Abstract：
BACKGROUND:To examine whether polymorphisms in the VEGFA gene lead to low VEGFA production in peripheral blood and increased risk of NEC in the Chinese Han population. MATERIAL AND METHODS:Thirty NEC patients and 80 control subjects were enrolled. Six VEGFA single-nucleotide polymorphisms (SNPs) were performed using the SEQUENOM MassARRAY platform assay. The concentration of VEGFA in the plasma was measured using an enzyme-linked immunosorbent assay. RESULTS:The rs699947 and rs833061 VEGF-A SNPs were found to be associated with low plasma levels and high risk of NEC. CONCLUSION:Our results suggested that, if validated in larger studies, screening for VEGFA SNPs and plasma levels might be useful as a risk factor for NEC in the future.
journal_name
Pediatr Neonatoljournal_title
Pediatrics and neonatologyauthors
Gao X,Ma F,Hao H,Dai Y,Liu W,Xiao X,Gao P,Li Sdoi
10.1016/j.pedneo.2018.07.002subject
Has Abstractpub_date
2019-04-01 00:00:00pages
129-134issue
2eissn
1875-9572issn
2212-1692pii
S1875-9572(17)30803-3journal_volume
60pub_type
杂志文章,评审abstract：:Therapeutic hypothermia (TH) is a recommended regimen for newborn infants who are at or near term with evolving moderate-to-severe hypoxic ischemic encephalopathy (HIE). The Task Force of the Taiwan Child Neurology Society and the Taiwan Society of Neonatology held a joint meeting in 2015 to establish recommendations ...
journal_title：Pediatrics and neonatology
pub_type： 杂志文章,评审
doi：10.1016/j.pedneo.2016.11.001
更新日期：2017-12-01 00:00:00
abstract：PURPOSE:To investigate parents' views about new vaccines, we surveyed the attitudes and awareness toward immunization program among parents of children younger than 14 years in Taiwan. METHODS:Parents of children were invited to complete a questionnaire in a tertiary referral medical center in Kaoshiung, southern Taiw...
journal_title：Pediatrics and neonatology
pub_type： 杂志文章
doi：10.1016/j.pedneo.2011.02.009
更新日期：2011-04-01 00:00:00
abstract：BACKGROUND:The gastroesophageal reflux disease (GERD) questionnaire (GerdQ) is a validated questionnaire that was developed recently to help identify GERD patients. The sensitivity and specificity of GerdQ for the diagnosis of GERD in adult patients were 65% and 71%, respectively. Because the application of GerdQ in pe...
journal_title：Pediatrics and neonatology
pub_type： 杂志文章
doi：10.1016/j.pedneo.2014.01.004
更新日期：2014-12-01 00:00:00
abstract：:An otherwise healthy female baby who had received early postnatal antibiotic prophylaxis because of maternal vaginal group B streptococcal (GBS) colonization died of late-onset GBS meningitis. GBS was isolated from blood and cerebrospinal fluid. Genotyping using pulsed-field gel electrophoresis confirmed that the GBS ...
journal_title：Pediatrics and neonatology
pub_type： 杂志文章
doi：10.1016/S1875-9572(10)60046-0
更新日期：2010-08-01 00:00:00
abstract：:Internal herniation is a rare cause of intestinal obstruction, especially in the emergency department. We report a child with acute abdomen resulting from transmesenteric internal herniation of the small bowel. Radiographic findings revealed gaseous distension of the bowel loops in the upper abdominal area with a pauc...
journal_title：Pediatrics and neonatology
pub_type： 杂志文章
doi：10.1016/j.pedneo.2012.12.008
更新日期：2014-04-01 00:00:00
abstract：:Multicystic dysplastic kidney (MCDK) is a congenital maldevelopment in which the renal cortex is characteristically replaced by numerous cysts of multiple sizes. MCDK presenting as a single predominant large cyst in morphology is less common. We report on the prenatal imaging findings and perinatal management of a fet...
journal_title：Pediatrics and neonatology
pub_type： 杂志文章
doi：10.1016/j.pedneo.2011.05.009
更新日期：2011-08-01 00:00:00
abstract：BACKGROUND:To assess the safety and efficacy of oral propranolol in the management of periocular Capillary Hemangiomas of Infancy (CHI). METHODS:Medical records of 21 infants diagnosed with periocular capillary hemangioma during a period of 5 years from 2009 to 2014 were retrospectively reviewed. The data collected in...
journal_title：Pediatrics and neonatology
pub_type： 杂志文章
doi：10.1016/j.pedneo.2017.11.021
更新日期：2018-08-01 00:00:00
abstract：:Hepatic veno-occlusive disease (VOD), also called sinusoidal obstruction syndrome, is rapidly progressing and involves life-threatening complications that can occur in patients receiving chemotherapy and/or bone marrow transplantation. No completely satisfactory treatmentstrategies have yet been established. We presen...
journal_title：Pediatrics and neonatology
pub_type： 杂志文章
doi：10.1016/S1875-9572(08)60029-7
更新日期：2008-08-01 00:00:00
abstract：:The recent introduction of different non-invasive ventilation modes for preterm has decreased the need for intubation, invasive ventilation and sedation. However, specific guidelines for each non-invasive mode are still lacking. This paper reviews available evidence for each of the commonly used noninvasive mode. Elec...
