Peptide immunotherapies in Type 1 diabetes: lessons from animal models.

abstract：:Currently available therapeutic options for non-insulin-dependent diabetes mellitus, such as dietary modification, oral hypoglycemics, and insulin, have limitations of their own. Many natural products and herbal medicines have been recommended for the treatment of diabetes. The present paper reviews medicinal plants t...

journal_title：Current medicinal chemistry

authors： Jung M,Park M,Lee HC,Kang YH,Kang ES,Kim SK

更新日期：2006-01-01 00:00:00

abstract：:Nonsteroidal anti-inflammatory drugs (NSAIDs) are among the most commonly used drugs worldwide. Nevertheless, their intake is frequently associated with gastrointestinal side effects, representing still an important medical and socio-economic problem. In recent years efforts focused on the development of highly select...

journal_title：Current medicinal chemistry

authors： Abdel-Tawab M,Zettl H,Schubert-Zsilavecz M

更新日期：2009-01-01 00:00:00

abstract：:Systemic Lupus Erythematosus (SLE) is a chronic and relapsing heterogenous autoimmune disease that primarily affects women of reproductive age. Genetic and environmental risk factors are involved in the pathogenesis of SLE, and susceptibility genes have recently been identified. However, as gene therapy is far from cl...

journal_title：Current medicinal chemistry

authors： Pan Q,Guo Y,Guo L,Liao S,Zhao C,Wang S,Liu HF

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:Antimicrobial resistance is found in all microorganisms and has become one of the biggest threats to global health. New antimicrobials with different action mechanisms are effective weapons to fight against antibiotic-resistance. OBJECTIVE:This review aims to find potential drugs which can be further develo...

journal_title：Current medicinal chemistry

authors： Yi L,Lü X

更新日期：2019-01-01 00:00:00

abstract：:Apolipoprotein B -containing lipoproteins include triglyceride-rich lipoproteins (chylomicrons and their remnants, and very low-density lipoproteins and their remnants) and cholesterol-rich low-density lipoprotein particles. Of these, lipoproteins having sizes below 70-80 nm may enter the arterial wall, where they acc...

journal_title：Current medicinal chemistry

authors： Öörni K,Lehti S,Sjövall P,Kovanen PT

更新日期：2019-01-01 00:00:00

abstract：:Cocaine is one of the most used psychomotor stimulants all over the world. On this basis, the interest for the pharmacological activity and the pharmacodynamic and pharmacokinetic aspects of this drug is very prominent in both clinical and forensic toxicological environments. The review presents and discusses 65 scien...

journal_title：Current medicinal chemistry

authors： Bortolotti F,Gottardo R,Pascali J,Tagliaro F

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:The genus Achillea L. is rich in bioactive sesquiterpenes and flavonoids; most of the studied species exhibit several biological activities and are used as emmenagogue, wound healing and analgesic agents. Some species are also used in local folklore medicine. OBJECTIVE:Following a literature survey, we disc...

journal_title：Current medicinal chemistry

authors： Papakosta K,Grafakou ME,Barda C,Kostopoulos IV,Tsitsilonis O,Skaltsa H

更新日期：2020-01-01 00:00:00

abstract：:Current strategies in pharmaceutical research comprise two methodologically different but complementary approaches for lead finding purposes, namely the random screening of compound libraries and the structure-based effort, commonly termed rational drug design. The structure-based approach is aimed to exploit 3D struc...

journal_title：Current medicinal chemistry

authors： Müller G

更新日期：2000-09-01 00:00:00

abstract：:Fabry disease (FD) is an X-linked glycosphingolipid storage disorder caused by deficient activity of the lysosomal enzyme alpha-galactosidase A. This leads to a progressive accumulation of globotriaosylceramide (Gb3) in the lysosomes of different cells and tissues, causing principally ventricular hypertrophy, renal fa...

journal_title：Current medicinal chemistry

authors： Caballero L,Climent V,Hernández-Romero D,Quintanilla MA,de la Morena G,Marín F

更新日期：2010-01-01 00:00:00

abstract：:Paclitaxel has been proven to be effective against different types of cancer. A delivery system loaded with paclitaxel at tumor site should provide a high local concentration of the drug detrimental to malignant cells, which prevents the re-growth and metastasis of tumor. In this review, paclitaxel formulations for sy...

