Abstract:
:The purinergic receptor P2X7 is highly expressed in immune peripheral and central cells suggesting its important role in numerous diseases characterized by inflammatory processes like cancer, or neurodegenerative pathologies in relation with modulation of the immune system. Thereby, antagonization of this receptor may be a hopeful therapeutic strategy to treat a large range of diseases. Indeed, selective P2X7 antagonists display beneficial anti-inflammatory, analgesic, and in some cases, anticancer properties. This article will review the involvement of P2X7 in the immune system, the update of P2X7 antagonists series since 2009 and their promising therapeutic potential for the treatment of several immune- related diseases.
journal_name
Curr Med Chemjournal_title
Current medicinal chemistryauthors
Baudelet D,Lipka E,Millet R,Ghinet Adoi
10.2174/0929867322666141212120926subject
Has Abstractpub_date
2015-01-01 00:00:00pages
713-29issue
6eissn
0929-8673issn
1875-533Xpii
CMC-EPUB-63956journal_volume
22pub_type
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journal_title:Current medicinal chemistry
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