Ornithine transcarbamylase deficiency in spf and spf-ash mice: genes, mRNAs and mRNA precursors.

abstract：:Gastric cancer (GC) is one of the most common cancers and is the second-leading cause of cancer-associated morbidity worldwide. Oxysterols are oxidized derivatives of cholesterol that may be important in many biological processes, but the levels and roles of oxysterols in gastric tumours remain to be elucidated. The l...

journal_title：Biochemical and biophysical research communications

authors： Guo F,Hong W,Yang M,Xu D,Bai Q,Li X,Chen Z

更新日期：2018-10-12 00:00:00

abstract：:HL-60 nuclear autophosphorylation was studied in vitro under circumstances in which the conformation of chromatin was manipulated with both polyamines and DNAse-I. A general re-arrangement of the phosphorylation patterns occurred as polyamines were removed and nuclei were observed to expand. DNAse-I treatment reduced ...

journal_title：Biochemical and biophysical research communications

authors： Testori A,Skinner JD,Murray AW,Burgoyne LA

更新日期：1991-10-15 00:00:00

abstract：:Methylglyoxal (MG), a cytotoxic by-product produced mainly from triose phosphates, is used as a substrate by glyoxalase I. In this paper, we report on the estimation of MG level in plants which has not been reported earlier. We show that MG concentration varies in the range of 30-75 microM in various plant species and...

journal_title：Biochemical and biophysical research communications

authors： Yadav SK,Singla-Pareek SL,Ray M,Reddy MK,Sopory SK

更新日期：2005-11-11 00:00:00

abstract：:Apoaequorin was targeted to the cytosol, nucleus, and endoplasmic reticulum of HeLa cells in order to determine the effect of Ca(2+) release from the ER on protein degradation. In resting cells apoaequorin had a rapid half-life (ca. 20-30 min) in the cytosol or nucleus, but was relatively stable for up to 24 h in the ...

journal_title：Biochemical and biophysical research communications

authors： Jeffery J,Kendall JM,Campbell AK

更新日期：2000-02-24 00:00:00

abstract：:The receptor for calcitonin gene-related peptide (CGRP) has been the target for the development of novel small molecule antagonists for the treatment of migraine. Two such antagonists, BIBN4096BS and MK-0974, have shown great promise in clinical trials and hence a deeper understanding of the mechanism of their interac...

journal_title：Biochemical and biophysical research communications

authors： Miller PS,Barwell J,Poyner DR,Wigglesworth MJ,Garland SL,Donnelly D

更新日期：2010-01-01 00:00:00

abstract：:A fractionation of the membrane extract of rat testes revealed the existence of pp60c-src kinase activity. The expression of pp60c-src was examined in the developing rat testes. The immunecomplex kinase assay using a monoclonal antibody specific to pp60c-src (mAb327) showed that the expression of pp60c-src kinase acti...

journal_title：Biochemical and biophysical research communications

authors： Nishio H,Tokuda M,Itano T,Matsui H,Takeuchi Y,Hatase O

更新日期：1995-01-17 00:00:00

abstract：:A high incidence of oncogenic K-ras mutations is observed in lung adenocarcinoma of human cases and carcinogen-induced animal models. The process of oncogenic K-ras-mediated lung adenocarcinogenesis can be dissected into two parts: pre- and post-K-ras mutation. Adoption of transgenic lines containing a flox-K-rasG12V ...

journal_title：Biochemical and biophysical research communications

authors： Saito H,Suzuki N

更新日期：2014-10-03 00:00:00

abstract：:A calmodulin antagonist, N-(6-aminohexyl)-5-chloro-1-naphthalene-sulfonamide (W-7), reduced the number of phorbol ester receptors in mouse skin in a dose- and time-dependent manner. The reduction occurred immediately after topical application of 30 mumoles of W-7, reaching a maximum of 86% after 5 min. Reduction in sp...

journal_title：Biochemical and biophysical research communications

authors： Nishino H,Fujiki H,Suganuma M,Horiuchi T,Iwashima A,Sugimura T

更新日期：1984-11-14 00:00:00

abstract：:TREK1 is a member of the tandem-P domain K+ channel family which is expressed almost exclusively in the nervous system. It is modulated by a number of important factors including arachidonic acid and cell swelling. Since both factors are associated with brain ischemia, it has been suggested that activation of TREK1 ma...

journal_title：Biochemical and biophysical research communications

authors： Miller P,Kemp PJ,Peers C

更新日期：2005-06-17 00:00:00

abstract：:IGF-I, when added to TSH-primed FRTL-5 cells, induces a long lasting Ca2+ influx and then DNA synthesis. Ca2+ channel agonist, BAYK 8644, is capable to mimic these effects on cell proliferation. We studied the effect of genistein, a specific tyrosine kinase inhibitor, on BAY K8644- or IGF-I- induced cell cycle progres...

