Seizure Recurrence in Children after Stopping Antiepileptic Medication: 5-Year Follow-Up.

Abstract:

BACKGROUND:We wanted to identify in children with epilepsy the factors associated with seizure control and recurrence after a 2-year remission. METHODS:We did a 5-year follow-up of epileptic children whose antiepileptic medication had been stopped. Bivariate and multivariate analyses were used to compare features of electroencephalograms (EEGs) and clinical findings. In this study, 43 patients with and 64 without a seizure recurrence (SR) were enrolled. RESULTS:Clinical features strongly associated with SR in the univariate analysis included a symptomatic etiology for seizures, a history of status epilepticus, treatment duration before stopping antiepileptic drugs, and abnormal EEG findings at the time of stopping antiepileptic drugs. CONCLUSION:We found that a history of status epilepticus, symptomatic partial epilepsy, treatment duration before stopping antiepileptic drugs, and an abnormal EEG when the medication was stopped are important predictors of SR. The risk factors of SR after discontinuing antiepileptic drugs have been investigated in several studies. However, a history of status epilepticus as a predictive factor is rarely mentioned.

journal_name

Pediatr Neonatol

authors

Lee IC,Li SY,Chen YJ

doi

10.1016/j.pedneo.2016.08.005

subject

Has Abstract

pub_date

2017-08-01 00:00:00

pages

338-343

issue

4

eissn

1875-9572

issn

2212-1692

pii

S1875-9572(16)30371-0

journal_volume

58

pub_type

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