Abstract:
:Akuammiline alkaloids are a family of monoterpene indole alkaloids of renewed medicinal interest. These bases act as ligands for a heterogeneous group of molecular targets and, consequently, display a wide variety of pharmacological activities. For example, pseudoakuammigine (2) exhibits opioid activity in vivo, echitamine (4) has been reported to have promising cytotoxic activity, and corymine (121) behaves as an antagonist of the glycine receptor. Oddly enough, these alkaloids have not raised enough interest in the organic synthesis community, remaining inaccessible; even the entry to their pentacyclic framework continues elusive. Recently, several akuammiline bases have been isolated and identified including bisindole alkaloids, such as vingramine (103) or rausutrine (110), which incorporate akuammiline-type subunits. This review covers the advances in the chemistry and pharmacology of akuammiline alkaloids reported within the last ten years.
journal_name
Curr Med Chemjournal_title
Current medicinal chemistryauthors
Ramírez A,García-Rubio Sdoi
10.2174/0929867033457016subject
Has Abstractpub_date
2003-09-01 00:00:00pages
1891-915issue
18eissn
0929-8673issn
1875-533Xjournal_volume
10pub_type
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