Abstract:
:gamma-Amino butyric acid is an extremely important inhibitory neurotransmitter in the mammalian central nervous system and is essential for the overall balance between neuronal excitation and inhibition. It is well documented that GABA deficiency is associated with several important neurological disorders such as Huntington's chorea, Parkinson's and Alzheimer's disease and other psychiatric disorders, like anxiety, depression, pain, panic, or mania. Although, it is known that increasing the brain concentration of GABA prevents convulsions, the high polarity and flexible structure of this compound are probably responsible for its inefficiency as an anticonvulsant when administered orally or intravenously. To resolve this problem, GABA analogues are being designed. Over recent years, there has been increasing interest in the synthesis and pharmacological effect of new GABA derivatives, which can be considered as potent drugs in the treatment of neurodegenerative disorders.
journal_name
Curr Med Chemjournal_title
Current medicinal chemistryauthors
Gajcy K,Lochyński S,Librowski Tdoi
10.2174/092986710791698549subject
Has Abstractpub_date
2010-01-01 00:00:00pages
2338-47issue
22eissn
0929-8673issn
1875-533Xpii
BSP/CMC/E-Pub/ 152journal_volume
17pub_type
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