Abstract:
BACKGROUND:Human metapneumovirus (HMPV) is a recently discovered respiratory pathogen of the family Paramyxoviridae, the same family as that of respiratory syncytial virus (RSV). Premature children are at high risk of severe RSV infections, however, it is unclear whether HMPV infection is more severe in hospitalized children with a history of severe prematurity. METHODS:We conducted a retrospective analysis of the clinical respiratory presentation of all polymerase chain reaction-confirmed HMPV infections in preschool-age children (≤5 years) with and without history of severe prematurity (<32 weeks gestation). Respiratory distress scores were developed to examine the clinical severity of HMPV infections. Demographic and clinical variables were obtained from reviewing electronic medical records. RESULTS:A total of 571 preschool children were identified using polymerase chain reaction-confirmed viral respiratory tract infection during the study period. HMPV was identified as a causative organism in 63 cases (11%). Fifty-eight (n = 58) preschool-age children with HMPV infection were included in this study after excluding those with significant comorbidities. Our data demonstrated that 32.7% of children admitted with HMPV had a history of severe prematurity. Preschool children with a history of prematurity had more severe HMPV disease as illustrated by longer hospitalizations, new or increased need for supplemental O2, and higher severity scores independently of age, ethnicity, and history of asthma. CONCLUSION:Our study suggests that HMPV infection causes significant disease burden among preschool children with a history of prematurity leading to severe respiratory infections and increasing health care resource utilization due to prolonged hospitalizations.
journal_name
Pediatr Neonatoljournal_title
Pediatrics and neonatologyauthors
Pancham K,Sami I,Perez GF,Huseni S,Kurdi B,Rose MC,Rodriguez-Martinez CE,Nino Gdoi
10.1016/j.pedneo.2015.03.008subject
Has Abstractpub_date
2016-02-01 00:00:00pages
27-34issue
1eissn
1875-9572issn
2212-1692pii
S1875-9572(15)00062-5journal_volume
57pub_type
杂志文章abstract::Head trauma is one of the most challenging fields of traumatology and demands immediate attention and intervention by first-line clinicians. Symptoms can vary from victim to victim and according to the victim's age, leading to difficulties in making timely and accurate decisions at the point of care. In children, fall...
journal_title:Pediatrics and neonatology
pub_type: 杂志文章,评审
doi:10.1016/j.pedneo.2012.12.011
更新日期:2013-04-01 00:00:00
abstract:BACKGROUND:Airway remodeling refers to the structural changes in the airways of asthma. Caveolin-1 reduces cell growth and negatively regulates smooth muscle cell proliferation. The aim was to investigate lung caveolin-1 status in a murine model of acute allergic airway disease. METHODS:Six- to eight-week-old female B...
journal_title:Pediatrics and neonatology
pub_type: 杂志文章
doi:10.1016/j.pedneo.2010.12.006
更新日期:2011-02-01 00:00:00
abstract:BACKGROUND:To evaluate the occurrence of constipation after anorectal malformations (ARM) repair and the results of laxative treatment. METHODS:Between August 2012 and July 2017, the clinical data of patients with ARMs was prospectively collected. The patients were divided into two groups, good types and poor types. G...
journal_title:Pediatrics and neonatology
pub_type: 杂志文章
doi:10.1016/j.pedneo.2019.05.010
更新日期:2020-02-01 00:00:00
abstract:BACKGROUND:The survival of children with malignant germ cell tumor (GCT) increased over the past 2 decades with platinum-based chemotherapy. This report has three objectives: (1) comparison of PVB (cisplatin, vinblastine, and bleomycin) with JEB (carboplatin, etoposide, and bleomycin) regimens; (2) treatment modality o...
journal_title:Pediatrics and neonatology
pub_type: 杂志文章
doi:10.1016/j.pedneo.2014.12.003
更新日期:2015-10-01 00:00:00
abstract::Juvenile myelomonocytic leukemia (JMML) is a rare hematologic malignancy in children. Its presentations include anemia, thrombocytopenia, monocytosis, skin rash, marked hepatomegaly, and/or splenomegaly. Fever and respiratory involvement are common. Here, we report a case of a premature neonate with initial symptoms o...
