Nanostructured biomaterials with antimicrobial properties.

abstract：:Cellular resistance to anthracyclines is a major limitation of their clinical use in the treatment of human tumors. Resistance to doxorubicin is described as a multifactorial phenomenon involving the overexpression of defense factors and alterations in drug-target interactions. Such changes do not account for all mani...

journal_title：Current medicinal chemistry

authors： Perego P,Corna E,De Cesare M,Gatti L,Polizzi D,Pratesi G,Supino R,Zunino F

更新日期：2001-01-01 00:00:00

abstract：:Radical induced oxidative damage is extremely harmful to tissues and organs due to molecular modifications brought to polyunsaturated membrane lipids, proteins and nucleic acids. Oxidative stress is believed to be one of the pathophysiological mechanisms that operate in neurodegenerative disorders such as cerebral isc...

journal_title：Current medicinal chemistry

authors： Goldstein S,Lestage P

更新日期：2000-12-01 00:00:00

abstract：:The kidney has numerous complex interactions with the heart, including shared risk factors (e.g., hypertension, dyslipidemia, etc.) and mutual amplification of morbidity and mortality. Both cardiovascular diseases and chronic kidney disease (CKD) may cause various alterations in cardiovascular system, metabolic homeos...

journal_title：Current medicinal chemistry

authors： Potpara TS,Jokic V,Dagres N,Marin F,Prostran MS,Blomstrom-Lundqvist C,Lip GY

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:Resveratrol, a natural polyphenol product, is used in plant defense from fungal and microbial aggression. It is found naturally, especially in plants such as grapes, peanuts, and berries. It has the highest concentrations in blueberries, mulberries, blackberries, and the skin of red grapes. Resveratrol has v...

journal_title：Current medicinal chemistry

authors： Kumar S,Chang YC,Lai KH,Hwang TL

更新日期：2020-09-17 00:00:00

abstract：:The stilbene scaffold is a basic element for a number of biologically active natural and synthetic compounds, and it is considered as a privileged structure. Stilbenes exemplified by resveratrol, combretastatin A-4 and pterostilbene are of significant interest for drug research and development because of their potenti...

journal_title：Current medicinal chemistry

authors： Giacomini E,Rupiani S,Guidotti L,Recanatini M,Roberti M

更新日期：2016-01-01 00:00:00

abstract：:The immunophilin ligands cyclosporin A, FK506 and rapamycin are best known for their immunosuppressive properties and their clinical use in transplantation medicine. These compounds or their analogs are also clinically used or investigated in various types of cancer, coronary angioplasty, dermatology, hepatitis C infe...

journal_title：Current medicinal chemistry

authors： Gaali S,Gopalakrishnan R,Wang Y,Kozany C,Hausch F

更新日期：2011-01-01 00:00:00

abstract：:Tumor necrosis factor (TNF, TNF-α, cachectin) is a pleiotropic, proinflammatory cytokine with multiple biological effects, many of which are not yet fully understood. Although TNF was initially described as an anti-tumor agent more than three decades ago, current knowledge places it central to immune system homeostasi...

journal_title：Current medicinal chemistry

authors： Richmond V,Michelini FM,Bueno CA,Alché LE,Ramírez JA

更新日期：2015-01-01 00:00:00

abstract：:Obesity and metabolic syndrome represent major public health problems, and are the biggest preventable causes of death worldwide. Obesity is the leading risk factor for type 2 diabetes mellitus (T2DM), cardiovascular diseases and non-alcoholic fatty liver disease. Obesity-associated insulin resistance, which is charac...

journal_title：Current medicinal chemistry

authors： Panzhinskiy E,Ren J,Nair S

更新日期：2013-01-01 00:00:00

abstract：:Cocaine is one of the most used psychomotor stimulants all over the world. On this basis, the interest for the pharmacological activity and the pharmacodynamic and pharmacokinetic aspects of this drug is very prominent in both clinical and forensic toxicological environments. The review presents and discusses 65 scien...

journal_title：Current medicinal chemistry

authors： Bortolotti F,Gottardo R,Pascali J,Tagliaro F

更新日期：2012-01-01 00:00:00

abstract：:Enteroviruses are members of picornavirus family which causes diverse and severe diseases in humans and animals. Clinical manifestations of enterovirus infections include fever, hand, foot, and mouth disease, and herpangina. Enteroviruses also cause potentially severe and life-threatening infections such as meningitis...