journal_title：Current medicinal chemistry

authors： Pawar R,Shikanov A,Vaisman B,Domb AJ

更新日期：2004-02-01 00:00:00

abstract：:Although glial proliferation of the epileptic loci is recognized for more than a century in certain focal epilepsies, the role of astrocytes in epileptic conditions is receiving significant attention only in recent years. The present review will highlight current knowledge about the various ways astrocytes control neu...

journal_title：Current medicinal chemistry

authors： Héja L

更新日期：2014-01-01 00:00:00

abstract：:Among naturally occurring isoflavones, soy isoflavones are an important class with various biological activities. Due to their phytoestrogenic structure, their effects on the brain are profound thus making the neurobiological effects of these compounds an active area of research. One such compound is daidzein, which h...

journal_title：Current medicinal chemistry

authors： Ahmed T,Javed S,Tariq A,Budzyńska B,D'Onofrio G,Daglia M,Nabavi SF,Nabavi SM

更新日期：2017-01-01 00:00:00

abstract：:Histone Deacetylase (HDAC) inhibitors are a relatively new class of anti-cancer agents that play important roles in epigenetic or non-epigenetic regulation, inducing death, apoptosis, and cell cycle arrest in cancer cells. Recently, their use has been clinically validated in cancer patients resulting in the approval b...

journal_title：Current medicinal chemistry

authors： Cappellacci L,Perinelli DR,Maggi F,Grifantini M,Petrelli R

更新日期：2020-01-01 00:00:00

abstract：:Many serious inflammatory disorders and nutrient deficiencies induce chronic pain, and anti-inflammatory diets have been applied successfully to modify the inflammatory symptoms causing chronic pain. Numerous scientific data and clinical investigations have demonstrated that long-term inflammation could lead to an ina...

journal_title：Current medicinal chemistry

authors： Bjørklund G,Chirumbolo S,Dadar M,Pen JJ,Doşa MD,Pivina L,Semenova Y,Aaseth J

更新日期：2020-01-01 00:00:00

abstract：:Polymyxins are polypeptide antibiotics, with a primary effect of membrane damaging due to their selective binding to the lipopolysaccharide of Gram-negative bacteria. Their nephro- and neurotoxic side effects limited their use, however, in the last decade the emergence of multidrug-resistant Gram-negative bacteria led...

journal_title：Current medicinal chemistry

authors： Kadar B,Kocsis B,Nagy K,Szabo D

更新日期：2013-01-01 00:00:00

abstract：:This review presents the detailed account of factors leading to cancer and design strategy for the synthesis of benzimidazole derivatives as anticancer agents. The recent survey for cancer treatment in Cancer facts and figures 2017 American Chemical Society has shown progressive development in fighting cancer. Researc...

journal_title：Current medicinal chemistry

authors： Akhtar MJ,Yar MS,Sharma VK,Khan AA,Ali Z,Haider MDR,Pathak A

更新日期：2020-01-01 00:00:00

abstract：:The use of dopaminergic agonists is key in the treatment of Parkinson's disease and related central nervous system (CNS) neurodegenerative disorders. Despite there are a number of commercialized dopaminergic agonists that are currently being used successfully in the first stages of the disease, they often fail to prov...

journal_title：Current medicinal chemistry

authors： Matute MS,Matute R,Merino P

更新日期：2016-01-01 00:00:00

abstract：:Epinephrine and Norepinephrine, typically released during stress bind to nine different adrenoceptors (AR) which classically control the cardiovascular and respiratory systems. New targets were described for the many agonists and antagonists developed for these AR, as the central nervous system. During the last three ...

journal_title：Current medicinal chemistry

authors： Lüthy IA,Bruzzone A,Piñero CP,Castillo LF,Chiesa IJ,Vázquez SM,Sarappa MG

更新日期：2009-01-01 00:00:00

abstract：:Hereditary amyloidogenic transthyretin (TTR) (ATTR) amyloidosis is an autosomal dominant form of fatal hereditary amyloidosis. Owing to progress in biochemical and molecular genetic analyses, this disease is now believed to occur worldwide. As of today, reports of about 120 different points of single or double mutatio...

journal_title：Current medicinal chemistry

authors： Ando Y,Ueda M

更新日期：2012-01-01 00:00:00

abstract：:Drug repositioning is an important area of biomedical research. The drug repositioning studies have shifted to computational approaches. Large-scale perturbation databases, such as the Connectivity Map and the Library of Integrated Network-Based Cellular Signatures, contain a number of chemical-induced gene expression...