journal_title:Pediatrics and neonatology
pub_type: 杂志文章
doi:10.1016/j.pedneo.2013.06.009
更新日期:2016-04-01 00:00:00
abstract:BACKGROUND:Development of mediastinal masses after completion of chemotherapy in pediatric patients with malignant lymphoma is worrisome and challenging to clinicians. METHODS:We performed a retrospective review of 67 patients with lymphoma treated at our hospital from January 1, 2001 to June 1, 2013. Patients who rec...
journal_title:Pediatrics and neonatology
pub_type: 杂志文章
doi:10.1016/j.pedneo.2016.02.007
更新日期:2017-04-01 00:00:00
abstract:BACKGROUND:Persistent pulmonary hypertension of the newborn (PPHN) contributes to neonatal hypoxemia and is associated with a high mortality. Some PPHN patients are unresponsive to inhaled nitric oxide (iNO). Bosentan, an oral endothelin-1 receptor antagonist, reduces pulmonary vascular resistance and hence may play a ...
journal_title:Pediatrics and neonatology
pub_type: 杂志文章
doi:10.1016/j.pedneo.2017.02.003
更新日期:2018-02-01 00:00:00
abstract:BACKGROUND:Nonketotic hyperglycinemia (NKH) is a rare, inherited disease, with very poor outcome. It is difficult to confirm the diagnosis due to nonspecific presentations and rapid progression. The incidence was reported in a few countries. We report the clinical and genetic features of typical neonatal NKH with novel...
journal_title:Pediatrics and neonatology
pub_type: 杂志文章
doi:10.1016/j.pedneo.2015.10.008
更新日期:2016-10-01 00:00:00
abstract:BACKGROUND:This study identified factors associated with the recurrence of appendicitis in children with appendiceal masses after successful nonsurgical treatment. METHODS:In this retrospective study, children who were diagnosed as having appendiceal masses after undergoing conservative treatment between 2000 and 2014...
journal_title:Pediatrics and neonatology
pub_type: 杂志文章
doi:10.1016/j.pedneo.2016.12.001
更新日期:2017-08-01 00:00:00
abstract::Glycogen storage disease (GSD) type Ib is caused by the deficiency of glucose-6-phosphate translocase activity. The elder brother of the proband died at age 20 months, and GSD Ia, a disease caused by the deficiency of glucose-6-phosphatase, was the diagnosis. Theproband developed hypoglycemia shortly after birth. Diet...
journal_title:Pediatrics and neonatology
pub_type: 杂志文章
doi:10.1016/S1875-9572(09)60048-6
更新日期:2009-06-01 00:00:00
abstract:BACKGROUND:To analyze predictive factors suggesting transient congenital hypothyroidism (TCH) compared to permanent congenital hypothyroidism (PCH) or transient thyroid function test (TFT) abnormalities among children who had positive screening results at our centers over the past decade. METHODS:A retrospective chart...
journal_title:Pediatrics and neonatology
pub_type: 杂志文章
doi:10.1016/j.pedneo.2017.01.002
更新日期:2017-10-01 00:00:00
abstract:BACKGROUND:We aimed to study the changes of serum N-terminal pro-brain natriuretic to peptide (NT-proBNP) levels after asphyxia-induced myocardial injury in children and explore the relationship between serum NT-proBNP levels and neonatal asphyxia. METHODS:One hundred and six cases of neonatal asphyxia were randomly s...
journal_title:Pediatrics and neonatology
pub_type: 杂志文章
doi:10.1016/j.pedneo.2015.08.001
更新日期:2016-04-01 00:00:00
abstract::Methanol poisoning is rare in the pediatric population, but a delay in diagnosis and intervention may cause severe morbidity and mortality. The current therapy for methanol poisoning is ethanol or fomepizole, which acts as a competitive inhibitor of hepatic alcohol dehydrogenase to inhibit the production of toxic meta...