journal_title：Pediatrics and neonatology
pub_type： 杂志文章,评审
doi：10.1016/j.pedneo.2019.09.014
更新日期：2020-04-01 00:00:00
abstract：BACKGROUND:The most severe form of pneumococcal disease is invasive pneumococcal disease (IPD), including empyema, sepsis and meningitis. Thomsen-Friedenreich antigen (TA; Galβ1-3GalNAc) activation is known to be a predictor of Streptococcus pneumoniae-associated hemolytic uremic syndrome (Sp-HUS). There have been limi...
journal_title：Pediatrics and neonatology
pub_type： 杂志文章
doi：10.1016/j.pedneo.2020.02.005
更新日期：2020-06-01 00:00:00
abstract：BACKGROUND:Circulatory collapse is a very common complication of the critical illnesses in neonates including neonates with hypoxic ischemic encephalopathy; it can be the end result and cause of death of several conditions. Often, despite treatment with fluid resuscitation and vasopressor agents, circulatory collapse p...
journal_title：Pediatrics and neonatology
pub_type： 杂志文章
doi：10.1016/j.pedneo.2016.09.010
更新日期：2017-12-01 00:00:00
abstract：BACKGROUND:There are few reports on the symptoms of rotavirus infections in neonates. This study aims to describe clinical signs of rotavirus infections among neonates, with a particular focus on preterm infants, and to show the distribution of genotypes in a neonatal intensive care unit (NICU). METHODS:A prospective ...
journal_title：Pediatrics and neonatology
pub_type： 杂志文章
doi：10.1016/j.pedneo.2011.11.005
更新日期：2012-02-01 00:00:00
abstract：BACKGROUND:Asthma is a chronic inflammatory disease of the airways for which current treatments are mainly based on pharmacological interventions, such as glucocorticoid therapy. Our objective was to study the immunoregulatory effects of caffeic acid phenethyl ester (CAPE, a phytochemical synthesized from propolis) on ...
journal_title：Pediatrics and neonatology
pub_type： 杂志文章
doi：10.1016/j.pedneo.2011.08.005
更新日期：2011-12-01 00:00:00
abstract：BACKGROUND:There is limited evidence of the effect of positive end-expiratory pressure (PEEP) during resuscitation soon after birth. Premature neonates may experience respiratory distress from surfactant insufficiency and providing PEEP after the very first breath, may improve outcomes following appropriate resuscitati...
journal_title：Pediatrics and neonatology
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.pedneo.2017.12.002
更新日期：2018-10-01 00:00:00
abstract：BACKGROUND:Pediatric glioblastoma is a malignant disease with an extremely poor clinical outcome. Patients usually suffer from resistance to radiation therapy, so targeted drug treatment may be a new possibility for glioblastoma therapy. Survivin is also overexpressed in glioblastoma. YM155, a novel small-molecule surv...
journal_title：Pediatrics and neonatology
pub_type： 杂志文章
doi：10.1016/j.pedneo.2012.04.008
更新日期：2012-06-01 00:00:00
abstract：:Congenital central hypoventilation syndrome (CCHS) is a rare condition. The main characteristic is respiratory insufficiency during sleep. Patients who have CCHS need varying degrees of ventilation support during sleep, or even all day long, according to its severity. We report a term baby with repeated extubation fai...
journal_title：Pediatrics and neonatology
pub_type： 杂志文章
doi：10.1016/j.pedneo.2011.11.015
更新日期：2012-02-01 00:00:00
abstract：BACKGROUND:Zellweger syndrome (ZS) is a peroxisome biogenesis disorder attributed to a mutation of the PEX genes family. The incidence of this disease in Africa and the Arab world remains unknown. This contribution is aimed at describing the clinical phenotype and biochemical features in Tunisian patients with ZS in or...
journal_title：Pediatrics and neonatology
pub_type： 杂志文章
doi：10.1016/j.pedneo.2016.08.011
更新日期：2017-12-01 00:00:00
abstract：BACKGROUND:Birth size can affect neonatal morbidity and mortality. The insulin-like growth factor (IGF) system is the most important endocrine factor influencing fetal growth. In the circulation, IGFs (mostly IGF-I) are bound to IGF-binding protein 3 (IGFBP-3) and an acid-labile subunit (ALS) to form a ternary complex....
journal_title：Pediatrics and neonatology
pub_type： 杂志文章
doi：10.1016/j.pedneo.2013.09.002
更新日期：2014-04-01 00:00:00
abstract：:Juvenile myelomonocytic leukemia (JMML) is a rare hematologic malignancy in children. Its presentations include anemia, thrombocytopenia, monocytosis, skin rash, marked hepatomegaly, and/or splenomegaly. Fever and respiratory involvement are common. Here, we report a case of a premature neonate with initial symptoms o...
