Treatment with high-dose methylprednisolone for hepatic veno-occlusive disease in a child with rhabdomyosarcoma.

Abstract:

:Hepatic veno-occlusive disease (VOD), also called sinusoidal obstruction syndrome, is rapidly progressing and involves life-threatening complications that can occur in patients receiving chemotherapy and/or bone marrow transplantation. No completely satisfactory treatmentstrategies have yet been established. We present a case of rhabdomyosarcoma ina 21-month-old boy who developed pancytopenia, dyspnea, jaundice, massive ascites and body weight gain of more than 10% after receiving conventional chemotherapy. Hepatic VOD was diagnosed. He recovered after supportive care and treatment with high-dose methylprednisolone.

journal_name

Pediatr Neonatol

authors

Chen IL,Yang SN,Hsiao CC,Wu KS,Sheen JM

doi

10.1016/S1875-9572(08)60029-7

subject

Has Abstract

pub_date

2008-08-01 00:00:00

pages

141-4

issue

4

eissn

1875-9572

issn

2212-1692

pii

S1875-9572(08)60029-7

journal_volume

49

pub_type

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