Abstract:
:alpha-Galactosylceramide (alpha-GalCer), is a glycolipid which has been identified as a ligand recognized by a special group of immune T cells, known as invariant NKT cells. alpha-GalCer can powerfully activate invariant NKT cells to produce immunoregulatory cytokines, including interferon-gamma and IL-4, and thereby exert a variety of subsequent effects on other cells in the immune system. Recent studies have revealed the mechanism of alpha-GalCer-induced iNKT cell-activation in immune responses to tumors and microbes, and in the suppression of autoimmune diseases. In this review, we discuss the potential immunomodulatory activity of alpha-GalCer and its possible future application for clinical studies in humans.
journal_name
Curr Med Chemjournal_title
Current medicinal chemistryauthors
Hayakawa Y,Godfrey DI,Smyth MJdoi
10.2174/0929867043456115subject
Has Abstractpub_date
2004-01-01 00:00:00pages
241-52issue
2eissn
0929-8673issn
1875-533Xjournal_volume
11pub_type
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