journal_title：Pediatrics and neonatology
pub_type： 杂志文章
doi：10.1016/j.pedneo.2013.06.009
更新日期：2016-04-01 00:00:00
abstract：BACKGROUND:Undernourished children who require hospital care have a longer duration of hospitalization and respond poorly to modern medical therapy. The objective of the present study was to ascertain the nutritional status of children admitted to a pediatric tertiary center in Malaysia and the risk factors leading to ...
journal_title：Pediatrics and neonatology
pub_type： 杂志文章
doi：10.1016/j.pedneo.2016.08.010
更新日期：2017-10-01 00:00:00
abstract：BACKGROUND:Non-viral limbic encephalitis, which may be paraneoplastic or idiopathic, is increasingly recognized in adults and children. Early identification of potential patients, who have neuronal autoantibodies to intracellular or neuronal surface antigens in order to give appropriate immunotherapy, is key to improvi...
journal_title：Pediatrics and neonatology
pub_type： 杂志文章
doi：10.1016/j.pedneo.2013.01.016
更新日期：2013-08-01 00:00:00
abstract：BACKGROUND:Despite advances in therapeutic modalities, congenital diaphragmatic hernia (CDH) still accounts for significant neonatal mortality. This study aimed to describe the demographic features, clinical experiences of postnatal care, and differences between non-survivors and survivors with CDH. METHODS:We retrosp...
journal_title：Pediatrics and neonatology
pub_type： 杂志文章
doi：10.1016/S1875-9572(10)60018-6
更新日期：2010-04-01 00:00:00
abstract：BACKGROUND:The diagnosis of neonatal sepsis still considered to be a challenge for both clinicians and the laboratory due to the non-specific clinical presentations. The present study aimed to compare and assess the diagnostic & prognostic values of C-reactive protein (CRP), high sensitivity CRP (hsCRP), presepsin, int...
journal_title：Pediatrics and neonatology
pub_type： 杂志文章
doi：10.1016/j.pedneo.2018.05.001
更新日期：2019-04-01 00:00:00
abstract：:Head trauma is one of the most challenging fields of traumatology and demands immediate attention and intervention by first-line clinicians. Symptoms can vary from victim to victim and according to the victim's age, leading to difficulties in making timely and accurate decisions at the point of care. In children, fall...
journal_title：Pediatrics and neonatology
pub_type： 杂志文章,评审
doi：10.1016/j.pedneo.2012.12.011
更新日期：2013-04-01 00:00:00
abstract：BACKGROUND:The study of genetic polymorphisms of surfactant-lipids related genes can help to understand individual variability in the susceptibility to development of pulmonary pathologies. The purpose of this study was to evaluate the association of polymorphisms of surfactant-lipids related genes (LPCAT1, CHPT1 and P...
journal_title：Pediatrics and neonatology
pub_type： 杂志文章
doi：10.1016/j.pedneo.2019.12.012
更新日期：2020-06-01 00:00:00
abstract：BACKGROUND:To compare outcomes of extremely low birth weight (ELBW) infants having different weight losses in the first 3 days of life. METHODS:One hundred and twenty six ELBW infants were evaluated retrospectively for weight loss percentages on the third day of life compared to their birth weight. We examined the wei...
journal_title：Pediatrics and neonatology
pub_type： 杂志文章
doi：10.1016/j.pedneo.2018.06.003
更新日期：2019-04-01 00:00:00
abstract：:Methanol poisoning is rare in the pediatric population, but a delay in diagnosis and intervention may cause severe morbidity and mortality. The current therapy for methanol poisoning is ethanol or fomepizole, which acts as a competitive inhibitor of hepatic alcohol dehydrogenase to inhibit the production of toxic meta...
journal_title：Pediatrics and neonatology
pub_type： 杂志文章,评审
doi：10.1016/j.pedneo.2013.08.009
更新日期：2016-08-01 00:00:00
abstract：BACKGROUND:Most small muscular ventricular septal defect (M-VSD) types have been diagnosed using color Doppler echocardiography. The purpose of this study was to understand the incidence of small M-VSD in the neonatal period and analyze the natural history of these M-VSDs. MATERIALS AND METHODS:All individuals in our ...
journal_title：Pediatrics and neonatology
pub_type： 杂志文章
doi：10.1016/j.pedneo.2011.06.003
更新日期：2011-10-01 00:00:00
abstract：BACKGROUND:Neonatal sepsis contributes to great mortality and morbidity among very-low-birth-weight (VLBW) infants. Prevalence and pathogen distribution of sepsis in the neonatal intensive care units (NICUs) vary with time and geographic location. Such information serves as a guide for selection of empirical antibiotic...
journal_title：Pediatrics and neonatology
pub_type： 杂志文章
doi：10.1016/j.pedneo.2012.06.003
更新日期：2012-08-01 00:00:00
abstract：BACKGROUND:Hypoglycemia is common in neonates and may cause adverse neurological outcomes. Guidelines should aim to prevent repeated hypoglycemic episodes in risk groups, but they are not usually stratified according to the severity of hypoglycemia risk, which may lead to inappropriate and redundant interventions. We e...
journal_title：Pediatrics and neonatology
pub_type： 杂志文章
doi：10.1016/j.pedneo.2016.12.002
更新日期：2017-10-01 00:00:00
