Abstract：
BACKGROUND:Both small and large body size at birth are now known to predict a range of chronic disorders in adult life, including certain cancers. These associations are thought to reflect "fetal programming." This may lead to impairment of a small number of key systems including the immune system. Hodgkin's lymphoma is a disease of the immune system. We have therefore examined the association between Hodgkin's lymphoma and early development. Our hypothesis was that the disease would be associated with markers of poor fetal growth, specifically small body size or small placental size at birth. METHODS:Using the Finnish Cancer Registry we identified patients with Hodgkin's disease in a cohort of 20,431 people born in Helsinki during 1924-44. Each person has a detailed birth record. RESULTS:There were 12 patients with Hodgkin's disease, giving an incidence comparable to international rates. The disease was associated with prolonged gestation. For every additional week of gestation the hazard ratio was 1.37 (95% CI 1.00-1.87; p = 0.05). The disease was also associated with a short placental surface. After allowing for gestation, for each centimetre increase in surface length, the hazard ratio was 0.70 (0.53-0.92; p = 0.01). The disease was not associated with birth weight or length or maternal body size. CONCLUSIONS:We have shown that Hodgkin's lymphoma is associated with prolonged gestation and a short length of the placental surface. We speculate that Hodgkin's lymphoma is initiated by two events in fetal life. One, which is an immune event, is associated with prolonged gestation, while the other is associated with growth faltering.
journal_name
Cancer Epidemioljournal_title
Cancer epidemiologyauthors
Barker DJ,Osmond C,Thornburg KL,Kajantie E,Eriksson JGdoi
10.1016/j.canep.2013.01.004subject
Has Abstractpub_date
2013-06-01 00:00:00pages
321-3issue
3eissn
1877-7821issn
1877-783Xpii
S1877-7821(13)00008-8journal_volume
37pub_type
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