journal_title：Current medicinal chemistry

authors： Li C,Wang H,Shih SR,Chen TC,Li ML

更新日期：2007-01-01 00:00:00

abstract：:With the increasing production of engineered nanomaterials (ENMs) exploited in many consumer products, a wider number of people is expected to be exposed to such materials in the near future, both in occupational and environmental settings. This has raised concerns about the possible implications on public health. In ...

journal_title：Current medicinal chemistry

authors： Campagnolo L,Massimiani M,Magrini A,Camaioni A,Pietroiusti A

更新日期：2012-01-01 00:00:00

abstract：:Mitochondria are organelles which play an important role not only in cellular metabolism but also in controlling pathways related with cell death, ionic and redox regulation. Alterations in mitochondrial metabolism are implicated in a variety of diseases, including cancer. Cellular and mitochondrial metabolism are bot...

journal_title：Current medicinal chemistry

authors： Deus CM,Santos GL,Loureiro R,Vega-Naredo I,Faneca H,Oliveira PJ

更新日期：2015-01-01 00:00:00

abstract：:Microcin J25 (MccJ25) is a plasmid-encoded peptide of 21 L-amino acids (G1-G-A-G-H5-V-P-E-Y-F10-V-G-I-G-T15-P-I-S-F-Y20-G), excreted to the medium by an Escherichia coli strain. MccJ25 is active on Gram-negative bacteria related to the producer strain, including some pathogenic strains. The four-plasmid genes mcjABCD,...

journal_title：Current medicinal chemistry

authors： Vincent PA,Morero RD

更新日期：2009-01-01 00:00:00

abstract：:Tumor necrosis factor (TNF) is a cytokine with well known anticancer properties and is being utilized as anticancer agent for the treatment of patients with locally advanced solid tumors. However, TNF role in cancer biology is debated. In fact, in spite of the wealth of evidence supporting its antitumor activity, the ...

journal_title：Current medicinal chemistry

authors： Bertazza L,Mocellin S

更新日期：2010-01-01 00:00:00

abstract：:In order to ascertain the role of dietary flavonoids as antioxidants in vivo it is necessary to understand the chemical nature of the absorbed forms in the circulation in vivo and how the multiplicity of research findings in vitro reflect the bioactivity of flavonoids in vivo. Only when we gain adequate information on...

journal_title：Current medicinal chemistry

authors： Rice-Evans C

更新日期：2001-06-01 00:00:00

abstract：:Platinum complex-based chemotherapy is one of the major treatment options of many malignancies. Although severe side effects occur, and only a limited spectrum of tumors can be cured, Pt compounds are used in every second therapy scheme. Thus, many different drug design strategies have been employed for improving the ...

journal_title：Current medicinal chemistry

authors： Hartinger CG,Nazarov AA,Ashraf SM,Dyson PJ,Keppler BK

更新日期：2008-01-01 00:00:00

abstract：:Non-alcoholic fatty liver disease is regarded as the hepatic manifestation of metabolic syndrome and is an important and common cause of chronic liver disease with a potential to develop end-stage liver disease. While important advances in the pathophysiology have been achieved using genetically modified and diet-indu...

journal_title：Current medicinal chemistry

authors： Chavez-Tapia NC,Rosso N,Tiribelli C

更新日期：2011-01-01 00:00:00

abstract：:Combination therapy in the treatment of viral infections in which, for example, three different drugs against three different targets on three independent proteins are administered, has been highly successful clinically. However, it is only a matter of time before a virus will arise resistant to all three drugs, becau...

journal_title：Current medicinal chemistry

authors： Mangel WF,McGrath WJ,Brown MT,Baniecki ML,Barnard DL,Pang YP

更新日期：2001-07-01 00:00:00

abstract：:Chronic obstructive pulmonary disease (COPD) represents a heightened inflammatory response in the lung generally resulting from tobacco smoking-induced recruitment and activation of inflammatory cells and/or activation of lower airway structural cells. Several mediators can modulate activation and recruitment of these...

journal_title：Current medicinal chemistry

authors： Nucera F,Lo Bello F,Shen SS,Ruggeri P,Coppolino I,Di Stefano A,Stellato C,Casolaro V,Hansbro PM,Adcock IM,Caramori G

更新日期：2020-08-19 00:00:00

abstract：:A dramatical decline in human male reproductive function has been reported for the past 20 years. Many recent epidemiological, clinical and experimental findings suggest that the reproductive dysfunction could result from prenatal and neonatal chemical compound exposure. Even if numerous studies argue for a relationsh...

