrogens. Women undergoing treatment for osteoporosis require l...
journal_title：Current medicinal chemistry
pub_type： 杂志文章,评审
doi：10.2174/092986710791959738
更新日期：2010-01-01 00:00:00
abstract：:Ornithine transcarbamylase (OTC; EC 2.1.3.3) is a one-carbon-unit transferring enzyme that synthesizes citrulline using ornithine and carbamoylphosphate as substrates. It is involved in the metabolic transformation of arginine and proline, and it participates in the urea cycle in vertebrates and in the formation of pu...
journal_title：Current medicinal chemistry
pub_type： 杂志文章,评审
doi：10.2174/092986710791331031
更新日期：2010-01-01 00:00:00
abstract：:This review summarizes our knowledge of biochemical, biological and medical applications and properties of phosphinic acid compounds. Phosphinic acid compounds (phosphinates) are derivatives of phosphinic acid H2P(O)(OH). The major attention of this article is focused on applications of phosphinates of a pseudopeptide...
journal_title：Current medicinal chemistry
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doi：10.2174/0929867003374831
更新日期：2000-06-01 00:00:00
abstract：:Protein-ligand docking is currently an important tool in drug discovery efforts and an active area of research that has been the subject of important developments over the last decade. These are well portrayed in the rising number of available protein-ligand docking software programs, increasing level of sophisticatio...
journal_title：Current medicinal chemistry
pub_type： 历史文章,杂志文章,评审
doi：10.2174/0929867311320180002
更新日期：2013-01-01 00:00:00
abstract：:Recent work on a number of different classes of anticancer agents that alkylate DNA in the minor groove is reviewed. There has been much work with nitrogen mustards, where attachment of the mustard unit to carrier molecules can change the normal patterns of both regio- and sequence-selectivity, from reaction primarily...
journal_title：Current medicinal chemistry
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更新日期：2001-04-01 00:00:00
abstract：:Currently, the long-term usage of non-nucleoside reverse transcriptase inhibitors (NNRTIs) in HIVAIDS patients eventually leads to the development of drug resistance and severe side effect. Therefore, it is imperative to look for the novel NNRTIs with potent and broad spectrum anti-mutant activity that are also safe a...
journal_title：Current medicinal chemistry
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更新日期：2009-01-01 00:00:00
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journal_title：Current medicinal chemistry
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更新日期：2021-01-06 00:00:00
abstract：BACKGROUND:In the last two decades, there have been significant technological advances in the early detection of brain tumors. However, no notable improvements have been observed in the treatment of Glioblastoma Multiforme (GBM), the most common brain neoplasm coupled with the worst prognosis. GBM is characterized by a...
journal_title：Current medicinal chemistry
pub_type： 杂志文章,评审
doi：10.2174/0929867324666170303122241
更新日期：2017-01-01 00:00:00
abstract：:DNA mutation is a very important step in carcinogenesis and elevated levels of oxidative DNA damage have been monitored in a variety of tumors. The discovery of the role of free radicals in cancer has led to a new medical approach. Minimizing oxidative damage may be a significant advance in the prevention or treatment...
journal_title：Current medicinal chemistry
pub_type： 杂志文章,评审
doi：10.2174/09298673113203690142
更新日期：2013-01-01 00:00:00
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journal_title：Current medicinal chemistry
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更新日期：2011-01-01 00:00:00
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journal_title：Current medicinal chemistry
pub_type： 杂志文章,评审
doi：10.2174/0929867324666170830102409
更新日期：2019-01-01 00:00:00
abstract：:Semicarbazide-sensitive amine-oxidase (SSAO) is present in various human tissues and in plasma. Oxidative deamination of short-chain aliphatic amines is catalyzed by this enzyme to afford the corresponding aldehydes, ammonia and hydrogen peroxide. Methylamine and aminoacetone have been recognized to be physiological s...
