Abstract：
AIM:We aimed to define the etiologic and prognostic factors in live-born infants with hydrops fetalis (HF) in our tertiary neonatal intensive care unit over a 10-year period. METHODS:Medical records of newborn infants with HF during 2002-2011 were reviewed retrospectively. Demographic data, prenatal interventions, clinical and laboratory findings, outcomes, and the results of postmortem examinations were analyzed. RESULTS:During the study period, 62 newborn infants with HF were identified from 16,200 live-born deliveries and the incidence of HF was 3.8/1000 live births in our hospital. Twenty-eight infants (45.2%) had immune HF, whereas 34 (54.8%) had nonimmune HF. An etiologic factor could be identified in 24 (70.5%) infants with nonimmune HF. Lymphatic dysplasias comprised the majority (23.5%) of the infants with nonimmune HF. Mortality rate was 50%. The presence of two or more serous cavity effusions and gestational age were independently associated with the risk of mortality. CONCLUSION:Despite the improvements in neonatal care, mortality rate in infants with HF is still high. Gestational age and the extent of serous cavity determine the risk of mortality. Timely and advanced prenatal or postnatal new therapeutic strategies may alter this fatal outcome in appropriate patients.
journal_name
Pediatr Neonatoljournal_title
Pediatrics and neonatologyauthors
Takci S,Gharibzadeh M,Yurdakok M,Ozyuncu O,Korkmaz A,Akcoren Z,Yigit Sdoi
10.1016/j.pedneo.2013.07.008subject
Has Abstractpub_date
2014-04-01 00:00:00pages
108-13issue
2eissn
1875-9572issn
2212-1692pii
S1875-9572(13)00141-1journal_volume
55pub_type
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