journal_title：Current medicinal chemistry

authors： Gilleron J,Malassiné A,Carette D,Segretain D,Pointis G

更新日期：2011-01-01 00:00:00

abstract：:The development of new drugs with potential therapeutic applications is one of the most complex and difficult process in the pharmaceutical industry. Millions of dollars and man-hours are devoted to the discovery of new therapeutical agents. As, the activity of a drug is the result of a multitude of factors such as bi...

journal_title：Current medicinal chemistry

authors： Ooms F

更新日期：2000-02-01 00:00:00

abstract：:Multitarget-directed ligands (MTDLs), an emerging and appealing drug discovery strategy, utilizing a single chemical entity to inhibit multitargets, was confirmed to be effective in reducing the likelihood of drug resistance, diminishing problems of dosing complexity, drug-drug interactions and toxicities, as well as ...

journal_title：Current medicinal chemistry

authors： Zhan P,Liu X

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Leukotrienes (LTs) constitute a bioactive group of polyunsaturated fatty acid (PUFA) metabolites molded by the enzymatic activity of lipoxygenase (LO) and have a pivotal role in inflammation and allergy. Evidence is accumulating both by in vitro cell culture experiments and animal tumor model studies in supp...

journal_title：Current medicinal chemistry

authors： Mahboubi-Rabbani M,Zarghi A

更新日期：2019-12-09 00:00:00

abstract：:Analytical chemists have increasingly turned their attention to drug discovery and drug analysis and to solve fundamental questions of biological significance in physiology and genetics. New technologies have been developed, and a variety of instruments have been redesigned for biomedical applications. The development...

journal_title：Current medicinal chemistry

authors： Hanai T

更新日期：2005-01-01 00:00:00

abstract：:Numerous compounds with a benzothiazole scaffold that have been described in the literature show promising activities against several Gram-positive and Gramnegative bacteria, and also against Mycobacterium tuberculosis. Benzothiazole-based antibacterial compounds bind to different biological targets in bacterial cells...

journal_title：Current medicinal chemistry

authors： Gjorgjieva M,Tomašič T,Kikelj D,Mašič LP

更新日期：2018-01-01 00:00:00

abstract：:Bioactivation of xenobiotics can, in certain circumstances, result in the formation of reactive electrophilic species. These reactive metabolites may covalently modify proteins and macromolecules and it has been suggested that protein modification is a key initial step in provoking idiosyncratic adverse drug reactions...

journal_title：Current medicinal chemistry

authors： Edwards PJ,Sturino C

更新日期：2011-01-01 00:00:00

abstract：:Although resin-based chemistry offers many practical advantages over conventional solution phase for the synthesis of combinatorial libraries, effective monitoring of reactions conducted on the support remains a challenge. A number of techniques have been developed to enable the analysis of solid phase organic synthes...

journal_title：Current medicinal chemistry

authors： Scicinski JJ,Congreveb MS,Kay C,Ley SV

更新日期：2002-12-01 00:00:00

abstract：BACKGROUND:Diabetic nephropathy (DN) is an important diabetic microvascular complication, and it is becoming the leading cause of end-stage renal disease worldwide. Unfortunately, there are no effective therapies to treat established DN. Therefore, new therapeutic targets are urgently required. Accumulating studies ind...

journal_title：Current medicinal chemistry

authors： Yang S,Han Y,Liu J,Song P,Xu X,Zhao L,Hu C,Xiao L,Liu F,Zhang H,Sun L

更新日期：2017-01-01 00:00:00

abstract：:G protein-coupled receptors (GPCRs) comprise a large protein family of transmembrane receptors involved in many physiological processes. They are engaged in various transduction processes of extracellular signals into intracellular responses. Due to their involvement in numerous diseases they represent an important ph...

journal_title：Current medicinal chemistry

authors： Jakobs D,Sorkalla T,Häberlein H

更新日期：2012-01-01 00:00:00

abstract：:To this point, efforts to develop therapeutic peptides for intracellular applications were guided by the perception that unmodified linear peptides are highly unstable and therefore structural modifications are required to reduce proteolytic breakdown. Largely, this concept is a consequence of the fact that most resea...

journal_title：Current medicinal chemistry

authors： Zuconelli CR,Brock R,Adjobo-Hermans MJW

更新日期：2017-01-01 00:00:00