Abstract:
:We report the first application of a novel diffusion-based MRI method, called diffusional kurtosis imaging (DKI), to investigate changes in brain tissue microstructure in patients with mild cognitive impairment (MCI) and AD and in cognitively intact controls. The subject groups were characterized and compared in terms of DKI-derived metrics for selected brain regions using analysis of covariance with a Tukey multiple comparison correction. Receiver operating characteristic (ROC) and binary logistic regression analyses were used to assess the utility of regional diffusion measures, alone and in combination, to discriminate each pair of subject groups. ROC analyses identified mean and radial kurtoses in the anterior corona radiata as the best individual discriminators of MCI from controls, with the measures having an area under the ROC curve (AUC) of 0.80 and 0.82, respectively. The next best discriminators of MCI from controls were diffusivity and kurtosis (both mean and radial) in the prefrontal white matter (WM), with each measure having an AUC between 0.77 and 0.79. Finally, the axial diffusivity in the hippocampus was the best overall discriminator of MCI from AD, having an AUC of 0.90. These preliminary results suggest that non-Gaussian diffusion MRI may be beneficial in the assessment of microstructural tissue damage at the early stage of MCI and may be useful in developing biomarkers for the clinical staging of AD.
journal_name
Magn Reson Imagingjournal_title
Magnetic resonance imagingauthors
Falangola MF,Jensen JH,Tabesh A,Hu C,Deardorff RL,Babb JS,Ferris S,Helpern JAdoi
10.1016/j.mri.2013.02.008subject
Has Abstractpub_date
2013-07-01 00:00:00pages
840-6issue
6eissn
0730-725Xissn
1873-5894pii
S0730-725X(13)00088-Xjournal_volume
31pub_type
杂志文章abstract::Postero-anterior radiographs and magnetic resonance imaging (MRI) of the chest were performed in nine biopsy proven cases of sarcoidosis. MRI was more sensitive than a postero-anterior chest roentgenogram in detecting hilar and mediastinal adenopathy but less informative in detecting pleural and parenchymal disease. ...
journal_title:Magnetic resonance imaging
pub_type: 杂志文章
doi:10.1016/0730-725x(88)90131-2
更新日期:1988-09-01 00:00:00
abstract::Quantification of magnetic resonance (MR)-based relaxation parameters of tendons and ligaments is challenging due to their very short transverse relaxation times, requiring application of ultra-short echo-time (UTE) imaging sequences. We quantify both T1 and T2* in the quadriceps and patellar tendons of healthy volunt...
journal_title:Magnetic resonance imaging
pub_type: 杂志文章
doi:10.1016/j.mri.2019.07.015
更新日期:2019-11-01 00:00:00
abstract::Increased bone water content resulting from repetitive patellofemoral joint overloading has been suggested to be a possible mechanism underlying patellofemoral pain (PFP). To date, it remains unknown whether persons with PFP exhibit elevated bone water content. The purpose of this study was to determine whether recrea...
journal_title:Magnetic resonance imaging
pub_type: 杂志文章
doi:10.1016/j.mri.2014.04.018
更新日期:2014-09-01 00:00:00
abstract:BACKGROUND:The diagnosis and management of mild traumatic brain injury (MTBI) continue to be subjects of debate, with varying opinions regarding the extent to which tissue-based impairments versus the impacts of other stressors cause ongoing disability. Detecting areas of the brain with abnormalities that can explain s...
journal_title:Magnetic resonance imaging
pub_type: 杂志文章
doi:10.1016/j.mri.2011.12.018
更新日期:2012-05-01 00:00:00
abstract::Liver fibrosis determines the functional liver reserve. Several studies have reported that the apparent diffusion coefficient (ADC) values of diffusion-weighted magnetic resonance imaging (DW-MRI) can assess liver fibrosis. We investigated whether DW-MRI predicts postoperative hepatic insufficiency and liver fibrosis ...
journal_title:Magnetic resonance imaging
pub_type: 杂志文章
doi:10.1016/j.mri.2010.03.018
更新日期:2010-07-01 00:00:00
abstract::The ability to determine coil sensitivities implies that a method optimized in terms of maximized signal-to-noise ratio (SNR) can be applied to the combination of multiple coil images. An optimization of SNR subsequently results in a minimized variance in quantitative velocity measurements using phase-contrast imaging...
journal_title:Magnetic resonance imaging
pub_type: 杂志文章
doi:10.1016/j.mri.2005.06.002
更新日期:2005-09-01 00:00:00
abstract::The nonhuman primate brain study provides important supplemental means for human brain exploration since the two species share close anatomical and functional similarities. MR diffusion tensor imaging (DTI) in human brain has revealed exquisite details of brain structures especially in the brain white matter. However,...
journal_title:Magnetic resonance imaging
pub_type: 杂志文章
doi:10.1016/j.mri.2008.07.004
更新日期:2009-04-01 00:00:00
abstract::New methods for acquiring and processing gradient NMR well log data enable signals from gas, light oil, and water to be unambiguously separated and, in many cases, quantified. These methods exploit the combined effects of T1-based and diffusion-based contrast on log response. T1 contrast, which separates the water and...
