Can breast cancer stem cells evade the immune system?

abstract：:Borderline Personality Disorder (BPD) is a common disorder in psychiatric practice and drugs are widely used in its treatment, targeting symptom clusters, such as affective dysregulation, impulsive-behavioural dyscontrol, and cognitive-perceptual symptoms. In last period, a growing number of studies on pharmacological...

journal_title：Current medicinal chemistry

authors： Bellino S,Rinaldi C,Bozzatello P,Bogetto F

更新日期：2011-01-01 00:00:00

abstract：:Stress or heat shock proteins (Hsps) Hsp90, Hsp70 and Hsp27 are chaperones that assist the proteins in their folding, stability, assembly into multi-protein complexes and transport across cellular membranes. The expression of some of them is highly induced in response to a wide variety of physiological and environment...

journal_title：Current medicinal chemistry

authors： Didelot C,Lanneau D,Brunet M,Joly AL,De Thonel A,Chiosis G,Garrido C

更新日期：2007-01-01 00:00:00

abstract：:Cervical spondylotic myelopathy (CSM) is a very common and debilitating disease; however, its underlying pathocellular process remains uncertain. Attempts have been made to reproduce CSM in experimental animal models in order to deepen the knowledge on the molecular pathobiology of this disease. The up-to-date observa...

journal_title：Current medicinal chemistry

authors： Karadimas SK,Gialeli CH,Klironomos G,Tzanakakis GN,Panagiotopoulos E,Karamanos NK,Gatzounis G

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND:Vaccines are very effective medical tools for disease prevention and life span increase. Controversies have raised concern about their safety, from autism to polio vaccine contamination with simian virus 40 (SV-40). Hysteria surrounding vaccine-associated risks has resulted in a declining number of vaccinati...

journal_title：Current medicinal chemistry

authors： Pandolfi F,Franza L,Todi L,Carusi V,Centrone M,Buonomo A,Chini R,Newton EE,Schiavino D,Nucera E

更新日期：2018-01-01 00:00:00

abstract：:Many of the currently available treatments for obsessive-compulsive and related disorders (OCRDs) such as pharmacotherapy augmentation strategies, partial hospitalization programs, deep brain stimulation, and neurosurgery are efficacious for individuals suffering from more severe forms of these conditions. Unfortunate...

journal_title：Current medicinal chemistry

authors： Fontenelle LF,Zeni-Graiff M,Quintas JN,Yücel M

更新日期：2018-01-01 00:00:00

abstract：:Osteoporosis is characterized by reduced bone mass and structural deterioration of bone tissue leading to enhanced bone fragility and a consequent increase in fracture risk. Bone loss further increases in postmenopausal women when the ovaries stop making estrogens. Women undergoing treatment for osteoporosis require l...

journal_title：Current medicinal chemistry

authors： Bitto A,Polito F,Squadrito F,Marini H,D'Anna R,Irrera N,Minutoli L,Granese R,Altavilla D

更新日期：2010-01-01 00:00:00

abstract：:The development of biodegradable nanoparticles is an important tool for the biological transport of chemical compounds. The nanoencapsulation reduces the biopharmaceutical and pharmacokinetic drawbacks of compounds and enhances their biological properties. Naturally occurring polymers such as proteins and polysacchari...

journal_title：Current medicinal chemistry

authors： Lopes VF,Giongo CN,de Almeida Campos L,Abraham WR,Mainardes RM,Khalil NM

更新日期：2020-11-24 00:00:00

abstract：:Trypanosomatids are a group of flagellated unicellular eukaryotes, causing serious human diseases including Chagas disease (Trypanosoma cruzi), sleeping sickness (Trypanosoma brucei spp.) and Leishmaniasis (Leishmania spp.). The second messenger cAMP is involved in numerous and fundamental processes in these parasites...

journal_title：Current medicinal chemistry

authors： Schoijet AC,Sternlieb T,Alonso GD

更新日期：2019-01-01 00:00:00

abstract：:Schizophrenia is a chronic psychiatric disorder that affects about 1 in 100 people around the world and results in persistent emotional and cognitive impairments. Untreated schizophrenia leads to deterioration in quality of life and premature death. Although the clinical efficacy of dopamine D2 receptor antagonists ag...

journal_title：Current medicinal chemistry

authors： Jankowska A,Satała G,Partyka A,Wesołowska A,Bojarski AJ,Pawłowski M,Chłoń-Rzepa G

