A Review of Drug Repositioning Based Chemical-induced Cell Line Expression Data.

Abstract:

:Drug repositioning is an important area of biomedical research. The drug repositioning studies have shifted to computational approaches. Large-scale perturbation databases, such as the Connectivity Map and the Library of Integrated Network-Based Cellular Signatures, contain a number of chemical-induced gene expression profiles and provide great opportunities for computational biology and drug repositioning. One reason is that the profiles provided by the Connectivity Map and the Library of Integrated Network-Based Cellular Signatures databases show an overall view of biological mechanism in drugs, diseases and genes. In this article, we provide a review of the two databases and their recent applications in drug repositioning.

journal_name

Curr Med Chem

authors

Wang F,Lei X,Wu FX

doi

10.2174/0929867325666181101115801

subject

Has Abstract

pub_date

2020-01-01 00:00:00

pages

5340-5350

issue

32

eissn

0929-8673

issn

1875-533X

pii

CMC-EPUB-94203

journal_volume

27

pub_type

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