journal_title:Magnetic resonance imaging
pub_type: 杂志文章
doi:10.1016/s0730-725x(96)00162-2
更新日期:1996-01-01 00:00:00
abstract::The purpose of this study was to analyze background parenchymal enhancement (BPE) in the contralateral normal breast of cancer patients during the course of neoadjuvant chemotherapy (NAC). Forty-five subjects were analyzed. Each patient had three MRIs, one baseline (B/L) and two follow-up (F/U) studies. The fibrogland...
journal_title:Magnetic resonance imaging
pub_type: 杂志文章
doi:10.1016/j.mri.2013.07.014
更新日期:2013-11-01 00:00:00
abstract::The medical specialty radiology has experienced a number of extremely important and influential technical developments in the past that have affected how medical imaging is deployed. Artificial intelligence (AI) is potentially another such development that will introduce fundamental changes into the practice of radiol...
journal_title:Magnetic resonance imaging
pub_type: 社论
doi:10.1016/j.mri.2019.12.006
更新日期:2020-05-01 00:00:00
abstract::Functional magnetic resonance imaging favors the use of multi-slice gradient-recalled echo-planar imaging due to its short image acquisition times, whole brain coverage and sensitivity to BOLD contrast. However, despite its advantages, gradient-recalled echo-planar imaging also is sensitive to static magnetic field gr...
journal_title:Magnetic resonance imaging
pub_type: 杂志文章
doi:10.1016/s0730-725x(00)00199-5
更新日期:2000-11-01 00:00:00
abstract::Fast magnetic resonance (MR) imaging provides a consistent and predictable appearance of vascular abnormalities as shown by four patients with thrombi, dissection and aneurysm. Fast MR images are obtained during breath-holding, resulting in an absence of respiratory motion artifacts. The time of MR study is much less ...
journal_title:Magnetic resonance imaging
pub_type: 杂志文章
doi:10.1016/0730-725x(88)90483-3
更新日期:1988-07-01 00:00:00
abstract::The misunderstanding of the labeling for an "MR conditional" respiratory ventilator system resulted in the placement of this device, which had substantial ferromagnetic components, too close to a 3-T magnetic resonance (MR) system, causing a projectile incident. Magnetic resonance imaging health care professionals sho...
journal_title:Magnetic resonance imaging
pub_type: 杂志文章
doi:10.1016/j.mri.2011.07.002
更新日期:2011-10-01 00:00:00
abstract:PURPOSE:To develop a protocol to non-invasively measure and map fat fraction, fat/(fat+water), as a function of age in the adult thymus for future studies monitoring the effects of interventions aimed at promoting thymic rejuvenation and preservation of immunity in older adults. MATERIALS AND METHODS:Three-dimensional...
journal_title:Magnetic resonance imaging
pub_type: 杂志文章
doi:10.1016/j.mri.2018.03.016
更新日期:2018-07-01 00:00:00
abstract::Gadolinium-based magnetic resonance (MR) contrast agents (GBCM) causes a devastating systemic fibrosing illness, nephrogenic systemic fibrosis (NSF), in patients with reduced kidney function. GBCM targets iron-recycling CD163- and ferroportin-expressing macrophages to release labile iron that mediates gadolinium toxic...
journal_title:Magnetic resonance imaging
pub_type: 杂志文章,评审
doi:10.1016/j.mri.2016.08.016
更新日期:2016-12-01 00:00:00
abstract::The general aims of functional brain magnetic resonance imaging (fMRI) studies are to ascertain which areas of the brain are activated during a specific task, the extent of this activation, whether different groups of subjects demonstrate different patterns of activation, and how these groups behave in different tasks...
journal_title:Magnetic resonance imaging
pub_type: 杂志文章
doi:10.1016/s0730-725x(97)00278-6
更新日期:1998-04-01 00:00:00
abstract::Image artifacts due to 14 gauge radiotherapy electromagnetic (EM) transponders were assessed on conventional spin echo images, and corrected using metal artifact reduction techniques: high bandwidth, view angle tilting (VAT), and slice encoding for metal artifact correction (SEMAC). Large areas of signal loss and/or p...
journal_title:Magnetic resonance imaging
pub_type: 杂志文章
doi:10.1016/j.mri.2019.02.005
更新日期:2019-06-01 00:00:00
abstract::Serious adverse reactions following the IV administration of Gd-DTPA (Magnevist, gadopenetate dimeglumine, Berlex Laboratories, Wayne, NJ), although extremely rare, can occur. As yet, there has been no published case of a severe anaphylactoid-type reaction to Gd-DTPA. ...
journal_title:Magnetic resonance imaging
pub_type: 杂志文章
doi:10.1016/0730-725x(90)90019-x
更新日期:1990-01-01 00:00:00
abstract::Positive contrast imaging methods produce enhanced signal at large magnetic field gradient in magnetic resonance imaging. Several postprocessing algorithms, such as susceptibility gradient mapping and phase gradient mapping methods, have been applied for positive contrast generation to detect the cells targeted by sup...
