Abstract:
:Over the years, natural products have shown success as antidiabetics in in vitro, in vivo studies and clinical trials. Because natural product-derived drugs are more affordable and effective with fewer side-effects compared to conventional therapies, pharmaceutical research is increasingly leaning towards the discovery of new antidiabetic drugs from natural products targeting pathways or components associated with type 2 diabetes mellitus (T2DM) pathophysiology. However, the drug discovery process is very lengthy and costly with significant challenges. Therefore, various techniques are currently being developed for the preclinical research phase of drug discovery with the aim of drug development with less time and efforts from natural products. In this review, we have provided an update on natural products including fruits, vegetables, spices, nuts, beverages and mushrooms with potential antidiabetic activities from in vivo, in vitro and clinical studies. Synergistic interactions between natural products and antidiabetic drugs, and potential antidiabetic active compounds from natural products are also documented to pave the way for combination treatment and new drug discovery, respectively. Additionally, a brief idea of the drug discovery process along with the challenges that arise during drug development from natural products and the methods to conquer those challenges are discussed to create a more convenient future drug discovery process.
journal_name
Curr Med Chemjournal_title
Current medicinal chemistryauthors
Alam F,Islam MA,Kamal MA,Gan SHdoi
10.2174/0929867323666160813222436subject
Has Abstractpub_date
2018-01-01 00:00:00pages
5395-5431issue
39eissn
0929-8673issn
1875-533Xpii
CMC-EPUB-77752journal_volume
25pub_type
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journal_title:Current medicinal chemistry
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更新日期:2014-01-01 00:00:00
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journal_title:Current medicinal chemistry
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更新日期:2012-01-01 00:00:00
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journal_title:Current medicinal chemistry
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更新日期:2008-01-01 00:00:00
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更新日期:2007-01-01 00:00:00
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更新日期:2002-07-01 00:00:00
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journal_title:Current medicinal chemistry
pub_type: 杂志文章,评审
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更新日期:2003-04-01 00:00:00
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更新日期:2012-01-01 00:00:00
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journal_title:Current medicinal chemistry
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更新日期:2011-01-01 00:00:00
abstract::TB drug development pipeline represents varied structural classes of molecules. Oxazolidinones represent synthetic anti-bacterial agents with unique mechanism of action having wide spectrum of activity, oral bioavailability and well established SAR. They act by inhibiting translation at the initiation phase of protein...
journal_title:Current medicinal chemistry
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更新日期:2015-01-01 00:00:00
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更新日期:2004-04-01 00:00:00
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更新日期:2016-01-01 00:00:00
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abstract::Rubus species (family Rosaceae) have been cultivated for centuries for their fruits. These and other parts of the plants have been used traditionally for therapeutic purposes. This article highlights these and the potential they can offer. The constituents reported in the various species and those demonstrated to exhi...
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更新日期:2004-06-01 00:00:00
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更新日期:2009-01-01 00:00:00
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更新日期:2016-01-01 00:00:00