Abstract:
:Thymosin Beta-4 (Tβ4) is known as a major pleiotropic actin-sequestering protein that is involved in tumorigenesis. Tβ4 is a water-soluble protein that has different promising clinical applications in the remodeling and ulcerated tissues repair following myocardial infarction, stroke, plasticity and neurovascular remodeling of the Peripheral Nervous System (PNS) and the Central Nervous System (CNS). On the other hand, similar effects have been observed for Tβ4 in other kinds of tissues, including cardiac muscle tissue. In recent reports, as it activates resident epicardial progenitor cells and modulates inflammatory-caused injuries, Tβ4 has been suggested as a promoter of the survival of cardiomyocytes. Furthermore, Tβ4 may act in skeletal muscle and different organs in association/synergism with numerous other tissue repair stimulating factors, including melatonin and C-fiber-derived peptides. For these reasons, the present review highlights the promising role of Tβ4 in cardiac healing.
journal_name
Curr Med Chemjournal_title
Current medicinal chemistryauthors
Bjørklund G,Dadar M,Aaseth J,Chirumbolo Sdoi
10.2174/0929867326666190716125456subject
Has Abstractpub_date
2020-01-01 00:00:00pages
6294-6305issue
37eissn
0929-8673issn
1875-533Xpii
CMC-EPUB-99680journal_volume
27pub_type
杂志文章,评审abstract:: ...
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