journal_title:Magnetic resonance imaging
pub_type: 杂志文章
doi:10.1016/j.mri.2011.04.011
更新日期:2011-09-01 00:00:00
abstract::Recent compressed sensing techniques allow signal acquisition with less sampling than required by the Nyquist-Shannon theorem which reduces the data acquisition time in magnetic resonance imaging (MRI). However, prior knowledge becomes essential to reconstruct detailed features when the sampling rate is exceedingly lo...
journal_title:Magnetic resonance imaging
pub_type: 杂志文章
doi:10.1016/j.mri.2015.10.009
更新日期:2016-02-01 00:00:00
abstract::Tissue contrast obtained using fast spin-echo (FSE) and conventional spin-echo (SE) sequences is not identical and a number of mechanisms are thought to contribute to these contrast differences. The effect of stimulated echoes has previously been apparently ruled out as a contributing mechanism. Signal-to-noise ratios...
journal_title:Magnetic resonance imaging
pub_type: 杂志文章
doi:10.1016/0730-725x(95)02110-f
更新日期:1996-01-01 00:00:00
abstract::A new approach is introduced for non-rigid registration of a pair of magnetic resonance images (MRI). It is a generalization of the demons algorithm with low computational cost, based on local information augmentation (by integrating multiple images) and balanced implementation. Specifically, a single deformation that...
journal_title:Magnetic resonance imaging
pub_type: 杂志文章
doi:10.1016/j.mri.2020.09.013
更新日期:2020-12-01 00:00:00
abstract::The adiabatic Shinnar-Le Roux (SLR) algorithm for radiofrequency (RF) pulse design enables systematic control of pulse parameters such as bandwidth, RF energy distribution and duration. Some applications, such as diffusion-weighted imaging (DWI) at high magnetic fields, would benefit from RF pulses that can provide gr...
journal_title:Magnetic resonance imaging
pub_type: 杂志文章
doi:10.1016/j.mri.2014.04.003
更新日期:2014-09-01 00:00:00
abstract::The application of a raw data-based, operator-independent MR segmentation technique to differentiate boundaries of tumor from edema or hemorrhage is demonstrated. A case of a glioblastoma multiforme with gross and histopathologic correlation is presented. The MR image data set was segmented into tissue classes based o...
journal_title:Magnetic resonance imaging
pub_type: 杂志文章
doi:10.1016/0730-725x(94)00093-i
更新日期:1995-01-01 00:00:00
abstract::The fast Fourier flow technique offers a convenient way for extremely exact flow measurements. In combination with ECG gating, arterial flow can be studied. The total acquisition time for a single measurement is about 10 s, an ECG-gated cine sequence can be acquired in about 4 min. Fast Fourier flow can, therefore, be...
journal_title:Magnetic resonance imaging
pub_type: 杂志文章
doi:10.1016/0730-725x(88)90473-0
更新日期:1988-07-01 00:00:00
abstract::We report a geographic area of prominent hypointensity in T2-weighted images vs. normal adjacent liver parenchyma in a patient with cholangiocarcinoma and lymphangitic metastasis of the liver after superparamagnetic iron oxide (SPIO) administration. The area showing this prominent signal drop showed Kupffer cell proli...
journal_title:Magnetic resonance imaging
pub_type: 杂志文章
doi:10.1016/j.mri.2007.10.012
更新日期:2008-05-01 00:00:00
abstract::Magnetic field inhomogeneities like eddy current-related gradient fields cause geometric distortions in echo-planar imaging (EPI). This in particular affects diffusion-weighted imaging where these distortions vary with the direction of the diffusion weighting and hamper the accurate determination of diffusion paramete...
journal_title:Magnetic resonance imaging
pub_type: 杂志文章
doi:10.1016/j.mri.2009.12.004
更新日期:2010-04-01 00:00:00
abstract::It is a big challenge to segment magnetic resonance (MR) images with intensity inhomogeneity. The widely used segmentation algorithms are region based, which mostly rely on the intensity homogeneity, and could bring inaccurate results. In this paper, we propose a novel region-based active contour model in a variationa...
journal_title:Magnetic resonance imaging
pub_type: 杂志文章
doi:10.1016/j.mri.2012.10.010
更新日期:2013-05-01 00:00:00
abstract::NMR offers, in the complex proton relaxation properties of biological tissues, a unique and potentially powerful tool of tissue characterization. The difficulties encountered so far in comparing the results of in vitro and in vivo NMR studies carried out in different laboratories inhibit NMR methodologies from fully e...
journal_title:Magnetic resonance imaging
pub_type: 杂志文章
doi:10.1016/0730-725x(88)90447-x
更新日期:1988-03-01 00:00:00
abstract::The purpose of the study was to determine whether diffusion-weighted magnetic resonance imaging (DWI) could identify focal lesions that develop in ischemia-sensitive cerebral tissues during reperfusion following global brain ischemia. Localized 1H-Magnetic Resonance Spectroscopy (1H-MRS) measurements were also obtaine...
journal_title:Magnetic resonance imaging
pub_type: 杂志文章
doi:10.1016/0730-725x(96)00094-x
更新日期:1996-01-01 00:00:00