Abstract:
:There is a need for novel drugs for the treatment of infectious diseases, autoimmunity and cancer. Cyclic peptides constitute a class of compounds that have made crucial contributions to the treatment of certain diseases. Penicillin, Vancomycin, Cyclosporin, the Echinocandins and Bleomycin are well-known cyclic peptides. Cyclic peptides, compared to linear peptides, have been considered to have greater potential as therapeutic agents due to their increased chemical and enzymatic stability, receptor selectively, and improved pharmacodynamic properties. They have been used as synthetic immunogens, transmembrane ion channels, antigens for Herpes Simplex Virus, potential immunotherapeutic vaccines for diabetes and Experimental Autoimmune Encephalomyelitis - an animal model of Multiple Sclerosis, as inhibitors against alpha-amylase and as protein stabilizers. Herein, we review important cyclic peptides as therapeutic agents in disease.
journal_name
Curr Med Chemjournal_title
Current medicinal chemistryauthors
Katsara M,Tselios T,Deraos S,Deraos G,Matsoukas MT,Lazoura E,Matsoukas J,Apostolopoulos Vdoi
10.2174/092986706777935113subject
Has Abstractpub_date
2006-01-01 00:00:00pages
2221-32issue
19eissn
0929-8673issn
1875-533Xjournal_volume
13pub_type
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journal_title:Current medicinal chemistry
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journal_title:Current medicinal chemistry
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journal_title:Current medicinal chemistry
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journal_title:Current medicinal chemistry
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journal_title:Current medicinal chemistry
pub_type: 杂志文章,评审
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更新日期:2005-01-01 00:00:00
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journal_title:Current medicinal chemistry
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更新日期:2006-01-01 00:00:00
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更新日期:2017-01-01 00:00:00
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更新日期:2019-01-01 00:00:00
abstract::Breast cancer arises in about 48% of patients older than 65 years and more than 30% occurs in those over 70 years being the leading cause of cancer-related death in women older than 65. Elderly patients tolerate chemotherapy poorly compared to their younger counterpart because of progressive reduction of organ functio...
journal_title:Current medicinal chemistry
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更新日期:2005-01-01 00:00:00
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journal_title:Current medicinal chemistry
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更新日期:2001-12-01 00:00:00
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journal_title:Current medicinal chemistry
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更新日期:2005-01-01 00:00:00
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更新日期:2018-01-01 00:00:00
abstract::Fullerenes as a unique class of carbon allotropes have been studied extensively for their distinctive material properties and potential technological applications, including those in biology and medicine. Since a major focus in the latter has been on drug development and formulation, in this paper we highlight some re...
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更新日期:2011-01-01 00:00:00
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更新日期:2014-01-01 00:00:00
abstract::It is well-recognized that the majority of cancer-related deaths is attributed to metastasis, which can arise from virtually any type of tumor. Metastasis is a complex multistep process wherein cancer cells must break away from the primary tumor, intravasate into the circulatory or lymphatic systems, extravasate, prol...
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更新日期:2019-01-01 00:00:00
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更新日期:2007-01-01 00:00:00
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更新日期:2005-01-01 00:00:00
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更新日期:2016-01-01 00:00:00
abstract::CBP and p300 are two closely related Histone Acetyltransferases (HATs) that interact with numerous transcription factors and act to increase the expression of their target genes. Both proteins contain a bromodomain flanking the HAT catalytic domain that is important in binding of CBP/p300 to chromatin, which offers an...
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更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:During lead identification and optimization, the advancement criteria may be driven based on scientific principles, prior experiences, and/or by examining the path paved by approved drugs. However, accessing the discovery data on physicochemical and ADME properties of the approved kinase inhibitors is a monu...
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更新日期:2017-01-01 00:00:00
abstract::Chagas disease is one of the most important endemic diseases in Latin America, caused by Trypanosoma cruzi. The drugs used for the treatment of this disease, nifurtimox and benznidazole, are toxic and present severe side effects. The need of effective drugs, without adverse effects, has stimulated the search for new c...
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更新日期:2011-01-01 00:00:00
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更新日期:2014-01-01 00:00:00
abstract::The serine protease thrombin is a key enzyme in the control of blood coagulation and displays numerous other effects on platelet, endothelial and smooth muscle cell function. The pre-eminence of thrombin in the coagulation cascade has made the enzyme a popular drug target in the search for more clinically acceptable a...
journal_title:Current medicinal chemistry
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更新日期:1998-12-01 00:00:00
abstract::Trypanosomatids are a group of flagellated unicellular eukaryotes, causing serious human diseases including Chagas disease (Trypanosoma cruzi), sleeping sickness (Trypanosoma brucei spp.) and Leishmaniasis (Leishmania spp.). The second messenger cAMP is involved in numerous and fundamental processes in these parasites...
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更新日期:2019-01-01 00:00:00
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更新日期:2011-01-01 00:00:00
abstract::Nutritional iron deficiency represents a relevant health problem mainly in developing countries. Children and pregnant women represent the main target of this disease, and the low amount of bio-available iron mostly depends on plant-based diets. Iron deficiency may have serious consequences, with severe impairment of ...
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更新日期:2014-01-01 00:00:00