更新日期：2019-01-01 00:00:00

abstract：:Novel molecular genetic approaches, at genome-scale in different species allowed characterizing genes that have undergone recent selection. The interest in this research field is not limited to the natural curiosity about our evolutionary past, but it is also to identify novel susceptibility genes for neuropsychiatic ...

journal_title：Current medicinal chemistry

authors： Moalic JM,Le Strat Y,Lepagnol-Bestel AM,Ramoz N,Loe-Mie Y,Maussion G,Gorwood P,Simonneau M

更新日期：2010-01-01 00:00:00

abstract：:Nowadays, the use of synthetic carriers as biochemical reagents and immunogens is entering a new phase. The multimeric nature of these constructs, the unambiguous composition and the ease, reliability and versatility of their production, make this type of carriers well-suited to various biotechnological and biochemica...

journal_title：Current medicinal chemistry

authors： Alexopoulos Ch,Sakarellos-Daitsiotis M,Sakarellos C

更新日期：2005-01-01 00:00:00

abstract：:The inhibition of protein degradation through the ubiquitin-proteasome pathway is a recently developed approach to cancer treatment which extends the range of cellular targets for chemotherapy. This therapeutic strategy is very interesting since the proteasomes carry out the regulated degradation of unnecessary or dam...

journal_title：Current medicinal chemistry

authors： Gilardini A,Marmiroli P,Cavaletti G

更新日期：2008-01-01 00:00:00

abstract：:Inosine 5'-monophosphate dehydrogenase (IMPDH) catalyzes the first committed step of guanosine 5'-monophosphate (GMP) biosynthesis, and thus regulates the guanine nucleotide pool, which in turn governs proliferation. Human IMPDHs are validated targets for immunosuppressive, antiviral and anticancer drugs, but as yet m...

journal_title：Current medicinal chemistry

authors： Hedstrom L,Liechti G,Goldberg JB,Gollapalli DR

更新日期：2011-01-01 00:00:00

abstract：:Although the understanding the pathophysiology of atherogenesis and atherosclerosis progression has been one of the major goals of cardiovascular research during the last decades, the precise mechanisms underlying plaque destabilization are still unknown. The disruption of the plaque and the thrombosis in the lumen th...

journal_title：Current medicinal chemistry

authors： Cominacini L,Garbin U,Mozzini C,Stranieri C,Pasini A,Solani E,Tinelli IA,Pasini AF

更新日期：2015-01-01 00:00:00

abstract：:Type 2 diabetes mellitus (DM) is a public health burden and its co-existence with hypertension is long established in the context of the metabolic syndrome. Both DM and hypertension are major risk factors, for end-stage renal disease, cardiovascular events and mortality. Strict blood pressure (BP) control in diabetics...

journal_title：Current medicinal chemistry

authors： Loutradis C,Papadopoulou E,Angeloudi E,Karagiannis A,Sarafidis P

更新日期：2020-01-01 00:00:00

abstract：:Neonatal brain hemorrhage (NBH) of prematurity is an unfortunate consequence of preterm birth. Complications result in shunt dependence and long-term structural changes such as posthemorrhagic hydrocephalus, periventricular leukomalacia, gliosis, and neurological dysfunction. Several animal models are available to stu...

journal_title：Current medicinal chemistry

authors： Lekic T,Klebe D,Poblete R,Krafft PR,Rolland WB,Tang J,Zhang JH

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Serotonin reuptake inhibitors (SRIs) and cognitive-behavioral psychotherapy (CBT) are first-line treatments for obsessive-compulsive disorder (OCD). Since response is often inadequate, in recent years researchers investigated whether combining CBT and SRIs, either ab initio or sequentially, results in a grea...

journal_title：Current medicinal chemistry

authors： Albert U,Di Salvo G,Solia F,Rosso G,Maina G

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:Considerable evidence demonstrates the importance of dithiocarbamates especially disulfiram as anticancer drugs. However there are no systematic reviews outlining how their metal-binding ability is related to their anticancer activity. This review aims to summarize chemical features and metal-binding activit...

journal_title：Current medicinal chemistry

authors： Viola-Rhenals M,Patel KR,Jaimes-Santamaria L,Wu G,Liu J,Dou QP

更新日期：2018-02-12 00:00:00

abstract：:Rubus species (family Rosaceae) have been cultivated for centuries for their fruits. These and other parts of the plants have been used traditionally for therapeutic purposes. This article highlights these and the potential they can offer. The constituents reported in the various species and those demonstrated to exhi...

