Abstract:
:Regulation of hematopoietic stem cell release, migration, and homing from the bone marrow (BM) and of the mobilization pathway involves a complex interaction among adhesion molecules, cytokines, proteolytic enzymes, stromal cells, and hematopoietic cells. The identification of new mechanisms that regulate the trafficking of hematopoietic stem/progenitor cells (HSPCs) cells has important implications, not only for hematopoietic transplantation but also for cell therapies in regenerative medicine for patients with acute myocardial infarction, spinal cord injury, and stroke, among others. This paper reviews the regulation mechanisms underlying the homing and mobilization of BM hematopoietic stem/progenitor cells, investigating the following issues: (a) the role of different factors, such as stromal cell derived factor-1 (SDF-1), granulocyte colony-stimulating factor (G-CSF), and vascular cell adhesion molecule-1 (VCAM-1), among other ligands; (b) the stem cell count in peripheral blood and BM and influential factors; (c) the therapeutic utilization of this phenomenon in lesions in different tissues, examining the agents involved in HSPCs mobilization, such as the different forms of G-CSF, plerixafor, and natalizumab; and (d) the effects of this mobilization on BM-derived stem/progenitor cells in clinical trials of patients with different diseases.
journal_name
Biomed Res Intjournal_title
BioMed research internationalauthors
Alvarez P,Carrillo E,Vélez C,Hita-Contreras F,Martínez-Amat A,Rodríguez-Serrano F,Boulaiz H,Ortiz R,Melguizo C,Prados J,Aránega Adoi
10.1155/2013/312656subject
Has Abstractpub_date
2013-01-01 00:00:00pages
312656eissn
2314-6133issn
2314-6141journal_volume
2013pub_type
杂志文章,评审abstract::DNA methylation primarily occurs on CpG dinucleotides and plays an important role in transcriptional regulations during tissue development and cell differentiation. Over 25% of CpG dinucleotides in the human genome reside within Alu elements, the most abundant human repeats. The methylation of Alu elements is an impor...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2014/784706
更新日期:2014-01-01 00:00:00
abstract::Iran is one of the six countries with the most cutaneous leishmaniasis (CL) patients. Understanding better the genotypes of the parasite population in relation to geography and climate is critical to achieving better CL control. We aimed to characterise the population structure of Leishmania tropica, the cause of anth...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/6049198
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/120802
更新日期:2015-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/764382
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journal_title:BioMed research international
pub_type: 杂志文章
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abstract::Traumatic brain injury (TBI) is a critical public health and socioeconomic problem worldwide. The herb pair Astragali Radix (AR)-Radix Angelica Sinensis (RAS) is a common prescribed herbal formula or is added to other Chinese medicine prescriptions for traumatic brain injury (TBI) treatment. However, the underlying me...
journal_title:BioMed research international
pub_type: 杂志文章
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journal_title:BioMed research international
pub_type: 杂志文章
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更新日期:2020-11-09 00:00:00
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pub_type: 杂志文章
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pub_type: 临床试验,杂志文章
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更新日期:2020-01-02 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/3125842
更新日期:2017-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 临床试验,杂志文章
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更新日期:2016-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章,meta分析
doi:10.1155/2019/2139834
更新日期:2019-11-26 00:00:00
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pub_type: 杂志文章
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更新日期:2014-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1155/2020/2345607
更新日期:2020-08-10 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/569130
更新日期:2014-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/2961767
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pub_type: 杂志文章,评审
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journal_title:BioMed research international
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journal_title:BioMed research international
pub_type: 杂志文章
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更新日期:2016-01-01 00:00:00
abstract::Cellulase from Aspergillus niger was immobilized onto β-cyclodextrin-conjugated magnetic particles by silanization and reductive amidation. The immobilized cellulase gained supermagnetism due to the magnetic nanoparticles. Ninety percent of cellulase was immobilized, but the activity of immobilized cellulase decreased...
journal_title:BioMed research international
pub_type: 杂志文章
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journal_title:BioMed research international
pub_type: 杂志文章,评审
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pub_type: 杂志文章
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journal_title:BioMed research international
pub_type: 杂志文章
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更新日期:2017-01-01 00:00:00
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journal_title:BioMed research international
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更新日期:2017-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1155/2016/2532371
更新日期:2016-01-01 00:00:00