journal_title：Biochemical and biophysical research communications

authors： Takano T,Takada K,Tada H,Nishiyama S,Amino N

更新日期：1993-02-15 00:00:00

abstract：:The nucleotide analogue 5-p-fluorosulfonylbenzoyladenosine reacts with rat liver microsomal 3-hydroxy-3-methylglutaryl-CoA reductase kinase, causing a rapid loss of the AMP activation capacity and a slower inactivation of the catalytic activity. The rate constant for loss of AMP activation is eleven times higher (K1 =...

journal_title：Biochemical and biophysical research communications

authors： Ferrer A,Caelles C,Hegardt FG

更新日期：1987-11-13 00:00:00

abstract：:It has been proposed that the inositol 1,4,5-trisphosphate receptor (InsP(3)R) type III acts as a trigger for InsP(3)-mediated calcium (Ca(2+)) signaling, because this InsP(3) isoform lacks feedback inhibition by cytosolic Ca(2+). We tested this hypothesis in RIN-m5F cells, which express predominantly the type III rec...

journal_title：Biochemical and biophysical research communications

authors： O'Neill AF,Hagar RE,Zipfel WR,Nathanson MH,Ehrlich BE

更新日期：2002-06-14 00:00:00

abstract：:In this study terminal cisternae vesicles from rabbit skeletal muscle were fused into planar bilayers and the effect of calmodulin on single Ca2+ release channel currents was investigated. In the presence of 10(-7) and 10(-9) M free [Ca2+], nanomolar concentrations of calmodulin activated the channel by increasing the...

journal_title：Biochemical and biophysical research communications

authors： Buratti R,Prestipino G,Menegazzi P,Treves S,Zorzato F

更新日期：1995-08-24 00:00:00

abstract：:Little is known about the gene structure and mRNA expression of cholecystokinin type-A(CCKA) receptor in animals or in human. By screening an EMBL phage library containing partially digested Long-Evans rat DNA, we isolated 7 genomic clones covering a continuous 27 kb region over which a rat CCKA receptor gene spanned....

journal_title：Biochemical and biophysical research communications

authors： Takata Y,Takiguchi S,Funakoshi A,Kono A

更新日期：1995-08-24 00:00:00

abstract：:3-Hydroxy-3',4'-dimethoxyflavone (HDMF) is a natural chemical product that is not currently regarded as a drug. In our study, we employed glioblastoma cells and cell biology and biochemistry approaches to investigate the potential of HDMF as a natural anticancer therapy option. FACS analysis showed that treatment conc...

journal_title：Biochemical and biophysical research communications

authors： Bae IH,Lee WS,Yun DH,Han YH,Lee JS

更新日期：2014-07-18 00:00:00

abstract：:Two novel subtilisin-like serine proteases (AS-E1 and -E2) that activate prothrombin have been identified in a culture of the fungus Acremonium sp. The enzymes were purified through repeated hydrophobic interaction chromatography. The N-terminal sequences of AS-E1 (34.4 kDa) and AS-E2 (32 kDa) showed high similarity t...

journal_title：Biochemical and biophysical research communications

authors： Liu C,Matsushita Y,Shimizu K,Makimura K,Hasumi K

更新日期：2007-06-22 00:00:00

abstract：:Activation of reactive oxygen and nitrogen species (RONS) by redox-active metal ions has been proposed to contribute to oxidative damage in inflamed tissues. Here, we report a dual-function anti-oxidant conjugate comprising an anti-inflammatory agent (5-aminosalicylic acid) and a chelator with potential as a superoxid...

journal_title：Biochemical and biophysical research communications

authors： Bailey MA,Ingram MJ,Naughton DP

更新日期：2004-05-14 00:00:00

abstract：:The carbocyclic analogue of (E)-5-(2-bromovinyl)-2'-deoxyuridine, C-BVDU, is a very potent and selective anti-herpes-virus compound. In order to synthesize and study the properties of a DNA that contains C-BVDU, the 5'-triphosphate, C-BVDUTP was prepared and evaluated as a potential substrate of the E. coli Klenow DNA...

journal_title：Biochemical and biophysical research communications

authors： Sági J,De Clercq E,Szemzö A,Csárnyi A,Kovács T,Otvös L

更新日期：1987-09-30 00:00:00

abstract：:Immunoglobulin A (IgA) nephropathy is an important cause of end-stage kidney disease (ESKD). Tubulointerstitial inflammation and subsequent fibrosis appear to be a major contributor of the disease progression to ESKD; however, the underlying mechanism is poorly understood. Herein, we report that a unique feature of CY...

journal_title：Biochemical and biophysical research communications

authors： Cui TG,Ichikawa T,Yang M,Dong X,Li J,Cui T

更新日期：2009-12-11 00:00:00

abstract：:Affinity column-purified GABA-benzodiazepine receptor protein from bovine brain was photoaffinity labeled with both [3H]flunitrazepam and [3H]muscimol. Gel electrophoresis in sodium dodecyl sulfate revealed that the benzodiazepine binding site labeled with [3H]flunitrazepam was primarily associated with a major peptid...