journal_title:Pediatrics and neonatology
pub_type: 杂志文章,评审
doi:10.1016/j.pedneo.2013.08.009
更新日期:2016-08-01 00:00:00
abstract::Pediatric intensive care is now a subspecialty of pediatric medicine. Different pathologic and physiologic processes occur in pediatric patients who require intensive care. Thus, the faculty and staffing requirement differ in many aspects from those of adult intensive care units (ICUs). In Taiwan, pediatric intensive ...
journal_title:Pediatrics and neonatology
pub_type: 杂志文章,评审
doi:10.1016/S1875-9572(09)60061-9
更新日期:2009-10-01 00:00:00
abstract:BACKGROUND:Congenital vocal cord paralysis (VCP) is a common cause of congenital stridor. Before the widespread application of flexible bronchoscopy (FB) by pediatricians, congenital stridor in infants was usually attributed to laryngomalacia. Prompt recognition and careful follow-up is crucial for the management of co...
journal_title:Pediatrics and neonatology
pub_type: 杂志文章
doi:10.1016/S1875-9572(09)60006-1
更新日期:2008-10-01 00:00:00
abstract:BACKGROUND:The parameters of oxidative stress [advanced oxidation protein products (AOPPs), malondialdehyde (MDA), and S100B] and the effect of intensive phototherapy (PT) on these parameters have not been studied extensively in newborns with significant hyperbilirubinemia (SH). We aimed to measure the levels of MDA, S...
journal_title:Pediatrics and neonatology
pub_type: 杂志文章
doi:10.1016/j.pedneo.2014.06.006
更新日期:2015-04-01 00:00:00
abstract::Cerebro-costo-mandibular syndrome (CCMS) consists of severe micrognathia, glossoptosis, posterior rib-gap defects and developmental delay. It may cause upper airway obstruction andflail chest, resulting in neonatal hypoxia, and possibly death. Early airway management or surgical intervention to maintain a patent airwa...
journal_title:Pediatrics and neonatology
pub_type: 杂志文章
doi:10.1016/S1875-9572(10)60011-3
更新日期:2010-02-01 00:00:00
abstract:BACKGROUND:Parents often express concerns about feeding difficulties in their child. We hypothesized that these parental concerns were associated with adverse growth status in early childhood. We aimed to determine the prevalence of such concerns and whether these concerns were associated with adverse growth status in ...
journal_title:Pediatrics and neonatology
pub_type: 杂志文章
doi:10.1016/j.pedneo.2019.04.004
更新日期:2019-12-01 00:00:00
abstract:BACKGROUND:Management of a first attack of acute urticaria in children is dependent on the etiology of the disease. Knowledge of the various etiologies of urticaria will help primary physicians to perform appropriate clinical assessments. In this study, we analyzed the etiologies and their prevalence in first-attack ac...
journal_title:Pediatrics and neonatology
pub_type: 杂志文章
doi:10.1016/S1875-9572(08)60014-5
更新日期:2008-06-01 00:00:00
abstract:BACKGROUND:Neonates with a single umbilical artery (SUA) are considered at increased risk for chromosomal and structural abnormalities, and an increased adverse perinatal outcome. OBJECTIVE:The specific aims of our study were to evaluate (1) the association of asymptomatic infants with isolated SUA and perinatal outco...
journal_title:Pediatrics and neonatology
pub_type: 杂志文章
doi:10.1016/S1875-9572(09)60016-4
更新日期:2008-12-01 00:00:00
abstract:BACKGROUND:Domperidone has been widely used in children with gastroesophageal reflux disease (GERD). Studies on the effects of domperidone on corrected QT interval (QTc) in young children are limited. Our aim was to study the effect of domperidone on the repolarization abnormalities assessed by electrocardiogram (ECG) ...
journal_title:Pediatrics and neonatology
pub_type: 杂志文章
doi:10.1016/j.pedneo.2015.03.015
更新日期:2016-02-01 00:00:00
abstract:BACKGROUND:Pneumothorax is more frequent in the neonatal period, especially among premature infants. Pigtail catheters have been shown to be as effective as and less invasive than traditional chest tubes in adults; however, data regarding premature infants are limited. We aimed to compare the efficacy, safety, and comp...
