Abstract:
:Marine organisms are abundant sources of bioactive natural products. Among metabolites produced by sponges and their associated microbial communities, halogenated natural compounds accounted for an important part due to their potent biological activities. The present review updates and compiles a total of 258 halogenated organic compounds isolated in the past three decades, especially brominated derivatives derived from 31 genera of marine sponges. These compounds can be classified as the following classes: brominated polyunsaturated lipids, nitrogen compounds, brominated tyrosine derivatives and other halogenated compounds. These substances were listed together with their source organisms, structures and bioactivities. For this purpose, 84 references were consulted.
journal_name
Curr Med Chemjournal_title
Current medicinal chemistryauthors
Li C,Shi Ddoi
10.2174/0929867325666181112092159subject
Has Abstractpub_date
2020-01-01 00:00:00pages
2335-2360issue
14eissn
0929-8673issn
1875-533Xpii
CMC-EPUB-94418journal_volume
27pub_type
杂志文章,评审abstract::The purinergic receptor P2X7 is highly expressed in immune peripheral and central cells suggesting its important role in numerous diseases characterized by inflammatory processes like cancer, or neurodegenerative pathologies in relation with modulation of the immune system. Thereby, antagonization of this receptor may...
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journal_title:Current medicinal chemistry
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