journal_title：Current medicinal chemistry

authors： Patel AV,Rojas-Vera J,Dacke CG

更新日期：2004-06-01 00:00:00

abstract：: ...

journal_title：Current medicinal chemistry

authors： Biava PM,Nicolini A

更新日期：2019-01-01 00:00:00

abstract：:Ca(2+) is a highly versatile intracellular second messenger in the central nervous system, and regulates many complicated cellular processes, including excitation, plasticity and apoptosis. Influx of Ca(2+) from the extracellular fluid is required for sustained elevation of the cytosolic Ca(2+) concentration and full ...

journal_title：Current medicinal chemistry

authors： Yagami T,Kohma H,Yamamoto Y

更新日期：2012-01-01 00:00:00

abstract：:Dendritic cells (DCs) are the most powerful antigen-presenting cells which link the innate and adaptive immune responses. Depending on the context DCs initiate the immune responses or contribute to immune tolerance. Any disturbance in their phenotypes and functions may initiate inflammatory or autoimmune diseases. Hen...

journal_title：Current medicinal chemistry

authors： Rahimi K,Hassanzadeh K,Khanbabaei H,Haftcheshmeh SM,Ahmadi A,Izadpanah E,Mohammadi A,Sahebkar A

更新日期：2020-05-14 00:00:00

abstract：:COX-2, a key enzyme that catalyzed the rate-limiting steps in the conversion of arachidonic acid to prostaglandins, played a pivotal role in inflammatory process. Different from other family members, COX-2 was barely detectable in normal physiological conditions and highly inducible during acute inflammatory response ...

journal_title：Current medicinal chemistry

authors： Cui J,Jia J

更新日期：2020-09-17 00:00:00

abstract：:This invited review on the beneficial effects of nutraceuticals in the gastrointestinal tract reports previous work conducted by the authors as well as the work by other researchers in this expanding field. The text of our article on several occasions reports sentences very similar or identical to those which appear i...

journal_title：Current medicinal chemistry

authors： Romano M

更新日期：2014-01-01 00:00:00

abstract：:In this review, we report the functionalization of textiles composed of nanoscale reactive materials in the treatment of wounds and skin diseases such as acne. In view of the growing demand for high-quality textiles, much research is focused on the creation of antimicrobial finishings for fabrics, in order to protect ...

journal_title：Current medicinal chemistry

authors： Gedanken A,Perkas N,Perelshtein I,Lipovsky A

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:The evolutionarily conserved Hedgehog (Hh) signaling cascade is one of the key mediators of embryonic development of many metazoans. This pathway has been extensively targeted by small molecule inhibitors as its misregulation leads to various malignancies and developmental disorders. Thus, blocking this path...

journal_title：Current medicinal chemistry

authors： Khatra H,Bose C,Sinha S

更新日期：2017-01-01 00:00:00

abstract：:Ambient level of gamma -aminobutyric acid (GABA), the major inhibitory neurotransmitter of the brain is mediated by neuronal and glial GABA transporters (GATs), members of the sodium and chloride ion-dependent solute carrier family. The neuronal GABA transporter subtype (GAT-1) has already been proven to be the target...

journal_title：Current medicinal chemistry

authors： Kardos J,Palló A,Bencsura A,Simon A

更新日期：2010-01-01 00:00:00

abstract：:A number of amine-boranes and related derivatives possess a wide range of biological activities including antineoplastic, antiviral, hypolipidemic, anti-inflammatory activities, anti-osteoporotic and dopamine receptor antagonist activities. The compounds include borane complexes of alpha-amino acids, aromatic, aliphat...

journal_title：Current medicinal chemistry

authors： Burnham BS

更新日期：2005-01-01 00:00:00

abstract：:In the long human tradition honey has been used not only as a nutrient but also as a medicine. Its composition is rather variable and depends on the floral source and on external factors, such as seasonal, environmental conditions and processing. In this review, specific attention is focused on absorption, metabolism,...

journal_title：Current medicinal chemistry

authors： Alvarez-Suarez JM,Giampieri F,Battino M

更新日期：2013-01-01 00:00:00

abstract：:Nature continues to be the main source of inspiration for synthetic chemists in their quest to make novel conjugates, which can have different physical, biological and medicinal properties. Nature makes these conjugates from mixed biosynthesis and some of these chimeras are found to exhibit unusual biological properti...

journal_title：Current medicinal chemistry

authors： Salunke DB,Hazra BG,Pore VS

更新日期：2006-01-01 00:00:00