Abstract:
:Six dichapetalins named dichapetalins N-S were isolated from Dichapetalum mombuttense, Dichapetalum zenkeri and Dichapetalum leucosia. They were accompanied in the same plants by the known dichapetalins A, B, C, I, L and M. The structures of the compounds were elucidated by 1D and 2D NMR experiments and mass spectrometry. They all possessed the dammarane skeleton substituted at position C-3 by a C6-C2 unit forming a 2-phenylpyran moiety. All contained a lactone ring in the side chain except dichapetalins O, Q and R, in which this ring was replaced by a lactol. Dichapetalin Q and R were also the first dichapetalins bearing a tertiary methyl and a double bond instead of the cyclopropane of the dammaranes. All these compounds were assayed against cancer cell lines HCT116 and WM 266-4 and displayed cytotoxic and anti-proliferative activities in the 10(-6) to 10(-8)M range.
journal_name
Phytochemistryjournal_title
Phytochemistryauthors
Long C,Aussagues Y,Molinier N,Marcourt L,Vendier L,Samson A,Poughon V,Chalo Mutiso PB,Ausseil F,Sautel F,Arimondo PB,Massiot Gdoi
10.1016/j.phytochem.2013.03.023subject
Has Abstractpub_date
2013-10-01 00:00:00pages
184-91eissn
0031-9422issn
1873-3700pii
S0031-9422(13)00120-9journal_volume
94pub_type
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