Dichapetalins from Dichapetalum species and their cytotoxic properties.

Abstract:

:Six dichapetalins named dichapetalins N-S were isolated from Dichapetalum mombuttense, Dichapetalum zenkeri and Dichapetalum leucosia. They were accompanied in the same plants by the known dichapetalins A, B, C, I, L and M. The structures of the compounds were elucidated by 1D and 2D NMR experiments and mass spectrometry. They all possessed the dammarane skeleton substituted at position C-3 by a C6-C2 unit forming a 2-phenylpyran moiety. All contained a lactone ring in the side chain except dichapetalins O, Q and R, in which this ring was replaced by a lactol. Dichapetalin Q and R were also the first dichapetalins bearing a tertiary methyl and a double bond instead of the cyclopropane of the dammaranes. All these compounds were assayed against cancer cell lines HCT116 and WM 266-4 and displayed cytotoxic and anti-proliferative activities in the 10(-6) to 10(-8)M range.

journal_name

Phytochemistry

journal_title

Phytochemistry

authors

Long C,Aussagues Y,Molinier N,Marcourt L,Vendier L,Samson A,Poughon V,Chalo Mutiso PB,Ausseil F,Sautel F,Arimondo PB,Massiot G

doi

10.1016/j.phytochem.2013.03.023

subject

Has Abstract

pub_date

2013-10-01 00:00:00

pages

184-91

eissn

0031-9422

issn

1873-3700

pii

S0031-9422(13)00120-9

journal_volume

94

pub_type

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