Abstract:
BACKGROUND:Non-viral limbic encephalitis, which may be paraneoplastic or idiopathic, is increasingly recognized in adults and children. Early identification of potential patients, who have neuronal autoantibodies to intracellular or neuronal surface antigens in order to give appropriate immunotherapy, is key to improving the prognosis. This cross-sectional study describes the clinical manifestation and the serological evidence of the presence of neuronal antibodies in Taiwanese children with limbic encephalitis. METHOD:We enrolled children and adolescents who had been hospitalized due to nonviral limbic encephalitis. Serum samples from these patients were collected to screen antibodies against intracellular antigens [amphiphysin, Ma2, Ri, Yo, Hu and antiglutamic acid decarboxylase (GAD)] and neuronal surface antigens [N-methyl-d-aspartate (NMDA) receptor, γ-amino butyric acid (GABAB) receptor and voltage-gated potassium channel complexes (VGKCs)]. RESULTS:All of the 10 enrolled patients had acute onset of fever and rapid clinical deterioration. They had persistent neuropsychiatric symptoms and 90% developed refractory epilepsy, despite six patients having been treated with methylprednisolone pulse therapy or intravenous immunoglobulin (IVIG) at the acute stage. In the laboratory findings, half of the cases were positive for antibodies with regards to intracellular antigens (amphiphysin or GAD). The general outcomes, assessed by Glasgow Outcome Scale, were similar between patients with and those without the antibodies (Mann-Whitney U test, p = 0.43). One patient, who was positive for antibodies to amphiphysin 10 years after disease onset, still had a significant response to oral prednisolone therapy. At the end of the follow-up period, no cancer or insulin-dependent diabetes mellitus was detected in any of the patients. CONCLUSION:This study provides evidence for a potential association between antibodies and limbic encephalitis. The presence of antibodies, especially antibodies to GAD, may serve as an indicator for immunotherapy.
journal_name
Pediatr Neonatoljournal_title
Pediatrics and neonatologyauthors
Chou IJ,Wang HS,Lin JJ,Kuo CF,Lin KL,Chou ML,Hung PC,Hsieh MY,Lin YT,CHEESE Study Group.doi
10.1016/j.pedneo.2013.01.016subject
Has Abstractpub_date
2013-08-01 00:00:00pages
246-53issue
4eissn
1875-9572issn
2212-1692pii
S1875-9572(13)00017-Xjournal_volume
54pub_type
杂志文章abstract:BACKGROUND:Screening for infectious diseases in newborns using immunoglobulin (Ig)A-, IgM-, and IgE-specific antibodies is expensive and impractical. To determine if total levels of these Igs can be used for screening purposes, thus simplifying the process, their basic levels in the 1(st) month of extrauterine life nee...
journal_title:Pediatrics and neonatology
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更新日期:2016-06-01 00:00:00
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journal_title:Pediatrics and neonatology
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journal_title:Pediatrics and neonatology
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journal_title:Pediatrics and neonatology
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journal_title:Pediatrics and neonatology
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journal_title:Pediatrics and neonatology
pub_type: 杂志文章,评审
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更新日期:2016-12-01 00:00:00
abstract:BACKGROUND:Most small muscular ventricular septal defect (M-VSD) types have been diagnosed using color Doppler echocardiography. The purpose of this study was to understand the incidence of small M-VSD in the neonatal period and analyze the natural history of these M-VSDs. MATERIALS AND METHODS:All individuals in our ...
journal_title:Pediatrics and neonatology
pub_type: 杂志文章
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更新日期:2011-10-01 00:00:00
abstract::Head trauma is one of the most challenging fields of traumatology and demands immediate attention and intervention by first-line clinicians. Symptoms can vary from victim to victim and according to the victim's age, leading to difficulties in making timely and accurate decisions at the point of care. In children, fall...
journal_title:Pediatrics and neonatology
pub_type: 杂志文章,评审
doi:10.1016/j.pedneo.2012.12.011
更新日期:2013-04-01 00:00:00
abstract:AIM:We aimed to define the etiologic and prognostic factors in live-born infants with hydrops fetalis (HF) in our tertiary neonatal intensive care unit over a 10-year period. METHODS:Medical records of newborn infants with HF during 2002-2011 were reviewed retrospectively. Demographic data, prenatal interventions, cli...
