Use of Fomepizole in Pediatric Methanol Exposure: The First Case Report in Taiwan and a Literature Review.

Abstract:

:Methanol poisoning is rare in the pediatric population, but a delay in diagnosis and intervention may cause severe morbidity and mortality. The current therapy for methanol poisoning is ethanol or fomepizole, which acts as a competitive inhibitor of hepatic alcohol dehydrogenase to inhibit the production of toxic metabolites derived from the oxidation of methanol. However, clinical experience in pediatric methanol poisoning is limited, and the safety profiles of the antidotes have not been established in children, especially in Asian populations. This is the first case to describe the use of fomepizole in a child with methanol exposure in Taiwan.

journal_name

Pediatr Neonatol

authors

Chen TH,Kuo CH,Huang CT,Wang WL

doi

10.1016/j.pedneo.2013.08.009

subject

Has Abstract

pub_date

2016-08-01 00:00:00

pages

351-4

issue

4

eissn

1875-9572

issn

2212-1692

pii

S1875-9572(13)00192-7

journal_volume

57

pub_type

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