journal_title：Current medicinal chemistry
pub_type： 杂志文章,评审
doi：10.2174/0929867043365305
更新日期：2004-05-01 00:00:00
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journal_title：Current medicinal chemistry
pub_type： 杂志文章,评审
doi：10.2174/0929867033457944
更新日期：2003-04-01 00:00:00
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journal_title：Current medicinal chemistry
pub_type： 杂志文章,评审
doi：10.2174/0929867326666191212162102
更新日期：2020-01-01 00:00:00
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journal_title：Current medicinal chemistry
pub_type： 杂志文章,评审
doi：10.2174/092986708785132924
更新日期：2008-01-01 00:00:00
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journal_title：Current medicinal chemistry
pub_type： 杂志文章,评审
doi：10.2174/0929867324666170609080000
更新日期：2018-01-01 00:00:00
abstract：:Nitric oxide (NO) has been established as an important messenger molecule in various steps of brain physiology, from development to synaptic plasticity, learning and memory. However, NO has also been viewed as a major agent of neuropathology when, escaping controlled production it may directly or indirectly promote ox...
journal_title：Current medicinal chemistry
pub_type： 杂志文章,评审
doi：10.2174/0929867033456792
更新日期：2003-10-01 00:00:00
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journal_title：Current medicinal chemistry
pub_type： 杂志文章,评审
doi：10.2174/0929867003374183
更新日期：2000-12-01 00:00:00
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journal_title：Current medicinal chemistry
pub_type： 杂志文章
doi：10.2174/09298673113206660289
更新日期：2014-03-01 00:00:00
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journal_title：Current medicinal chemistry
pub_type： 杂志文章,评审
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更新日期：2011-01-01 00:00:00
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journal_title：Current medicinal chemistry
pub_type： 杂志文章,评审
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更新日期：2005-01-01 00:00:00
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journal_title：Current medicinal chemistry
pub_type： 杂志文章,评审
doi：
更新日期：1999-08-01 00:00:00
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journal_title：Current medicinal chemistry
pub_type： 杂志文章,评审
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更新日期：2019-01-01 00:00:00
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journal_title：Current medicinal chemistry
pub_type： 杂志文章,评审
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更新日期：2012-01-01 00:00:00
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journal_title：Current medicinal chemistry
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更新日期：1998-10-01 00:00:00
abstract：:Kinetoplastid and apicomplexan parasites comprise a group of protozoans responsible for human diseases, with a serious impact on human health and the socioeconomic growth of developing countries. Chemotherapy is the main option to control these pathogenic organisms and nucleotide metabolism is considered a promising a...
journal_title：Current medicinal chemistry
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更新日期：2019-01-01 00:00:00
abstract：:Antisynthetase syndrome is a group of closely related rare diseases which clinically manifest with inflammatory myopathies, interstitial lung disease, inflammatory arthritis, skin hyperkeratosis (mechanic’s hands) and Raynaud phenomenon. The pathophysiology of antisynthetase syndrome is not entirely understood, but ge...
journal_title：Current medicinal chemistry
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更新日期：2015-05-13 00:00:00
abstract：BACKGROUND:A great effort has been made to develop efficacious antiviral drugs, but many viral infections are still lack of efficient antiviral therapies so far. The related exploration of natural products to fight viruses has been raised in recent years. Natural compounds with structural diversity and complexity offer...
journal_title：Current medicinal chemistry
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更新日期：2017-01-01 00:00:00
abstract：:Sweat is an alternative biological matrix useful to detect drugs of abuse intake. It is produced by eccrine and apocrine glands originating in the skin dermis and terminating in secretory canals that flow into the skin surface and hair follicles. Since many years it has been demonstrated that endogenous and exogenous ...
journal_title：Current medicinal chemistry
pub_type： 杂志文章,评审
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更新日期：2013-01-01 00:00:00
abstract：:Xanthones (dibenzo-γ-pyrones) constitutes an important class of oxygenated heterocycles and occur as secondary metabolites in plants and microorganisms. They are known for various biological activities such as antioxidant, monoamine oxidase inhibitor, antihypertensive, hepatoprotective, antithrombotic, antifungal and ...
journal_title：Current medicinal chemistry
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更新日期：2013-01-01 00:00:00
