A role of GABA analogues in the treatment of neurological diseases.

Abstract:

:gamma-Amino butyric acid is an extremely important inhibitory neurotransmitter in the mammalian central nervous system and is essential for the overall balance between neuronal excitation and inhibition. It is well documented that GABA deficiency is associated with several important neurological disorders such as Huntington's chorea, Parkinson's and Alzheimer's disease and other psychiatric disorders, like anxiety, depression, pain, panic, or mania. Although, it is known that increasing the brain concentration of GABA prevents convulsions, the high polarity and flexible structure of this compound are probably responsible for its inefficiency as an anticonvulsant when administered orally or intravenously. To resolve this problem, GABA analogues are being designed. Over recent years, there has been increasing interest in the synthesis and pharmacological effect of new GABA derivatives, which can be considered as potent drugs in the treatment of neurodegenerative disorders.

journal_name

Curr Med Chem

authors

Gajcy K,Lochyński S,Librowski T

doi

10.2174/092986710791698549

subject

Has Abstract

pub_date

2010-01-01 00:00:00

pages

2338-47

issue

22

eissn

0929-8673

issn

1875-533X

pii

BSP/CMC/E-Pub/ 152

journal_volume

17

pub_type

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