journal_title:Pediatrics and neonatology
pub_type: 杂志文章
doi:10.1016/j.pedneo.2014.01.002
更新日期:2014-10-01 00:00:00
abstract:BACKGROUND:Hypoglycemia is common in neonates and may cause adverse neurological outcomes. Guidelines should aim to prevent repeated hypoglycemic episodes in risk groups, but they are not usually stratified according to the severity of hypoglycemia risk, which may lead to inappropriate and redundant interventions. We e...
journal_title:Pediatrics and neonatology
pub_type: 杂志文章
doi:10.1016/j.pedneo.2016.12.002
更新日期:2017-10-01 00:00:00
abstract::Hepatic veno-occlusive disease (VOD), also called sinusoidal obstruction syndrome, is rapidly progressing and involves life-threatening complications that can occur in patients receiving chemotherapy and/or bone marrow transplantation. No completely satisfactory treatmentstrategies have yet been established. We presen...
journal_title:Pediatrics and neonatology
pub_type: 杂志文章
doi:10.1016/S1875-9572(08)60029-7
更新日期:2008-08-01 00:00:00
abstract:BACKGROUND:The indications for ductus arteriosus ligation in very-low-birth-weight infants (VLBWIs) with persistent ductus arteriosus (PDA) are unclear. Increased left ventricular end-diastolic dimension (LVDd) is commonly found in patients with PDA. Here, the enlargement of LVDd in term and preterm neonates without co...
journal_title:Pediatrics and neonatology
pub_type: 杂志文章
doi:10.1016/j.pedneo.2013.10.009
更新日期:2014-08-01 00:00:00
abstract:BACKGROUND:Over the years the need for surgical treatment, timing of intervention, and the type of surgical approach have been discussed, but the treatment of congenital lung malformations remains controversial. The aim of this study was to compare the thoracotomy approach with the thoracoscopic technique by evaluating...
journal_title:Pediatrics and neonatology
pub_type: 杂志文章
doi:10.1016/j.pedneo.2015.10.009
更新日期:2016-12-01 00:00:00
abstract::Internal herniation is a rare cause of intestinal obstruction, especially in the emergency department. We report a child with acute abdomen resulting from transmesenteric internal herniation of the small bowel. Radiographic findings revealed gaseous distension of the bowel loops in the upper abdominal area with a pauc...
journal_title:Pediatrics and neonatology
pub_type: 杂志文章
doi:10.1016/j.pedneo.2012.12.008
更新日期:2014-04-01 00:00:00
abstract::The recent introduction of different non-invasive ventilation modes for preterm has decreased the need for intubation, invasive ventilation and sedation. However, specific guidelines for each non-invasive mode are still lacking. This paper reviews available evidence for each of the commonly used noninvasive mode. Elec...
journal_title:Pediatrics and neonatology
pub_type: 杂志文章,评审
doi:10.1016/j.pedneo.2019.09.014
更新日期:2020-04-01 00:00:00
abstract::Nystagmus is an involuntary rhythmic oscillation of the eyes, which leads to reduced visual acuity due to the excessive motion of images on the retina. Nystagmus can be grouped into infantile nystagmus (IN), which usually appears in the first 3-6 months of life, and acquired nystagmus (AN), which appears later. IN can...
journal_title:Pediatrics and neonatology
pub_type: 杂志文章,评审
doi:10.1016/j.pedneo.2014.02.007
更新日期:2014-10-01 00:00:00
abstract::Pneumothorax-associated pneumoretroperitoneum and perirenal air have rarely been reported in infants. We report a case of an extremely low-birth-weight infant who developed pneumoretroperitoneum and perirenal air associated with tension pneumothorax and deteriorated acutely despite prompt pleural water-seal vacuum dra...
journal_title:Pediatrics and neonatology
pub_type: 杂志文章
doi:10.1016/j.pedneo.2010.12.004
更新日期:2011-02-01 00:00:00