journal_title:Pediatrics and neonatology
pub_type: 杂志文章
doi:10.1016/j.pedneo.2013.07.008
更新日期:2014-04-01 00:00:00
abstract:BACKGROUND:There are few reports on the symptoms of rotavirus infections in neonates. This study aims to describe clinical signs of rotavirus infections among neonates, with a particular focus on preterm infants, and to show the distribution of genotypes in a neonatal intensive care unit (NICU). METHODS:A prospective ...
journal_title:Pediatrics and neonatology
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abstract::The recent introduction of different non-invasive ventilation modes for preterm has decreased the need for intubation, invasive ventilation and sedation. However, specific guidelines for each non-invasive mode are still lacking. This paper reviews available evidence for each of the commonly used noninvasive mode. Elec...
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journal_title:Pediatrics and neonatology
pub_type: 杂志文章
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journal_title:Pediatrics and neonatology
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journal_title:Pediatrics and neonatology
pub_type: 杂志文章
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更新日期:2010-04-01 00:00:00
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journal_title:Pediatrics and neonatology
pub_type: 杂志文章
doi:10.1016/j.pedneo.2012.07.002
更新日期:2012-10-01 00:00:00
abstract:BACKGROUND:Meconium peritonitis (MP) develops when bowel perforation occurs in utero or soon after birth, resulting in leakage of meconium into the peritoneal cavity. The clinical features are often variable and prenatal ultrasonography plays an important role in prenatal diagnosis. METHODS:We conducted a retrospectiv...
journal_title:Pediatrics and neonatology
pub_type: 杂志文章
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更新日期:2009-04-01 00:00:00
abstract:BACKGROUND:We aimed to study the changes of serum N-terminal pro-brain natriuretic to peptide (NT-proBNP) levels after asphyxia-induced myocardial injury in children and explore the relationship between serum NT-proBNP levels and neonatal asphyxia. METHODS:One hundred and six cases of neonatal asphyxia were randomly s...
journal_title:Pediatrics and neonatology
pub_type: 杂志文章
doi:10.1016/j.pedneo.2015.08.001
更新日期:2016-04-01 00:00:00
abstract:BACKGROUND:To assess the safety and efficacy of oral propranolol in the management of periocular Capillary Hemangiomas of Infancy (CHI). METHODS:Medical records of 21 infants diagnosed with periocular capillary hemangioma during a period of 5 years from 2009 to 2014 were retrospectively reviewed. The data collected in...
journal_title:Pediatrics and neonatology
pub_type: 杂志文章
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更新日期:2018-08-01 00:00:00
abstract:BACKGROUND:Rankings of infant mortality rates are commonly cited international comparisons to assess the health status of individual countries. We compared the infant mortality rate of Taiwan with those of European countries for 2004 according to two definitions. METHODS:First, the countries were ranked on the basis o...
journal_title:Pediatrics and neonatology
pub_type: 杂志文章
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更新日期:2016-08-01 00:00:00
abstract:BACKGROUND:Esophageal atresia (EA) with or without tracheoesophageal fistula (TEF) remains one of the most common gastrointestinal neonatal malformations. Even though postoperative management is standardized, it differs between hospitals and disease-associated clinical factors that may play a role in outcome have not y...
journal_title:Pediatrics and neonatology
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更新日期:2021-01-01 00:00:00
abstract:BACKGROUND:Lenticulostriate vasculopathy is associated with various disorders, in particular cytomegalovirus infection, which can cause neurological consequences. We wanted to evaluate the association of lenticulostriate vasculopathy and cytomegalovirus infection. We retrospectively collected data on lenticulostriate v...
journal_title:Pediatrics and neonatology
pub_type: 杂志文章
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更新日期:2015-12-01 00:00:00
abstract::Recently, heated humidified high-flow nasal cannula (HHHFNC) has been introduced and applied as a noninvasive respiratory support in neonates. Although HHHFNC is widely used in neonates presenting with respiratory distress, the efficiency and safety when compared with nasal continuous positive airway pressure or nonin...
journal_title:Pediatrics and neonatology
pub_type: 杂志文章,评审
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更新日期:2017-08-01 00:00:00