journal_title：Biochemical and biophysical research communications

authors： Deng L,Ransom RW,Olsen RW

更新日期：1986-08-14 00:00:00

abstract：:Advanced glycation end products (AGE) are involved in tissue damage and remodeling. This study investigated whether AGE could elicit inflammatory and fibrogenic reactions in fibroblast cell line MRC-5 cells via autocrine production of aldosterone and if nifedipine could block the AGE actions through mineralocorticoid ...

journal_title：Biochemical and biophysical research communications

authors： Matsui T,Takeuchi M,Yamagishi S

更新日期：2010-05-28 00:00:00

abstract：:The aim of this study is to investigate the mechanism underling cardiac dysfunction during sepsis, as well as the possible amelioration of this dysfunction by exogenous carbon monoxide (CO) administration. For this purpose, rats (six-week-old, male, Sprague-Dawley) were administered LPS (15 mg/kg body weight, i.p. 6 h...

journal_title：Biochemical and biophysical research communications

authors： Unuma K,Aki T,Nagano S,Watanabe R,Uemura K

更新日期：2018-01-08 00:00:00

abstract：:We developed a modified method enabling stable MALDI-MS analysis and fluorescent detection of sialyl-compounds. The modification involved the amidation of sialic acid (Neu5Ac) at the position of the carboxyl group using the fluorescent reagent, 2-(2-pyridilamino)ethylamine (PAEA). In this study the following sialyl-co...

journal_title：Biochemical and biophysical research communications

authors： Endo S,Morita M,Ueno M,Maeda T,Terabayashi T

更新日期：2009-01-23 00:00:00

abstract：:microRNA-222 (miR-222) has been shown to initiate the activation of hepatic stellate cells, which plays an important role in the pathogenesis of liver fibrosis. The aim of our study was to evaluate the role of miR-22 in a mouse model of biliary atresia (BA) induced by Rhesus Rotavirus (RRV) infection. New-born Balb/c ...

journal_title：Biochemical and biophysical research communications

authors： Shen WJ,Dong R,Chen G,Zheng S

更新日期：2014-03-28 00:00:00

abstract：:Deoxyribozymes or DNAzyme are identified as catalytic DNA sequences which catalyze different chemical reactions. Ligating deoxyribozymes catalyze the formation of branched and linear products. Due to the lack of efficient read-out systems, there is no report on in vivo application of ligating deoxyribozymes. To expand...

journal_title：Biochemical and biophysical research communications

authors： Dehghanian F,Najafi ZB,Hojati Z,Javadi-Zarnaghi F

更新日期：2020-04-02 00:00:00

abstract：:This study describes the purification and characterization of an aminopeptidase from human cerebrospinal fluid capable of degrading delta-sleep-inducing-peptide (DSIP). The enzyme has an apparent molecular weight of approximately 80,000 dalton. It is sensitive towards amastatin, bestatin and EDTA and is optimally acti...

journal_title：Biochemical and biophysical research communications

authors： Nyberg F,Thörnwall M,Hetta J

更新日期：1990-03-30 00:00:00

abstract：:Low molecular weight-PTP has been reported as a redox-sensitive protein during both platelet-derived growth factor and integrin signalling. In response to oxidation the phosphatase undergoes a reversible inactivation, which in turn leads to the increase in tyrosine phosphorylation of its substrates and the properly ex...

journal_title：Biochemical and biophysical research communications

authors： Giannoni E,Raugei G,Chiarugi P,Ramponi G

更新日期：2006-09-22 00:00:00

abstract：:Transcription factors belonging to the CCAAT-enhancer binding protein (C/EBP) family have been implicated in the regulation of gene expression during growth, differentiation, apoptosis, and inflammation. Autoregulation is relatively common in the modulation of C/EBP gene expression and, for the human and murine C/EBPa...

journal_title：Biochemical and biophysical research communications

authors： Davies GE,Sabatakos G,Cryer A,Ramji DP

更新日期：2000-05-10 00:00:00

abstract：:Apoptin, a small protein encoded by chicken anemia virus (CAV), induces cell death specifically in cancer cells. In normal cells, Apoptin remains in the cytoplasm; whereas in cancerous cells, it migrates into the nucleus and kills the cell. Cellular localization appears to be crucial. Through a yeast two-hybrid screen...

journal_title：Biochemical and biophysical research communications

authors： Huo DH,Yi LN,Yang J

更新日期：2008-07-18 00:00:00

abstract：:P1-(adenosine-5')-P3-(glucose-6)-triphosphate (Ap3glucose) is a linear uncompetitive inhibitor vs glucose and a linear mixed inhibitor vs ATP of brain hexokinase, an inhibition pattern inconsistent with binding of Ap3glucose to the catalytic site when either the rapid equilibrium random or ordered sequential mechanism...

journal_title：Biochemical and biophysical research communications

authors： Manning TA,Wilson JE

更新日期：1984-01-13 00:00:00