journal_title：Current medicinal chemistry

authors： Wang F,Lei X,Wu FX

更新日期：2020-01-01 00:00:00

abstract：:The Src family consists of eight non-receptor protein tyrosine kinases characterised by a common structure. Based on their amino acid sequence, Src family kinases are grouped into two subfamilies, which are also characterised by different tissue specificity. Src kinases are involved in signal transduction pathways tri...

journal_title：Current medicinal chemistry

authors： Benati D,Baldari CT

更新日期：2008-01-01 00:00:00

abstract：:To this point, efforts to develop therapeutic peptides for intracellular applications were guided by the perception that unmodified linear peptides are highly unstable and therefore structural modifications are required to reduce proteolytic breakdown. Largely, this concept is a consequence of the fact that most resea...

journal_title：Current medicinal chemistry

authors： Zuconelli CR,Brock R,Adjobo-Hermans MJW

更新日期：2017-01-01 00:00:00

abstract：:Homocysteine is a thiol aminoacid synthesized during the metabolism of methionine. Increased plasma levels of homocysteine can be the result of mutations in the enzymes responsible for homocysteine metabolism, particularly cystathionine-beta synthase (CBS) and 5,10-methylenetetrahydrofolate reductase (MTHFR). Addition...

journal_title：Current medicinal chemistry

authors： Pezzini A,Del Zotto E,Padovani A

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:Inflammation is one of the most misunderstood aspects of human health. People have been encouraged to eat foods that have a high antioxidant capacity, and in vitro tests for total antioxidant capacity emerged. They were based on measuring the destruction of oxidized test compounds in direct reactions with th...

journal_title：Current medicinal chemistry

authors： Smith RE

更新日期：2020-01-01 00:00:00

abstract：:Bile formation is an osmotic process driven by the vectorial transport of actively transferred biliary components across the basolateral (sinusoidal) and apical (canalicular) hepatocyte membranes, the latter being the rate-limiting step of the overall blood-to-bile transfer. The ATP-binding cassette (ABC) superfamily ...

journal_title：Current medicinal chemistry

authors： Crocenzi FA,Mottino AD,Roma MG

更新日期：2004-02-01 00:00:00

abstract：:Characterization of liver-specific autoantigens has given a fresh impetus to research in the pathogenesis of autoimmune liver diseases, viral-triggered and drug-induced autoimmunity affecting the liver. Intriguing is the fact that most of the liver-specific autoantigens are enzymes of key importance for cell's homeost...

journal_title：Current medicinal chemistry

authors： Bogdanos DP,Dalekos GN

更新日期：2008-01-01 00:00:00

abstract：:Chymase stored in mast cells activates matrix metalloproteinase (MMP)-9, which may relate to the progression of sinusoidal obstruction syndrome (SOS). We investigated the preventive effect of a chymase inhibitor, TY-51469, on monocrotaline-induced SOS in hamsters. Hamsters were orally administrated with a single dose ...

journal_title：Current medicinal chemistry

authors： Masubuchi S,Komeda K,Takai S,Jin D,Tashiro K,Li ZL,Otsuki Y,Okamura H,Hayashi M,Uchiyama K

更新日期：2013-01-01 00:00:00

abstract：:This review covers recent literature from 2012-2019 concerning 170 marine natural products and their semisynthetic analogues with strong anticancer biological activities. Reports that shed light on cellular and molecular mechanisms and biological functions of these compounds, thus advancing the understanding in cancer...

journal_title：Current medicinal chemistry

authors： Matulja D,Wittine K,Malatesti N,Laclef S,Turks M,Markovic MK,Ambrožić G,Marković D

更新日期：2020-01-01 00:00:00

abstract：:Chemoprevention is based on the use of non-toxic, pharmacologically active agents to prevent tumor progression. In this regard, natural dietary agents have been described by the most recent literature as promising tools for controlling onset and progression of malignancies. Extensive research has been so far performed...

journal_title：Current medicinal chemistry

authors： Raimondi L,De Luca A,Giavaresi G,Barone A,Tagliaferri P,Tassone P,Amodio N

更新日期：2020-01-01 00:00:00

abstract：:Bioactivation of xenobiotics can, in certain circumstances, result in the formation of reactive electrophilic species. These reactive metabolites may covalently modify proteins and macromolecules and it has been suggested that protein modification is a key initial step in provoking idiosyncratic adverse drug reactions...

journal_title：Current medicinal chemistry

authors： Edwards PJ,Sturino C

更新日期：2011-01-01 00:00:00